AU2003227527A1 - Improved method for the production of 4-(6-bromohexyloxy) butylbenzene - Google Patents

Improved method for the production of 4-(6-bromohexyloxy) butylbenzene

Info

Publication number
AU2003227527A1
AU2003227527A1 AU2003227527A AU2003227527A AU2003227527A1 AU 2003227527 A1 AU2003227527 A1 AU 2003227527A1 AU 2003227527 A AU2003227527 A AU 2003227527A AU 2003227527 A AU2003227527 A AU 2003227527A AU 2003227527 A1 AU2003227527 A1 AU 2003227527A1
Authority
AU
Australia
Prior art keywords
bromohexyloxy
butylbenzene
improved method
production
phenylbutanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003227527A
Inventor
Helmut Heitger
Oliver Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2003227527A1 publication Critical patent/AU2003227527A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.
AU2003227527A 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy) butylbenzene Abandoned AU2003227527A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10209583A DE10209583B4 (en) 2002-03-05 2002-03-05 Process for the preparation of 4- (6-bromohexyloxy) -butylbenzene
DE10209583.3 2002-03-05
PCT/EP2003/002054 WO2003074458A1 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy) butylbenzene

Publications (1)

Publication Number Publication Date
AU2003227527A1 true AU2003227527A1 (en) 2003-09-16

Family

ID=27770986

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003227527A Abandoned AU2003227527A1 (en) 2002-03-05 2003-02-28 Improved method for the production of 4-(6-bromohexyloxy) butylbenzene

Country Status (9)

Country Link
EP (1) EP1483226B1 (en)
JP (1) JP4424992B2 (en)
AT (1) ATE303981T1 (en)
AU (1) AU2003227527A1 (en)
CA (1) CA2477862C (en)
DE (2) DE10209583B4 (en)
ES (1) ES2248747T3 (en)
IL (2) IL163698A0 (en)
WO (1) WO2003074458A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
AU1533495A (en) * 1994-01-12 1995-08-01 Byk Nederland Bv Phenyl ethanol amine ethers and uses thereof as beta-adreno-receptor agonists
ES2142771B1 (en) * 1998-09-28 2001-01-01 Vita Invest Sa NEW DERIVATIVES OF 6- (4-PHENYL-BUTOXI) HEXYLAMINE AND PROCEDURE FOR OBTAINING SALMETEROL.

Also Published As

Publication number Publication date
DE10209583B4 (en) 2006-01-19
DE50301150D1 (en) 2005-10-13
WO2003074458A1 (en) 2003-09-12
JP2005526742A (en) 2005-09-08
EP1483226A1 (en) 2004-12-08
ATE303981T1 (en) 2005-09-15
IL163698A0 (en) 2005-12-18
IL163698A (en) 2010-11-30
DE10209583A1 (en) 2003-09-25
EP1483226B1 (en) 2005-09-07
CA2477862C (en) 2011-04-05
ES2248747T3 (en) 2006-03-16
JP4424992B2 (en) 2010-03-03
CA2477862A1 (en) 2003-09-12

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase