IL149064A0 - Method for protecting normal cells from cytotoxicity of chemotherapeutic agents - Google Patents
Method for protecting normal cells from cytotoxicity of chemotherapeutic agentsInfo
- Publication number
- IL149064A0 IL149064A0 IL14906400A IL14906400A IL149064A0 IL 149064 A0 IL149064 A0 IL 149064A0 IL 14906400 A IL14906400 A IL 14906400A IL 14906400 A IL14906400 A IL 14906400A IL 149064 A0 IL149064 A0 IL 149064A0
- Authority
- IL
- Israel
- Prior art keywords
- normal cells
- anticancer
- cytotoxicity
- chemotherapeutic agents
- alpha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15912399P | 1999-10-12 | 1999-10-12 | |
PCT/US2000/028250 WO2001026645A1 (en) | 1999-10-12 | 2000-10-11 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL149064A0 true IL149064A0 (en) | 2002-11-10 |
Family
ID=22571170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14906400A IL149064A0 (en) | 1999-10-12 | 2000-10-11 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1223923B1 (xx) |
JP (1) | JP4780885B2 (xx) |
AT (1) | ATE462423T1 (xx) |
AU (1) | AU780844B2 (xx) |
CA (1) | CA2387539C (xx) |
DE (1) | DE60044092D1 (xx) |
IL (1) | IL149064A0 (xx) |
WO (1) | WO2001026645A1 (xx) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
EP1173160B1 (en) * | 1999-04-02 | 2005-06-22 | Temple University of the Commonwealth System of Higher Education | (e)-styryl sulfone anticancer agents |
US6486210B2 (en) * | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
US6541475B2 (en) * | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
EP1328511B1 (en) | 2000-10-05 | 2010-03-24 | Temple University of the Commonwealth System of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
US6833480B2 (en) | 2001-02-27 | 2004-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof |
AU2002305942B2 (en) * | 2001-02-28 | 2006-10-26 | Onconova Therapeutics, Inc. | Method for protecting cells and tissues from ionizing radiation toxicity with Alpha, Beta unsaturated aryl sulfones |
CA2477232C (en) * | 2002-02-28 | 2011-07-19 | Temple University - Of The Commonwealth System Of Higher Education | Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
EP1689706B1 (en) * | 2003-11-14 | 2017-01-11 | Temple University - Of The Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
WO2007016201A2 (en) * | 2005-07-29 | 2007-02-08 | Onconova Therapeutics, Inc. | FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES |
EP2091527B1 (en) * | 2006-12-13 | 2016-03-23 | Temple University - Of The Commonwealth System of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
WO2021007840A1 (zh) * | 2019-07-18 | 2021-01-21 | 华夏生生药业(北京)有限公司 | 氨基甲酸酯取代的苯乙烯基砜类化合物及其制备方法和用途 |
CN111253935B (zh) * | 2019-12-24 | 2022-12-13 | 安徽大学 | 一种双通道检测极性和粘度的双光子荧光探针及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT93772A (pt) * | 1989-04-17 | 1991-01-08 | Searle & Co | Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer |
EP0439421A1 (de) * | 1990-01-23 | 1991-07-31 | Ciba-Geigy Ag | Mikrobizide Mittel |
WO1996040629A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders |
IL119069A0 (en) * | 1996-08-14 | 1996-11-14 | Mor Research Applic Ltd | Pharmaceutical composition comprising tyrphostins |
IL135438A (en) * | 1997-10-03 | 2005-12-18 | Univ Temple | Pharmaceutical compositions containing styrl sulfones and some such novel styryl sulfone compounds with anticancer activity |
-
2000
- 2000-10-11 AT AT00973486T patent/ATE462423T1/de not_active IP Right Cessation
- 2000-10-11 WO PCT/US2000/028250 patent/WO2001026645A1/en active IP Right Grant
- 2000-10-11 CA CA2387539A patent/CA2387539C/en not_active Expired - Lifetime
- 2000-10-11 EP EP00973486A patent/EP1223923B1/en not_active Expired - Lifetime
- 2000-10-11 AU AU11989/01A patent/AU780844B2/en not_active Expired
- 2000-10-11 IL IL14906400A patent/IL149064A0/xx active IP Right Grant
- 2000-10-11 DE DE60044092T patent/DE60044092D1/de not_active Expired - Lifetime
- 2000-10-11 JP JP2001529435A patent/JP4780885B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001026645A1 (en) | 2001-04-19 |
JP4780885B2 (ja) | 2011-09-28 |
JP2003511412A (ja) | 2003-03-25 |
EP1223923A1 (en) | 2002-07-24 |
AU1198901A (en) | 2001-04-23 |
CA2387539A1 (en) | 2001-04-19 |
DE60044092D1 (de) | 2010-05-12 |
ATE462423T1 (de) | 2010-04-15 |
EP1223923A4 (en) | 2007-09-05 |
AU780844B2 (en) | 2005-04-21 |
CA2387539C (en) | 2010-09-21 |
EP1223923B1 (en) | 2010-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed |