IL191139A0 - Novel pyridopyrazines and their use as modulators of kinases - Google Patents

Novel pyridopyrazines and their use as modulators of kinases

Info

Publication number
IL191139A0
IL191139A0 IL191139A IL19113908A IL191139A0 IL 191139 A0 IL191139 A0 IL 191139A0 IL 191139 A IL191139 A IL 191139A IL 19113908 A IL19113908 A IL 19113908A IL 191139 A0 IL191139 A0 IL 191139A0
Authority
IL
Israel
Prior art keywords
kinases
modulators
pyridopyrazines
novel
novel pyridopyrazines
Prior art date
Application number
IL191139A
Other languages
English (en)
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05024693A external-priority patent/EP1785423A1/de
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of IL191139A0 publication Critical patent/IL191139A0/en

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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IL191139A 2005-11-11 2008-04-29 Novel pyridopyrazines and their use as modulators of kinases IL191139A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73569805P 2005-11-11 2005-11-11
EP05024693A EP1785423A1 (de) 2005-11-11 2005-11-11 Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen
US84976106P 2006-10-06 2006-10-06
PCT/EP2006/068322 WO2007054556A1 (de) 2005-11-11 2006-11-10 Neue pyridopyrazine und deren verwendung als modulatoren von kinasen

Publications (1)

Publication Number Publication Date
IL191139A0 true IL191139A0 (en) 2008-12-29

Family

ID=37654792

Family Applications (1)

Application Number Title Priority Date Filing Date
IL191139A IL191139A0 (en) 2005-11-11 2008-04-29 Novel pyridopyrazines and their use as modulators of kinases

Country Status (10)

Country Link
EP (1) EP1957487A1 (ja)
JP (1) JP5527972B2 (ja)
KR (1) KR101400905B1 (ja)
AR (1) AR060010A1 (ja)
AU (1) AU2006313701B2 (ja)
CA (1) CA2628039A1 (ja)
HK (1) HK1126474A1 (ja)
IL (1) IL191139A0 (ja)
NO (1) NO20082511L (ja)
WO (1) WO2007054556A1 (ja)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
EP1790342A1 (de) * 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1990342A1 (en) * 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
EP2170338A2 (en) * 2007-07-06 2010-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna-pkcs modulates energy regulation and brain function
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
RU2715893C2 (ru) 2014-03-26 2020-03-04 Астекс Терапьютикс Лтд Комбинации ингибитора fgfr и ингибитора igf1r
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
PL3122358T3 (pl) 2014-03-26 2021-06-14 Astex Therapeutics Ltd. Połączenia inhibitorów fgfr i cmet w leczeniu nowotworu
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
BR112018005637B1 (pt) 2015-09-23 2023-11-28 Janssen Pharmaceutica Nv Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos
HUE057090T2 (hu) 2015-09-23 2022-04-28 Janssen Pharmaceutica Nv BI-heteroaril-szubsztituált 1,4-benzodiazepinek és alkalmazásuk rák kezelésében

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Also Published As

Publication number Publication date
JP2009515853A (ja) 2009-04-16
KR101400905B1 (ko) 2014-05-29
AU2006313701B2 (en) 2012-05-31
NO20082511L (no) 2008-06-24
JP5527972B2 (ja) 2014-06-25
CA2628039A1 (en) 2007-05-18
AU2006313701A1 (en) 2007-05-18
WO2007054556A1 (de) 2007-05-18
AR060010A1 (es) 2008-05-21
KR20080068117A (ko) 2008-07-22
HK1126474A1 (en) 2009-09-04
EP1957487A1 (de) 2008-08-20

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