IL185129A0 - Process for making montelukast and intermediates therefor - Google Patents
Process for making montelukast and intermediates thereforInfo
- Publication number
- IL185129A0 IL185129A0 IL185129A IL18512907A IL185129A0 IL 185129 A0 IL185129 A0 IL 185129A0 IL 185129 A IL185129 A IL 185129A IL 18512907 A IL18512907 A IL 18512907A IL 185129 A0 IL185129 A0 IL 185129A0
- Authority
- IL
- Israel
- Prior art keywords
- intermediates therefor
- making montelukast
- montelukast
- making
- intermediates
- Prior art date
Links
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 229960005127 montelukast Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/75—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73775205P | 2005-11-18 | 2005-11-18 | |
| US79442906P | 2006-04-24 | 2006-04-24 | |
| US82438206P | 2006-09-01 | 2006-09-01 | |
| PCT/EP2006/011127 WO2007057225A2 (en) | 2005-11-18 | 2006-11-20 | Process for making montelukast and intermediates therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL185129A0 true IL185129A0 (en) | 2007-12-03 |
Family
ID=37685804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL185129A IL185129A0 (en) | 2005-11-18 | 2007-08-08 | Process for making montelukast and intermediates therefor |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US7601741B2 (de) |
| EP (3) | EP1954679B1 (de) |
| JP (1) | JP2009515922A (de) |
| AR (3) | AR057908A1 (de) |
| AT (1) | ATE497493T1 (de) |
| AU (3) | AU2006314728A1 (de) |
| CA (3) | CA2598093A1 (de) |
| DE (1) | DE602006019979D1 (de) |
| IL (1) | IL185129A0 (de) |
| NO (1) | NO20074188L (de) |
| PT (1) | PT1954679E (de) |
| WO (3) | WO2007057225A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080146809A1 (en) * | 2004-11-19 | 2008-06-19 | Matrix Laboratories Ltd | Process for the Preparation of Novel Amorphous Montelukast Sodium |
| CN101213177A (zh) | 2005-07-05 | 2008-07-02 | 特瓦制药工业有限公司 | 孟鲁司特的纯化 |
| AR057908A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast e intermediarios del mismo |
| EP2014650A1 (de) * | 2007-07-13 | 2009-01-14 | Lonza Ag | Verfahren und Zwischenprodukt zur Herstellung eines Zwischenprodukts bei der Herstellung von Montelukast |
| ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
| WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
| WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| TWI450275B (zh) * | 2010-05-19 | 2014-08-21 | Wistron Corp | 可提升寫入保護之記憶體系統及相關方法 |
| US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
| EP2502910A1 (de) | 2011-03-15 | 2012-09-26 | Laboratorios Lesvi, S.L. | Camphersulfonsalz eines Montelukastschlüssels Zwischenprodukt |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
| CA2038178A1 (en) | 1990-04-05 | 1991-10-06 | Carl C. Greco | Niobium alkoxyalkoxides and process for formation |
| US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5266568A (en) | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
| CA2053209C (en) | 1990-10-12 | 1998-12-08 | Michel L. Belley | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5565473A (en) * | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5428033A (en) * | 1990-10-12 | 1995-06-27 | Merck Frosst Canada, Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
| IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
| US5270324A (en) | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
| TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| US5523477A (en) * | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
| US5869673A (en) | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
| CN1420113A (zh) | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
| CN1171873C (zh) * | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| AU2004283832B2 (en) * | 2003-10-10 | 2011-04-07 | Synthon B.V. | Solid-state montelukast |
| CA2554572A1 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
| US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
| ATE500225T1 (de) * | 2004-07-19 | 2011-03-15 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen davon |
| ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
| AR057908A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast e intermediarios del mismo |
-
2006
- 2006-11-17 AR ARP060105062A patent/AR057908A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105061A patent/AR056815A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105063A patent/AR057909A1/es not_active Application Discontinuation
- 2006-11-20 AU AU2006314728A patent/AU2006314728A1/en not_active Abandoned
- 2006-11-20 US US11/561,724 patent/US7601741B2/en not_active Expired - Fee Related
- 2006-11-20 EP EP06818694A patent/EP1954679B1/de not_active Not-in-force
- 2006-11-20 US US11/561,689 patent/US7476748B2/en not_active Expired - Fee Related
- 2006-11-20 WO PCT/EP2006/011127 patent/WO2007057225A2/en not_active Ceased
- 2006-11-20 CA CA002598093A patent/CA2598093A1/en not_active Abandoned
- 2006-11-20 EP EP06818691A patent/EP1948610A2/de not_active Withdrawn
- 2006-11-20 WO PCT/EP2006/011133 patent/WO2007057227A1/en not_active Ceased
- 2006-11-20 PT PT06818694T patent/PT1954679E/pt unknown
- 2006-11-20 US US11/561,732 patent/US7786138B2/en not_active Expired - Fee Related
- 2006-11-20 DE DE602006019979T patent/DE602006019979D1/de active Active
- 2006-11-20 AU AU2006314729A patent/AU2006314729A1/en not_active Abandoned
- 2006-11-20 EP EP06818693A patent/EP1960362A1/de not_active Withdrawn
- 2006-11-20 CA CA002629840A patent/CA2629840A1/en not_active Abandoned
- 2006-11-20 CA CA002629834A patent/CA2629834A1/en not_active Abandoned
- 2006-11-20 WO PCT/EP2006/011134 patent/WO2007057228A1/en not_active Ceased
- 2006-11-20 AT AT06818694T patent/ATE497493T1/de not_active IP Right Cessation
- 2006-11-20 AU AU2006314726A patent/AU2006314726A1/en not_active Abandoned
- 2006-11-20 JP JP2008540534A patent/JP2009515922A/ja not_active Withdrawn
-
2007
- 2007-08-08 IL IL185129A patent/IL185129A0/en unknown
- 2007-08-15 NO NO20074188A patent/NO20074188L/no not_active Application Discontinuation
-
2008
- 2008-12-12 US US12/334,124 patent/US20090093636A1/en not_active Abandoned
-
2009
- 2009-10-09 US US12/576,773 patent/US20100099879A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009515922A (ja) | 2009-04-16 |
| EP1960362A1 (de) | 2008-08-27 |
| US7601741B2 (en) | 2009-10-13 |
| WO2007057225A2 (en) | 2007-05-24 |
| US7786138B2 (en) | 2010-08-31 |
| AR057908A1 (es) | 2007-12-26 |
| US20070135480A1 (en) | 2007-06-14 |
| DE602006019979D1 (de) | 2011-03-17 |
| US20070135642A1 (en) | 2007-06-14 |
| AU2006314726A1 (en) | 2007-05-24 |
| PT1954679E (pt) | 2011-05-05 |
| AR056815A1 (es) | 2007-10-24 |
| AR057909A1 (es) | 2007-12-26 |
| AU2006314729A1 (en) | 2007-05-24 |
| CA2629840A1 (en) | 2007-05-24 |
| US20090093636A1 (en) | 2009-04-09 |
| EP1954679A1 (de) | 2008-08-13 |
| CA2598093A1 (en) | 2007-05-24 |
| NO20074188L (no) | 2008-08-13 |
| CA2629834A1 (en) | 2007-05-24 |
| WO2007057227A1 (en) | 2007-05-24 |
| ATE497493T1 (de) | 2011-02-15 |
| US20100099879A1 (en) | 2010-04-22 |
| EP1954679B1 (de) | 2011-02-02 |
| WO2007057225A3 (en) | 2007-07-26 |
| WO2007057228A1 (en) | 2007-05-24 |
| US20070135643A1 (en) | 2007-06-14 |
| US7476748B2 (en) | 2009-01-13 |
| AU2006314728A1 (en) | 2007-05-24 |
| EP1948610A2 (de) | 2008-07-30 |
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