IL202049A - שיטה לייצור חלבון רקומביננטי בסקלת ייצור - Google Patents
שיטה לייצור חלבון רקומביננטי בסקלת ייצורInfo
- Publication number
- IL202049A IL202049A IL202049A IL20204909A IL202049A IL 202049 A IL202049 A IL 202049A IL 202049 A IL202049 A IL 202049A IL 20204909 A IL20204909 A IL 20204909A IL 202049 A IL202049 A IL 202049A
- Authority
- IL
- Israel
- Prior art keywords
- producing
- recombinant protein
- manufacturing scale
- scale
- manufacturing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07009872 | 2007-05-17 | ||
| PCT/EP2008/056062 WO2008142028A1 (en) | 2007-05-17 | 2008-05-16 | Method for producing a recombinant protein on a manufacturing scale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL202049A0 IL202049A0 (en) | 2011-08-01 |
| IL202049A true IL202049A (he) | 2017-02-28 |
Family
ID=38481202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202049A IL202049A (he) | 2007-05-17 | 2009-11-11 | שיטה לייצור חלבון רקומביננטי בסקלת ייצור |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9683252B2 (he) |
| EP (2) | EP3399042B9 (he) |
| JP (2) | JP5837747B2 (he) |
| KR (1) | KR101504485B1 (he) |
| AU (1) | AU2008252990B2 (he) |
| CA (1) | CA2687170C (he) |
| IL (1) | IL202049A (he) |
| WO (1) | WO2008142028A1 (he) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008252990B2 (en) * | 2007-05-17 | 2015-01-15 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Method for producing a recombinant protein on a manufacturing scale |
| US20110236927A1 (en) * | 2008-08-27 | 2011-09-29 | Massachusetts Institute Of Technology | Genetically stabilized tandem gene duplication |
| JP5513759B2 (ja) * | 2009-03-13 | 2014-06-04 | 花王株式会社 | タンパク質又はポリペプチドの生産方法 |
| CU24158B1 (es) * | 2012-09-18 | 2016-03-30 | Ct De Ingeniería Genética Y Biotecnología | Método de obtención de 1-kestosa |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| JPWO2015178466A1 (ja) * | 2014-05-21 | 2017-04-20 | 味の素株式会社 | フィブロイン様タンパク質の製造法 |
| DE102014212675A1 (de) * | 2014-07-01 | 2016-01-07 | Wacker Chemie Ag | T7-Expressionssystem, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von rekombinanten Proteinen |
| CN104313002B (zh) * | 2014-10-14 | 2017-03-08 | 江南大学 | 一种高密度培养重组大肠杆菌产脯氨酸氨肽酶的方法 |
| CN109563531A (zh) * | 2016-08-02 | 2019-04-02 | 丝芭博株式会社 | 重组蛋白的生产方法 |
| GB201704659D0 (en) | 2017-03-24 | 2017-05-10 | Fujifilm Diosynth Biotechnologies Uk Ltd | Expression system |
| WO2020053285A1 (en) | 2018-09-11 | 2020-03-19 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Inducible expression system for plasmid-free production of a protein of interest |
| CU24557B1 (es) * | 2018-09-27 | 2021-12-08 | Ct Ingenieria Genetica Biotecnologia | Composición sólida de uso agrícola que comprende cepa bacteriana de brevibacterium celere |
| CN113260626B (zh) | 2018-11-05 | 2024-09-13 | 豪夫迈·罗氏有限公司 | 在原核宿主细胞中产生双链蛋白质的方法 |
| JP7762935B2 (ja) * | 2019-01-31 | 2025-10-31 | Ｓｐｉｂｅｒ株式会社 | 組換え細胞、発現構築物、及び組換えタンパク質の製造方法 |
| WO2021123402A1 (en) | 2019-12-20 | 2021-06-24 | Engenes Biotech Gmbh | Continuous bioproduction by decoupling growth and production |
| JP2023538225A (ja) * | 2020-07-24 | 2023-09-07 | デューク ユニバーシティ | アセチル－ＣｏＡ誘導産物を産生するための方法及び組成物 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US4963495A (en) | 1984-10-05 | 1990-10-16 | Genentech, Inc. | Secretion of heterologous proteins |
| US4680262A (en) | 1984-10-05 | 1987-07-14 | Genentech, Inc. | Periplasmic protein recovery |
| US5861273A (en) | 1993-12-21 | 1999-01-19 | Celtrix Phamraceuticals, Inc. | Chromosomal expression of heterologous genes in bacterial cells |
| JP3784111B2 (ja) | 1996-07-31 | 2006-06-07 | ロシュ ダイアグノスティックス コーポレーション | 抗原濃度測定方法 |
| DE69815384T2 (de) * | 1997-12-05 | 2003-12-04 | Europaeisches Laboratorium Fuer Molekularbiologie (Embl) | Neue methode zur klonierung dns unter anwendung des e. coli rece/rect rekombinationssystems |
| US6355412B1 (en) | 1999-07-09 | 2002-03-12 | The European Molecular Biology Laboratory | Methods and compositions for directed cloning and subcloning using homologous recombination |
| AU6511000A (en) * | 1999-08-02 | 2001-02-19 | Baylor College Of Medicine | Novel vectors and system for selectable targeted integration of transgenes into a chromosome without antibiotic resistance markers |
| WO2001018222A1 (en) | 1999-09-07 | 2001-03-15 | University Of Florida | Methods and compositions for the chromosomal integration of heterologous sequences |
| US20040235173A1 (en) * | 2000-07-03 | 2004-11-25 | Gala Design, Inc. | Production of host cells containing multiple integrating vectors by serial transduction |
| AU8337701A (en) | 2000-08-14 | 2002-02-25 | Us Health | Enhanced homologous recombination mediated by lambda recombination proteins |
| WO2002040679A2 (en) * | 2000-11-15 | 2002-05-23 | Archer-Daniels-Midland Company | Corynebacterium glutamicum promoters |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| BR0214542A (pt) | 2001-12-12 | 2005-08-16 | Lilly Co Eli | Célula hospedeira, sistema de expressão, e, processos de preparação de uma célula hospedeira, e de uma proteìna alvo |
| WO2003066801A2 (en) | 2002-02-05 | 2003-08-14 | Indian Institute Of Technology | Method for specific integration of t7 rna polymerase gene in the chromosome of corynebacterial and the resultant corynebacteria-t7 promoter based shuttle vector system. |
| WO2003089605A2 (en) * | 2002-04-22 | 2003-10-30 | Genencor International, Inc. | Method of creating a library of bacterial clones with varying levels of gene expression |
| US20040209370A1 (en) | 2002-12-19 | 2004-10-21 | Wonchul Suh | Method for chromosomal engineering |
| EP1604023A2 (en) | 2003-03-12 | 2005-12-14 | Ajinomoto Co., Inc. | Optimization of bacterial sucab expression by promoter mutagenesis for efficient l-glutamic acid production |
| EP1584687A1 (en) | 2004-04-08 | 2005-10-12 | Boehringer Ingelheim Austria GmbH | Method for producing plasmid DNA on a manufacturing scale by fermentation of the Escherichia Coli K-12 strain JM108 |
| EP1584680A1 (en) | 2004-04-08 | 2005-10-12 | Boehringer Ingelheim Austria GmbH | Fed-batch fermentation process for the production of plasmid DNA |
| TWI311152B (en) | 2004-09-17 | 2009-06-21 | Boehringer Ingelheim Rcv Gmbh & Co K | Host-vector system for antibiotic-free cole1 plasmid propagation |
| WO2006042548A1 (en) * | 2004-10-22 | 2006-04-27 | Novozymes A/S | Stable genomic integration of multiple polynucleotide copies |
| US8058410B2 (en) | 2005-04-26 | 2011-11-15 | Sandoz Ag | Affinity ligands |
| US8110672B2 (en) * | 2005-04-27 | 2012-02-07 | Massachusetts Institute Of Technology | Promoter engineering and genetic control |
| AU2008252990B2 (en) | 2007-05-17 | 2015-01-15 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Method for producing a recombinant protein on a manufacturing scale |
-
2008
- 2008-05-16 AU AU2008252990A patent/AU2008252990B2/en active Active
- 2008-05-16 CA CA2687170A patent/CA2687170C/en active Active
- 2008-05-16 KR KR1020097024461A patent/KR101504485B1/ko active Active
- 2008-05-16 WO PCT/EP2008/056062 patent/WO2008142028A1/en not_active Ceased
- 2008-05-16 EP EP18158727.0A patent/EP3399042B9/en active Active
- 2008-05-16 JP JP2010507934A patent/JP5837747B2/ja active Active
- 2008-05-16 US US12/599,843 patent/US9683252B2/en active Active
- 2008-05-16 EP EP08759698.7A patent/EP2160469B1/en active Active
-
2009
- 2009-11-11 IL IL202049A patent/IL202049A/he not_active IP Right Cessation
-
2015
- 2015-07-16 JP JP2015142263A patent/JP5996052B2/ja active Active
-
2017
- 2017-05-12 US US15/594,249 patent/US10752930B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2160469A1 (en) | 2010-03-10 |
| US9683252B2 (en) | 2017-06-20 |
| US20170253900A1 (en) | 2017-09-07 |
| KR20100017315A (ko) | 2010-02-16 |
| EP2160469B1 (en) | 2018-02-28 |
| EP3399042B9 (en) | 2025-03-26 |
| EP3399042A1 (en) | 2018-11-07 |
| AU2008252990B2 (en) | 2015-01-15 |
| US10752930B2 (en) | 2020-08-25 |
| KR101504485B1 (ko) | 2015-03-24 |
| IL202049A0 (en) | 2011-08-01 |
| WO2008142028A1 (en) | 2008-11-27 |
| JP2010527239A (ja) | 2010-08-12 |
| JP5837747B2 (ja) | 2015-12-24 |
| JP5996052B2 (ja) | 2016-09-21 |
| JP2015221045A (ja) | 2015-12-10 |
| AU2008252990A1 (en) | 2008-11-27 |
| CA2687170A1 (en) | 2008-11-27 |
| CA2687170C (en) | 2019-06-25 |
| US20110045531A1 (en) | 2011-02-24 |
| EP3399042B1 (en) | 2024-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |