IL163698A - Method for the production of 4-(6-bromohexyloxy) butylbenzene - Google Patents

Method for the production of 4-(6-bromohexyloxy) butylbenzene

Info

Publication number
IL163698A
IL163698A IL163698A IL16369804A IL163698A IL 163698 A IL163698 A IL 163698A IL 163698 A IL163698 A IL 163698A IL 16369804 A IL16369804 A IL 16369804A IL 163698 A IL163698 A IL 163698A
Authority
IL
Israel
Prior art keywords
bromohexyloxy
butylbenzene
production
phenylbutanol
dibromohexane
Prior art date
Application number
IL163698A
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL163698A publication Critical patent/IL163698A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups

Abstract

The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.
IL163698A 2002-03-05 2004-08-24 Method for the production of 4-(6-bromohexyloxy) butylbenzene IL163698A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10209583A DE10209583B4 (en) 2002-03-05 2002-03-05 Process for the preparation of 4- (6-bromohexyloxy) -butylbenzene
PCT/EP2003/002054 WO2003074458A1 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy) butylbenzene

Publications (1)

Publication Number Publication Date
IL163698A true IL163698A (en) 2010-11-30

Family

ID=27770986

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16369803A IL163698A0 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy)butylbenzene
IL163698A IL163698A (en) 2002-03-05 2004-08-24 Method for the production of 4-(6-bromohexyloxy) butylbenzene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL16369803A IL163698A0 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy)butylbenzene

Country Status (9)

Country Link
EP (1) EP1483226B1 (en)
JP (1) JP4424992B2 (en)
AT (1) ATE303981T1 (en)
AU (1) AU2003227527A1 (en)
CA (1) CA2477862C (en)
DE (2) DE10209583B4 (en)
ES (1) ES2248747T3 (en)
IL (2) IL163698A0 (en)
WO (1) WO2003074458A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
WO1995019336A1 (en) * 1994-01-12 1995-07-20 Iovis Biomedical And Pharmaceutical Consultants PHENYL ETHANOL AMINE ETHERS AND USES THEREOF AS β-ADRENO-RECEPTOR AGONISTS
ES2142771B1 (en) * 1998-09-28 2001-01-01 Vita Invest Sa NEW DERIVATIVES OF 6- (4-PHENYL-BUTOXI) HEXYLAMINE AND PROCEDURE FOR OBTAINING SALMETEROL.

Also Published As

Publication number Publication date
EP1483226B1 (en) 2005-09-07
WO2003074458A1 (en) 2003-09-12
CA2477862A1 (en) 2003-09-12
DE50301150D1 (en) 2005-10-13
ATE303981T1 (en) 2005-09-15
DE10209583A1 (en) 2003-09-25
EP1483226A1 (en) 2004-12-08
CA2477862C (en) 2011-04-05
JP4424992B2 (en) 2010-03-03
ES2248747T3 (en) 2006-03-16
IL163698A0 (en) 2005-12-18
JP2005526742A (en) 2005-09-08
DE10209583B4 (en) 2006-01-19
AU2003227527A1 (en) 2003-09-16

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