IL207167A - Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof - Google Patents
Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereofInfo
- Publication number
- IL207167A IL207167A IL207167A IL20716710A IL207167A IL 207167 A IL207167 A IL 207167A IL 207167 A IL207167 A IL 207167A IL 20716710 A IL20716710 A IL 20716710A IL 207167 A IL207167 A IL 207167A
- Authority
- IL
- Israel
- Prior art keywords
- alphavirus
- attenuated
- veev
- ires
- virus
- Prior art date
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Classifications
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- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36161—Methods of inactivation or attenuation
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36171—Demonstrated in vivo effect
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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| US6222908P | 2008-01-24 | 2008-01-24 | |
| PCT/US2009/000458 WO2009131604A2 (en) | 2008-01-24 | 2009-01-23 | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
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| IL207167A0 IL207167A0 (en) | 2010-12-30 |
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| IL232032A IL232032A0 (en) | 2008-01-24 | 2014-04-09 | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
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| PL2183368T3 (pl) * | 2007-06-21 | 2016-12-30 | Kasety bez promotora do ekspresji alfawirusowych białek strukturalnych | |
| WO2009131604A2 (en) | 2008-01-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
| US8961995B2 (en) | 2012-09-20 | 2015-02-24 | Uab Research Foundation | Methods and compositions for alphavirus replicons |
| BR112015006840A2 (pt) | 2012-09-27 | 2017-11-21 | Res Found Dev | vírus chikungunya atenuado |
| MX361342B (es) | 2013-03-14 | 2018-12-04 | Takeda Vaccines Inc | Composiciones y metodos para formulaciones de alfavirus vivos atenuados. |
| MX2018011839A (es) * | 2016-03-31 | 2019-05-23 | Takeda Vaccines Inc | Constructos de alfavirus vivo atenuado y metodos y usos de los mismos. |
| PH12018502460B1 (en) * | 2016-05-27 | 2023-11-08 | Univ Griffith | Arthrogenic alphavirus vaccine |
| MX2019013259A (es) | 2017-05-08 | 2020-01-13 | Gritstone Oncology Inc | Vectores de neoantigeno de alfavirus. |
| WO2020028749A1 (en) * | 2018-08-03 | 2020-02-06 | Uab Research Foundation | Methods and compositions for alphavirus vaccine |
| CN109536464B (zh) * | 2018-12-10 | 2022-06-10 | 中国科学院武汉病毒研究所 | 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用 |
| AU2020282369A1 (en) | 2019-05-30 | 2022-01-20 | Seattle Project Corp. | Modified adenoviruses |
| AU2020417800A1 (en) | 2019-12-31 | 2022-07-14 | Elixirgen Therapeutics, Inc. | Temperature-based transient delivery of nucleic acids and proteins to cells and tissues |
| CA3187258A1 (en) | 2020-08-06 | 2022-02-10 | Karin Jooss | Multiepitope vaccine cassettes |
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| US6451592B1 (en) * | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| CA2327189A1 (en) * | 2000-12-21 | 2002-06-21 | The Minister Of National Defence | Novel dna-based vaccine against the encephalitis alphaviruses |
| JP5016305B2 (ja) * | 2003-03-20 | 2012-09-05 | アルファヴァックス，インコーポレイテッド | 改良されたアルファウイルスレプリコンおよびヘルパー構築物 |
| US7603447B2 (en) | 2004-07-30 | 2009-10-13 | Research In Motion Limited | Method and system for coordinating device setting between a communications client and its host device |
| US7332322B2 (en) * | 2004-09-14 | 2008-02-19 | Ilya Frolov | Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof |
| CA2579507C (en) | 2006-03-15 | 2017-06-13 | Institut Pasteur | Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof |
| WO2009131604A2 (en) * | 2008-01-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
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