PT1954679E - Novo intermedi?rio para produzir montelukast e compostos relacionados - Google Patents
Novo intermedi?rio para produzir montelukast e compostos relacionados Download PDFInfo
- Publication number
- PT1954679E PT1954679E PT06818694T PT06818694T PT1954679E PT 1954679 E PT1954679 E PT 1954679E PT 06818694 T PT06818694 T PT 06818694T PT 06818694 T PT06818694 T PT 06818694T PT 1954679 E PT1954679 E PT 1954679E
- Authority
- PT
- Portugal
- Prior art keywords
- related compounds
- new intermediate
- making montelukast
- montelukast
- making
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/75—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73775205P | 2005-11-18 | 2005-11-18 | |
| US79442906P | 2006-04-24 | 2006-04-24 | |
| US82438206P | 2006-09-01 | 2006-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1954679E true PT1954679E (pt) | 2011-05-05 |
Family
ID=37685804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06818694T PT1954679E (pt) | 2005-11-18 | 2006-11-20 | Novo intermedi?rio para produzir montelukast e compostos relacionados |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US7601741B2 (pt) |
| EP (3) | EP1954679B1 (pt) |
| JP (1) | JP2009515922A (pt) |
| AR (3) | AR057909A1 (pt) |
| AT (1) | ATE497493T1 (pt) |
| AU (3) | AU2006314728A1 (pt) |
| CA (3) | CA2629834A1 (pt) |
| DE (1) | DE602006019979D1 (pt) |
| IL (1) | IL185129A0 (pt) |
| NO (1) | NO20074188L (pt) |
| PT (1) | PT1954679E (pt) |
| WO (3) | WO2007057227A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006054317A1 (en) * | 2004-11-19 | 2006-05-26 | Matrix Laboratories Ltd | Process for the preparation of novel amorphous montelukast sodium |
| ES2358923T3 (es) | 2005-07-05 | 2011-05-16 | Teva Pharmaceutical Industries, Ltd. | Purificación de montelukast. |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
| EP2014650A1 (en) * | 2007-07-13 | 2009-01-14 | Lonza Ag | Process and intermediate for the production of an intermediate in the production of montelukast |
| ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
| CN102046602A (zh) * | 2008-04-25 | 2011-05-04 | 斯索恩有限公司 | 制备孟鲁司特中间体的方法 |
| EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| EP2566474B1 (en) | 2010-05-03 | 2017-11-15 | Teikoku Pharma USA, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| TWI450275B (zh) * | 2010-05-19 | 2014-08-21 | Wistron Corp | 可提升寫入保護之記憶體系統及相關方法 |
| US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
| EP2502910A1 (en) | 2011-03-15 | 2012-09-26 | Laboratorios Lesvi, S.L. | Camphorsulfonic salt of a key Montelukast intermediate |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU199796B (en) * | 1985-08-06 | 1990-03-28 | Boehringer Biochemia Srl | Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds |
| CA2038178A1 (en) | 1990-04-05 | 1991-10-06 | Carl C. Greco | Niobium alkoxyalkoxides and process for formation |
| CA2053216C (en) * | 1990-10-12 | 2003-04-08 | Michel L. Belley | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5856322A (en) | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| CA2053209C (en) | 1990-10-12 | 1998-12-08 | Michel L. Belley | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5266568A (en) | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
| IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
| US5270324A (en) | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
| TW448160B (en) | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| GB9423511D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| US5523477A (en) | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
| US5869673A (en) | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
| CN1420113A (zh) | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
| CN1171873C (zh) * | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| ES2371549T3 (es) | 2003-10-10 | 2012-01-05 | Synthon B.V. | Montelukast en estado sólido. |
| WO2005074935A1 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
| US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
| ATE500225T1 (de) * | 2004-07-19 | 2011-03-15 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen davon |
| ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
-
2006
- 2006-11-17 AR ARP060105063A patent/AR057909A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105062A patent/AR057908A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105061A patent/AR056815A1/es not_active Application Discontinuation
- 2006-11-20 EP EP06818694A patent/EP1954679B1/en not_active Not-in-force
- 2006-11-20 CA CA002629834A patent/CA2629834A1/en not_active Abandoned
- 2006-11-20 PT PT06818694T patent/PT1954679E/pt unknown
- 2006-11-20 WO PCT/EP2006/011133 patent/WO2007057227A1/en active Application Filing
- 2006-11-20 AT AT06818694T patent/ATE497493T1/de not_active IP Right Cessation
- 2006-11-20 CA CA002598093A patent/CA2598093A1/en not_active Abandoned
- 2006-11-20 WO PCT/EP2006/011127 patent/WO2007057225A2/en active Application Filing
- 2006-11-20 WO PCT/EP2006/011134 patent/WO2007057228A1/en active Application Filing
- 2006-11-20 JP JP2008540534A patent/JP2009515922A/ja not_active Withdrawn
- 2006-11-20 DE DE602006019979T patent/DE602006019979D1/de active Active
- 2006-11-20 US US11/561,724 patent/US7601741B2/en not_active Expired - Fee Related
- 2006-11-20 AU AU2006314728A patent/AU2006314728A1/en not_active Abandoned
- 2006-11-20 EP EP06818693A patent/EP1960362A1/en not_active Withdrawn
- 2006-11-20 CA CA002629840A patent/CA2629840A1/en not_active Abandoned
- 2006-11-20 EP EP06818691A patent/EP1948610A2/en not_active Withdrawn
- 2006-11-20 AU AU2006314729A patent/AU2006314729A1/en not_active Abandoned
- 2006-11-20 US US11/561,689 patent/US7476748B2/en not_active Expired - Fee Related
- 2006-11-20 AU AU2006314726A patent/AU2006314726A1/en not_active Abandoned
- 2006-11-20 US US11/561,732 patent/US7786138B2/en not_active Expired - Fee Related
-
2007
- 2007-08-08 IL IL185129A patent/IL185129A0/en unknown
- 2007-08-15 NO NO20074188A patent/NO20074188L/no not_active Application Discontinuation
-
2008
- 2008-12-12 US US12/334,124 patent/US20090093636A1/en not_active Abandoned
-
2009
- 2009-10-09 US US12/576,773 patent/US20100099879A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR056815A1 (es) | 2007-10-24 |
| US20070135643A1 (en) | 2007-06-14 |
| AR057908A1 (es) | 2007-12-26 |
| WO2007057225A3 (en) | 2007-07-26 |
| EP1960362A1 (en) | 2008-08-27 |
| US20090093636A1 (en) | 2009-04-09 |
| JP2009515922A (ja) | 2009-04-16 |
| WO2007057227A1 (en) | 2007-05-24 |
| US7476748B2 (en) | 2009-01-13 |
| WO2007057228A1 (en) | 2007-05-24 |
| EP1948610A2 (en) | 2008-07-30 |
| CA2598093A1 (en) | 2007-05-24 |
| US20100099879A1 (en) | 2010-04-22 |
| US7601741B2 (en) | 2009-10-13 |
| NO20074188L (no) | 2008-08-13 |
| ATE497493T1 (de) | 2011-02-15 |
| US20070135480A1 (en) | 2007-06-14 |
| CA2629840A1 (en) | 2007-05-24 |
| EP1954679A1 (en) | 2008-08-13 |
| US20070135642A1 (en) | 2007-06-14 |
| DE602006019979D1 (de) | 2011-03-17 |
| CA2629834A1 (en) | 2007-05-24 |
| AR057909A1 (es) | 2007-12-26 |
| EP1954679B1 (en) | 2011-02-02 |
| AU2006314729A1 (en) | 2007-05-24 |
| WO2007057225A2 (en) | 2007-05-24 |
| AU2006314728A1 (en) | 2007-05-24 |
| AU2006314726A1 (en) | 2007-05-24 |
| IL185129A0 (en) | 2007-12-03 |
| US7786138B2 (en) | 2010-08-31 |
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