IL165943A0 - Functional cardiomyocytes from human embryonic stem cells - Google Patents
Functional cardiomyocytes from human embryonic stem cellsInfo
- Publication number
- IL165943A0 IL165943A0 IL16594304A IL16594304A IL165943A0 IL 165943 A0 IL165943 A0 IL 165943A0 IL 16594304 A IL16594304 A IL 16594304A IL 16594304 A IL16594304 A IL 16594304A IL 165943 A0 IL165943 A0 IL 165943A0
- Authority
- IL
- Israel
- Prior art keywords
- stem cells
- embryonic stem
- human embryonic
- functional cardiomyocytes
- cardiomyocytes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39933002P | 2002-07-26 | 2002-07-26 | |
| PCT/US2003/023174 WO2004011603A2 (en) | 2002-07-26 | 2003-07-25 | Functional cardiomyocytes from human embryonic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165943A0 true IL165943A0 (en) | 2006-01-15 |
Family
ID=31188569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16594304A IL165943A0 (en) | 2002-07-26 | 2004-12-22 | Functional cardiomyocytes from human embryonic stem cells |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7611852B2 (de) |
| EP (1) | EP1551991A4 (de) |
| JP (1) | JP2005533518A (de) |
| KR (1) | KR20050026008A (de) |
| CN (1) | CN1671860A (de) |
| AU (1) | AU2003252155B2 (de) |
| BR (1) | BR0312764A (de) |
| CA (1) | CA2493588C (de) |
| IL (1) | IL165943A0 (de) |
| IS (1) | IS7663A (de) |
| MX (1) | MXPA05000283A (de) |
| NO (1) | NO20051030L (de) |
| NZ (1) | NZ537245A (de) |
| WO (1) | WO2004011603A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1444326A4 (de) * | 2001-08-24 | 2006-06-28 | Advanced Cell Tech Inc | Screening-assays zur identifizierung differenzierung induzierender stoffe und herstellung differenzierter zellen zur zelltherapie |
| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| US9612234B2 (en) | 2008-05-05 | 2017-04-04 | Acea Biosciences, Inc. | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments |
| AU2003901099A0 (en) * | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
| CA2550274A1 (en) | 2003-11-12 | 2005-05-26 | Acea Biosciences, Inc. | Real time electronic cell sensing systems and applications for cell-based assays |
| CA2560334A1 (en) | 2004-04-07 | 2005-10-20 | Axiogenesis Ag | Non-invasive, in vitro functional tissue assay systems |
| CA2565858C (en) | 2004-05-11 | 2021-06-22 | Axiogenesis Ag | Assay for drug discovery based on in vitro differentiated cells |
| US20050277124A1 (en) | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
| WO2008090472A2 (en) * | 2007-01-25 | 2008-07-31 | Uti Limited Partnership | Tissue progenitor cells that overexpress erg |
| WO2008112323A1 (en) * | 2007-03-15 | 2008-09-18 | California Stem Cell, Inc. | Cardiomyocytes and methods of producing and purifying cardiomyocytes |
| WO2008152983A1 (ja) * | 2007-06-08 | 2008-12-18 | National University Corporation Tokyo Medical And Dental University | モデル細胞チップ、モデル細胞チップによる薬効評価装置、および薬効評価方法 |
| EP2291645B1 (de) | 2008-05-05 | 2015-09-09 | Acea Biosciences, Inc. | Markierungsfreie überwachung der elektromechanischen kopplung und erregbaren zellen anhand von systemen auf impedanzbasis mit millisekunden-zeitauflösung |
| US8603817B2 (en) * | 2008-11-03 | 2013-12-10 | University Of Washington | Induction of human embryonic stem cell derived cardiac pacemaker or chamber-type cardiomyocytes by manipulation of neuregulin signaling |
| EP2218772A1 (de) | 2009-02-09 | 2010-08-18 | Koninklijke Philips Electronics N.V. | Vorrichtung mit Herzmuskelzellen und deren Herstellung |
| WO2010094694A1 (en) * | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Assays to predict cardiotoxicity |
| CA2802526C (en) * | 2010-06-13 | 2021-11-16 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
| WO2012017343A2 (en) * | 2010-08-05 | 2012-02-09 | Koninklijke Philips Electronics N.V. | Cardiomyocyte containing device, manufacturing method and measuring method |
| KR101364965B1 (ko) * | 2010-10-06 | 2014-02-18 | (주)차바이오앤디오스텍 | 인간 배아줄기세포 유래 심근세포의 배양 및 정제 방법 |
| JP6133210B2 (ja) * | 2010-10-29 | 2017-05-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 不整脈のリスクを判定する方法 |
| WO2013006364A1 (en) | 2011-07-05 | 2013-01-10 | Baylor Research Institute | Establishment of patient - or person - specific cardiac myocyte cell lines from human induced pluripotent stem cells (ipscs) |
| JP6388537B2 (ja) | 2011-07-21 | 2018-09-12 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 患者由来の人工多能性幹細胞由来の心筋細胞および使用方法 |
| CN104237308B (zh) * | 2013-06-09 | 2016-08-31 | 国家纳米科学中心 | 一种在体外筛选药物的方法 |
| US9983198B2 (en) | 2015-03-19 | 2018-05-29 | Axion Biosystems, Inc. | Systems and methods for assessing data collected from an electrically active cell culture |
| WO2017147536A1 (en) | 2016-02-24 | 2017-08-31 | The Rockefeller University | Embryonic cell-based therapeutic candidate screening systems, models for huntington's disease and uses thereof |
| EP3589299A4 (de) * | 2017-03-03 | 2021-01-13 | ACEA Biosciences, Inc. | Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc |
| USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4441327C1 (de) * | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung |
| DE19727962A1 (de) * | 1997-07-02 | 1999-01-14 | Juergen Hescheler | Fluoreszierende Proteine als zelltypspezifische Reporter |
| DE19843234A1 (de) * | 1998-09-09 | 2000-03-23 | Inst Pflanzengenetik & Kultur | Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen |
| WO2003008535A2 (en) * | 2001-07-20 | 2003-01-30 | Technion Research And Development Foundation Ltd. | Methods of generating human cardiac cells and tissues and uses thereof |
| US20050244384A1 (en) | 2002-04-01 | 2005-11-03 | Law Peter K | Cellular transplantation for heart regeneration |
-
2003
- 2003-07-25 EP EP03771801A patent/EP1551991A4/de not_active Withdrawn
- 2003-07-25 US US10/627,245 patent/US7611852B2/en active Active
- 2003-07-25 NZ NZ537245A patent/NZ537245A/en not_active IP Right Cessation
- 2003-07-25 CA CA2493588A patent/CA2493588C/en not_active Expired - Lifetime
- 2003-07-25 JP JP2004524781A patent/JP2005533518A/ja active Pending
- 2003-07-25 MX MXPA05000283A patent/MXPA05000283A/es unknown
- 2003-07-25 WO PCT/US2003/023174 patent/WO2004011603A2/en active Application Filing
- 2003-07-25 AU AU2003252155A patent/AU2003252155B2/en not_active Expired
- 2003-07-25 BR BR0312764-8A patent/BR0312764A/pt not_active Application Discontinuation
- 2003-07-25 CN CNA038179032A patent/CN1671860A/zh active Pending
- 2003-07-25 KR KR1020057001457A patent/KR20050026008A/ko not_active Application Discontinuation
-
2004
- 2004-12-22 IL IL16594304A patent/IL165943A0/xx active IP Right Grant
-
2005
- 2005-01-25 IS IS7663A patent/IS7663A/is unknown
- 2005-02-25 NO NO20051030A patent/NO20051030L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003252155A1 (en) | 2004-02-16 |
| JP2005533518A (ja) | 2005-11-10 |
| KR20050026008A (ko) | 2005-03-14 |
| EP1551991A2 (de) | 2005-07-13 |
| NZ537245A (en) | 2010-04-30 |
| CA2493588A1 (en) | 2004-02-05 |
| IS7663A (is) | 2005-01-25 |
| WO2004011603A2 (en) | 2004-02-05 |
| CA2493588C (en) | 2012-09-11 |
| US7611852B2 (en) | 2009-11-03 |
| AU2003252155B2 (en) | 2009-01-22 |
| EP1551991A4 (de) | 2006-09-20 |
| BR0312764A (pt) | 2005-07-26 |
| MXPA05000283A (es) | 2005-03-31 |
| CN1671860A (zh) | 2005-09-21 |
| WO2004011603A3 (en) | 2004-07-08 |
| US20040106095A1 (en) | 2004-06-03 |
| NO20051030L (no) | 2005-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |