IL214913A - Reversed stabilized transcriptase fusion proteins - Google Patents
Reversed stabilized transcriptase fusion proteinsInfo
- Publication number
- IL214913A IL214913A IL214913A IL21491311A IL214913A IL 214913 A IL214913 A IL 214913A IL 214913 A IL214913 A IL 214913A IL 21491311 A IL21491311 A IL 21491311A IL 214913 A IL214913 A IL 214913A
- Authority
- IL
- Israel
- Prior art keywords
- fusion proteins
- reverse transcriptase
- transcriptase fusion
- stabilized reverse
- stabilized
- Prior art date
Links
- 102100034343 Integrase Human genes 0.000 title 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15733209P | 2009-03-04 | 2009-03-04 | |
| PCT/US2010/026165 WO2010102085A2 (en) | 2009-03-04 | 2010-03-04 | Stabilized reverse transcriptase fusion proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL214913A0 IL214913A0 (en) | 2011-11-30 |
| IL214913A true IL214913A (en) | 2017-06-29 |
Family
ID=42710216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL214913A IL214913A (en) | 2009-03-04 | 2011-09-01 | Reversed stabilized transcriptase fusion proteins |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10113156B2 (https=) |
| EP (2) | EP2403941B1 (https=) |
| JP (2) | JP5882064B2 (https=) |
| CN (1) | CN102421791A (https=) |
| AU (1) | AU2010221284B2 (https=) |
| BR (1) | BRPI1009221A2 (https=) |
| CA (1) | CA2754476A1 (https=) |
| IL (1) | IL214913A (https=) |
| MX (1) | MX2011009205A (https=) |
| WO (1) | WO2010102085A2 (https=) |
| ZA (1) | ZA201107207B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101818126B1 (ko) * | 2011-02-09 | 2018-01-15 | (주)바이오니아 | 열안정성이 증가된 역전사효소 |
| AU2012220596B2 (en) * | 2011-02-23 | 2016-05-12 | Board Of Regents | Use of template switching for DNA synthesis |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN108368151B (zh) | 2015-12-07 | 2022-11-15 | 生物辐射实验室股份有限公司 | 二聚逆转录酶 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
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| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019070843A1 (en) * | 2017-10-03 | 2019-04-11 | Board Of Regents, The University Of Texas System | INVERSE TRANSCRIPTASE WITH LTR-FREE BACKLIGHTS AND USES THEREOF |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021165273A1 (en) * | 2020-02-17 | 2021-08-26 | Leadxpro Ag | Pro-macrobodies for the enhancement of structure research |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| CA3193099A1 (en) | 2020-09-24 | 2022-03-31 | David R. Liu | Prime editing guide rnas, compositions thereof, and methods of using the same |
| EP4274894A2 (en) | 2021-01-11 | 2023-11-15 | The Broad Institute, Inc. | Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision |
| JP2024530487A (ja) | 2021-08-06 | 2024-08-21 | ザ ブロード インスティテュート，インコーポレーテッド | 改善されたプライムエディターおよび使用方法 |
| EP4137582B1 (en) * | 2021-08-17 | 2026-01-28 | New England Biolabs, Inc. | Rolling circle reverse transcription of circular rna |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| WO2023076898A1 (en) | 2021-10-25 | 2023-05-04 | The Broad Institute, Inc. | Methods and compositions for editing a genome with prime editing and a recombinase |
| WO2023102538A1 (en) | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Self-assembling virus-like particles for delivery of prime editors and methods of making and using same |
| WO2023205687A1 (en) | 2022-04-20 | 2023-10-26 | The Broad Institute, Inc. | Improved prime editing methods and compositions |
| WO2023240137A1 (en) | 2022-06-08 | 2023-12-14 | The Board Institute, Inc. | Evolved cas14a1 variants, compositions, and methods of making and using same in genome editing |
| WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| EP4619515A1 (en) | 2022-11-17 | 2025-09-24 | The Broad Institute, Inc. | Prime editor delivery by aav |
| WO2024168147A2 (en) | 2023-02-09 | 2024-08-15 | The Broad Institute, Inc. | Evolved recombinases for editing a genome in combination with prime editing |
| WO2024206125A1 (en) | 2023-03-24 | 2024-10-03 | The Broad Institute, Inc. | Use of prime editing for treating sickle cell disease |
| AU2024357861A1 (en) | 2023-10-12 | 2026-04-23 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5643758A (en) | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| US5654176A (en) | 1987-05-28 | 1997-08-05 | Amrad Corporation Limited | Fusion proteins containing glutathione-s-transferase |
| US5736373A (en) * | 1996-09-23 | 1998-04-07 | Becton, Dickinson And Company | Thermostable DNA polymerase from Bacillus pallidus |
| US7001745B1 (en) | 1998-09-30 | 2006-02-21 | New England Biolabs, Inc. | Intein mediated peptide ligation |
| US6436677B1 (en) | 2000-03-02 | 2002-08-20 | Promega Corporation | Method of reverse transcription |
| US6627424B1 (en) * | 2000-05-26 | 2003-09-30 | Mj Bioworks, Inc. | Nucleic acid modifying enzymes |
| US7507412B2 (en) | 2001-07-18 | 2009-03-24 | Merck Patent Gmbh | Glycoprotein VI fusion proteins |
| US7670807B2 (en) * | 2004-03-10 | 2010-03-02 | East Tennessee State Univ. Research Foundation | RNA-dependent DNA polymerase from Geobacillus stearothermophilus |
| US7935509B2 (en) | 2004-08-13 | 2011-05-03 | New England Biolabs, Inc. | Intracellular production of a nuclease |
-
2010
- 2010-03-04 US US13/254,223 patent/US10113156B2/en active Active
- 2010-03-04 MX MX2011009205A patent/MX2011009205A/es not_active Application Discontinuation
- 2010-03-04 CA CA2754476A patent/CA2754476A1/en not_active Abandoned
- 2010-03-04 EP EP10749312.4A patent/EP2403941B1/en active Active
- 2010-03-04 CN CN2010800201231A patent/CN102421791A/zh active Pending
- 2010-03-04 EP EP18184036.4A patent/EP3415621A1/en not_active Withdrawn
- 2010-03-04 AU AU2010221284A patent/AU2010221284B2/en not_active Ceased
- 2010-03-04 BR BRPI1009221A patent/BRPI1009221A2/pt not_active IP Right Cessation
- 2010-03-04 WO PCT/US2010/026165 patent/WO2010102085A2/en not_active Ceased
- 2010-03-04 JP JP2011553101A patent/JP5882064B2/ja active Active
-
2011
- 2011-09-01 IL IL214913A patent/IL214913A/en active IP Right Grant
- 2011-10-03 ZA ZA2011/07207A patent/ZA201107207B/en unknown
-
2015
- 2015-08-03 JP JP2015153175A patent/JP2015193666A/ja not_active Withdrawn
-
2016
- 2016-05-25 US US15/164,208 patent/US10150955B2/en active Active
-
2018
- 2018-08-01 US US16/051,549 patent/US10858636B2/en active Active
- 2018-08-01 US US16/051,544 patent/US20180340158A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010221284A1 (en) | 2011-10-27 |
| WO2010102085A4 (en) | 2011-01-06 |
| AU2010221284B2 (en) | 2015-10-01 |
| US20180340158A1 (en) | 2018-11-29 |
| WO2010102085A2 (en) | 2010-09-10 |
| BRPI1009221A2 (pt) | 2016-03-15 |
| EP2403941A2 (en) | 2012-01-11 |
| EP2403941B1 (en) | 2018-10-03 |
| JP2015193666A (ja) | 2015-11-05 |
| US20180346890A1 (en) | 2018-12-06 |
| IL214913A0 (en) | 2011-11-30 |
| US10858636B2 (en) | 2020-12-08 |
| JP2012519489A (ja) | 2012-08-30 |
| US20120009630A1 (en) | 2012-01-12 |
| ZA201107207B (en) | 2012-12-27 |
| JP5882064B2 (ja) | 2016-03-09 |
| US10113156B2 (en) | 2018-10-30 |
| CN102421791A (zh) | 2012-04-18 |
| US10150955B2 (en) | 2018-12-11 |
| WO2010102085A3 (en) | 2010-11-18 |
| EP2403941A4 (en) | 2012-09-05 |
| MX2011009205A (es) | 2011-09-30 |
| CA2754476A1 (en) | 2010-09-10 |
| EP3415621A1 (en) | 2018-12-19 |
| US20160289652A1 (en) | 2016-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |