IL195816A0 - Hif hydroxylase inhibitors for treatment of anemia of cancer - Google Patents

Hif hydroxylase inhibitors for treatment of anemia of cancer

Info

Publication number
IL195816A0
IL195816A0 IL195816A IL19581608A IL195816A0 IL 195816 A0 IL195816 A0 IL 195816A0 IL 195816 A IL195816 A IL 195816A IL 19581608 A IL19581608 A IL 19581608A IL 195816 A0 IL195816 A0 IL 195816A0
Authority
IL
Israel
Prior art keywords
anemia
cancer
treatment
hydroxylase inhibitors
hif hydroxylase
Prior art date
Application number
IL195816A
Other languages
English (en)
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of IL195816A0 publication Critical patent/IL195816A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL195816A 2006-06-15 2008-12-09 Hif hydroxylase inhibitors for treatment of anemia of cancer IL195816A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/455,202 US20070293575A1 (en) 2006-06-15 2006-06-15 Compounds and methods for treatment of cancer-related anemia
PCT/US2007/014157 WO2007146438A1 (en) 2006-06-15 2007-06-14 Hif hydroxylase inhibitors for treatment of anemia of cancer

Publications (1)

Publication Number Publication Date
IL195816A0 true IL195816A0 (en) 2009-09-01

Family

ID=38571332

Family Applications (1)

Application Number Title Priority Date Filing Date
IL195816A IL195816A0 (en) 2006-06-15 2008-12-09 Hif hydroxylase inhibitors for treatment of anemia of cancer

Country Status (7)

Country Link
US (2) US20070293575A1 (https=)
EP (1) EP2035000A1 (https=)
JP (1) JP2009540004A (https=)
CN (1) CN101500569A (https=)
AU (1) AU2007258213A1 (https=)
IL (1) IL195816A0 (https=)
WO (1) WO2007146438A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108681A1 (en) 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
BRPI0707302B8 (pt) * 2006-01-27 2021-05-25 Fibrogen Inc compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende
BRPI0710527B8 (pt) * 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
TW200845991A (en) 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: hydroxylase inhibitors
WO2009073669A1 (en) * 2007-12-03 2009-06-11 Fibrogen, Inc. Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions
EP2252619B1 (en) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
WO2009100250A1 (en) 2008-02-05 2009-08-13 Fibrogen, Inc. Chromene derivatives and use thereof as hif hydroxylase activity inhibitors
US8217043B2 (en) * 2008-08-20 2012-07-10 Fibrogen, Inc. Compounds and methods for their use
JP5649584B2 (ja) 2008-11-14 2015-01-07 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体
WO2010059549A1 (en) * 2008-11-18 2010-05-27 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
WO2011048611A1 (en) 2009-10-07 2011-04-28 Torrent Pharmaceuticals Limited Novel fused pyridazine derivatives
TWI500623B (zh) 2009-10-13 2015-09-21 Torrent Pharmaceuticals Ltd 新穎稠合噻唑及噁唑嘧啶酮
US8541430B2 (en) 2009-11-27 2013-09-24 Torrent Pharmaceuticals Limited Fused thiazolo and oxazolo pyrimidinones
EP2649182A4 (en) * 2010-12-10 2015-05-06 Alnylam Pharmaceuticals Inc Compositions and methods for increasing erythropoietin (epo) production
US20140057941A1 (en) * 2011-01-13 2014-02-27 Kin-Hung (Peony) Yu Methods For Increasing Mean Corpuscular Volume
US20140171465A1 (en) * 2011-01-13 2014-06-19 Fibrogen, Inc. Methods For Increasing Reticulocyte Hemoglobin Content
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
CN104024227B8 (zh) * 2011-07-22 2025-07-29 北京贝美拓新药研发有限公司 抑制脯氨酸羟化酶活性的化合物的晶型及其应用
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
WO2013134660A1 (en) 2012-03-09 2013-09-12 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors
AU2013290438C1 (en) 2012-07-16 2019-01-03 Kyntra Bio, Inc. Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
EP3219706A1 (en) 2012-07-16 2017-09-20 Fibrogen, Inc. Process for making isoquinoline compounds
AU2014209319B2 (en) 2013-01-24 2018-04-19 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
HRP20200615T1 (hr) 2013-06-06 2020-07-10 Fibrogen, Inc. Farmaceutske formulacije inhibitora hif hidroksilaze
MY180626A (en) 2013-11-15 2020-12-03 Akebia Therapeutics Inc Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2298301T3 (en) * 2001-12-06 2018-10-01 Fibrogen Inc MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
WO2005007183A2 (en) * 2003-07-17 2005-01-27 Thromb-X Nv Treatment of anemia
AU2006254897A1 (en) * 2005-06-06 2006-12-14 Fibrogen, Inc. Improved treatment for anemia using a HIF-alpha stabilising agent
MX2007016160A (es) * 2005-06-15 2008-03-07 Fibrogen Inc Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer.

Also Published As

Publication number Publication date
JP2009540004A (ja) 2009-11-19
US20110015223A1 (en) 2011-01-20
CN101500569A (zh) 2009-08-05
WO2007146438A1 (en) 2007-12-21
EP2035000A1 (en) 2009-03-18
US20070293575A1 (en) 2007-12-20
AU2007258213A1 (en) 2007-12-21

Similar Documents

Publication Publication Date Title
IL195816A0 (en) Hif hydroxylase inhibitors for treatment of anemia of cancer
IL229878A0 (en) Compounds for the treatment of cancer
IL248204A0 (en) Combined treatment of tumors expressing 38cd
IL199907A0 (en) Composition for treatment of pancreatic cancer
IL197315A0 (en) Treatment of cancer
IL212762A0 (en) Thiochromene derivatives as hif hydroxylase inhibitors
EP2318406A4 (en) THIOSEMICARBAZONHERMAL COMPOUNDS AND CANCER TREATMENT PROCEDURES
ZA201000085B (en) 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors
EP1945224A4 (en) REDUCING SIDE EFFECTS OF AROMATASE INHIBITORS USED IN THE TREATMENT OF BREAST CANCER
EP2049139A4 (en) TREATMENT OF TUMORS EXPRESSING RAS
IL243294A0 (en) Compounds and compositions for the treatment of cancer
ZA201001720B (en) Mixed metal compounds for treatment of hyperphos phatarmia
IL199689A0 (en) Compounds and method for treatment of cancer
EP2225226A4 (en) COMPOUNDS AND METHOD FOR THE TREATMENT OF CANCER
ZA201101216B (en) Organoarsenic compounds and methods for the treatment of cancer
IL226363A0 (en) Compounds and methods for treating cancer
IL196727A0 (en) Composition and method for treatment of tumors
IL205339A0 (en) Compounds and methods for the treatment of cancer
GB0600903D0 (en) Treatment of cancer
HK1126978A (en) Methods of treating ovarian cancer
IL196361A0 (en) Combination methods of treating cancer
HK1126977A (en) Discontinuous methods of treating cancer
GB0622581D0 (en) Treatment of cancer
GB0604114D0 (en) Combinations for the treatment of cancer
AU2006905260A0 (en) Combination therapy for treatment of cancer