IL163698A0 - Improved method for the production of 4-(6-bromohexyloxy)butylbenzene - Google Patents

Improved method for the production of 4-(6-bromohexyloxy)butylbenzene

Info

Publication number
IL163698A0
IL163698A0 IL16369803A IL16369803A IL163698A0 IL 163698 A0 IL163698 A0 IL 163698A0 IL 16369803 A IL16369803 A IL 16369803A IL 16369803 A IL16369803 A IL 16369803A IL 163698 A0 IL163698 A0 IL 163698A0
Authority
IL
Israel
Prior art keywords
bromohexyloxy
butylbenzene
improved method
production
phenylbutanol
Prior art date
Application number
IL16369803A
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL163698A0 publication Critical patent/IL163698A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.
IL16369803A 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy)butylbenzene IL163698A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10209583A DE10209583B4 (en) 2002-03-05 2002-03-05 Process for the preparation of 4- (6-bromohexyloxy) -butylbenzene
PCT/EP2003/002054 WO2003074458A1 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy) butylbenzene

Publications (1)

Publication Number Publication Date
IL163698A0 true IL163698A0 (en) 2005-12-18

Family

ID=27770986

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16369803A IL163698A0 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy)butylbenzene
IL163698A IL163698A (en) 2002-03-05 2004-08-24 Method for the production of 4-(6-bromohexyloxy) butylbenzene

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL163698A IL163698A (en) 2002-03-05 2004-08-24 Method for the production of 4-(6-bromohexyloxy) butylbenzene

Country Status (9)

Country Link
EP (1) EP1483226B1 (en)
JP (1) JP4424992B2 (en)
AT (1) ATE303981T1 (en)
AU (1) AU2003227527A1 (en)
CA (1) CA2477862C (en)
DE (2) DE10209583B4 (en)
ES (1) ES2248747T3 (en)
IL (2) IL163698A0 (en)
WO (1) WO2003074458A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
WO1995019336A1 (en) * 1994-01-12 1995-07-20 Iovis Biomedical And Pharmaceutical Consultants PHENYL ETHANOL AMINE ETHERS AND USES THEREOF AS β-ADRENO-RECEPTOR AGONISTS
ES2142771B1 (en) * 1998-09-28 2001-01-01 Vita Invest Sa NEW DERIVATIVES OF 6- (4-PHENYL-BUTOXI) HEXYLAMINE AND PROCEDURE FOR OBTAINING SALMETEROL.

Also Published As

Publication number Publication date
EP1483226B1 (en) 2005-09-07
WO2003074458A1 (en) 2003-09-12
CA2477862A1 (en) 2003-09-12
DE50301150D1 (en) 2005-10-13
ATE303981T1 (en) 2005-09-15
DE10209583A1 (en) 2003-09-25
EP1483226A1 (en) 2004-12-08
CA2477862C (en) 2011-04-05
JP4424992B2 (en) 2010-03-03
ES2248747T3 (en) 2006-03-16
IL163698A (en) 2010-11-30
JP2005526742A (en) 2005-09-08
DE10209583B4 (en) 2006-01-19
AU2003227527A1 (en) 2003-09-16

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