IL166533A0 - 2-substituted bicyclic benzoheterocylic compounds and their use as sodium channel blockers - Google Patents
2-substituted bicyclic benzoheterocylic compounds and their use as sodium channel blockersInfo
- Publication number
- IL166533A0 IL166533A0 IL16653303A IL16653303A IL166533A0 IL 166533 A0 IL166533 A0 IL 166533A0 IL 16653303 A IL16653303 A IL 16653303A IL 16653303 A IL16653303 A IL 16653303A IL 166533 A0 IL166533 A0 IL 166533A0
- Authority
- IL
- Israel
- Prior art keywords
- benzoheterocylic
- compounds
- sodium channel
- channel blockers
- substituted bicyclic
- Prior art date
Links
- 125000002619 bicyclic group Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003195 sodium channel blocking agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39970202P | 2002-08-01 | 2002-08-01 | |
| PCT/US2003/023791 WO2004013111A1 (en) | 2002-08-01 | 2003-07-30 | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166533A0 true IL166533A0 (en) | 2006-01-15 |
Family
ID=31495754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16653303A IL166533A0 (en) | 2002-08-01 | 2003-07-30 | 2-substituted bicyclic benzoheterocylic compounds and their use as sodium channel blockers |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040152696A1 (de) |
| EP (1) | EP1534690A1 (de) |
| JP (1) | JP2006500343A (de) |
| KR (1) | KR20050026094A (de) |
| CN (1) | CN1678592A (de) |
| AU (1) | AU2003257015A1 (de) |
| BR (1) | BR0313369A (de) |
| CA (1) | CA2493737A1 (de) |
| IL (1) | IL166533A0 (de) |
| MX (1) | MXPA05001288A (de) |
| WO (1) | WO2004013111A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR065081A1 (es) * | 2007-01-29 | 2009-05-13 | Xenon Pharmaceuticals Inc | Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica |
| JP2013531687A (ja) | 2010-07-16 | 2013-08-08 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリジン化合物 |
| AU2011303597A1 (en) | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| KR20130095772A (ko) | 2010-10-05 | 2013-08-28 | 퍼듀 퍼머 엘피 | 나트륨 채널 차단제로서 퀴나졸린 화합물 |
| EP2655330B1 (de) | 2010-12-22 | 2016-02-10 | Purdue Pharma LP | Substutuierte pyridine als kaliumkanalblocker |
| UY34171A (es) * | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| EP3255041A1 (de) | 2011-09-02 | 2017-12-13 | Purdue Pharma L.P. | Pyrimidine als natriumkanalblocker |
| WO2013064883A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| WO2013064884A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| EP2925719A4 (de) | 2012-11-28 | 2016-07-13 | Yansong Lu | Neuartige synthetische antioxidantien und deren verwendungen |
| EP2935257B1 (de) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Cyclische sulfonamide als natriumkanalblocker |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| WO2014135955A1 (en) | 2013-03-04 | 2014-09-12 | Purdue Pharma L.P. | Pyrimidine carboxamides as sodium channel blockers |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| CN105612152A (zh) | 2013-08-26 | 2016-05-25 | 普渡制药公司 | 氮杂螺[4.5]癸烷衍生物及其用途 |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| JP6337124B2 (ja) | 2013-12-23 | 2018-06-06 | パーデュー、ファーマ、リミテッド、パートナーシップ | インダゾール及びその使用 |
| EP3089978B1 (de) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridonsulfonmorphinan-analoga als opioidrezeptorliganden |
| JP6526023B2 (ja) | 2014-01-24 | 2019-06-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン類及びピリミジン類並びにその使用 |
| AU2015217185B2 (en) | 2014-02-12 | 2018-04-05 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| MA40171A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CN117756744B (zh) * | 2023-12-14 | 2025-11-25 | 常州大学 | 一种2-取代的-2,3-二氢-4h-苯并噻嗪-4-酮的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3322766A (en) * | 1964-11-13 | 1967-05-30 | Shulton Inc | 3-beta-(4-pyridyl) ethyl-2, 3-dihydro-4(1h)-quinazolinones |
| US3459748A (en) * | 1967-04-28 | 1969-08-05 | Squibb & Sons Inc | Hydroxyalkylene-substituted benzoxazines and benzothiazines |
| WO2001023365A1 (en) * | 1999-09-28 | 2001-04-05 | Merck Patent Gmbh | Quinazolinones |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| AU4589701A (en) * | 2000-03-24 | 2001-10-08 | Cocensys Inc | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof |
| AU4961001A (en) * | 2000-03-31 | 2001-10-15 | Cocensys Inc | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| IL159765A0 (en) * | 2001-07-16 | 2004-06-20 | Euro Celtique Sa | Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same |
| AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| MXPA04008901A (es) * | 2002-03-13 | 2004-11-26 | Euro Celtique Sa | Pirimidinas arilo sustituidas y el uso de las mismas. |
-
2003
- 2003-07-29 US US10/628,487 patent/US20040152696A1/en not_active Abandoned
- 2003-07-30 JP JP2004526225A patent/JP2006500343A/ja active Pending
- 2003-07-30 KR KR1020057001811A patent/KR20050026094A/ko not_active Withdrawn
- 2003-07-30 MX MXPA05001288A patent/MXPA05001288A/es unknown
- 2003-07-30 EP EP03766980A patent/EP1534690A1/de not_active Withdrawn
- 2003-07-30 CA CA002493737A patent/CA2493737A1/en not_active Abandoned
- 2003-07-30 BR BR0313369-9A patent/BR0313369A/pt not_active Application Discontinuation
- 2003-07-30 IL IL16653303A patent/IL166533A0/xx unknown
- 2003-07-30 WO PCT/US2003/023791 patent/WO2004013111A1/en not_active Ceased
- 2003-07-30 CN CNA038207427A patent/CN1678592A/zh active Pending
- 2003-07-30 AU AU2003257015A patent/AU2003257015A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2493737A1 (en) | 2004-02-12 |
| US20040152696A1 (en) | 2004-08-05 |
| MXPA05001288A (es) | 2005-09-08 |
| AU2003257015A1 (en) | 2004-02-23 |
| EP1534690A1 (de) | 2005-06-01 |
| BR0313369A (pt) | 2005-06-21 |
| CN1678592A (zh) | 2005-10-05 |
| JP2006500343A (ja) | 2006-01-05 |
| WO2004013111A1 (en) | 2004-02-12 |
| KR20050026094A (ko) | 2005-03-14 |
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