IL148152A0 - Sequence-specific dna recombination in eukaryotic cells - Google Patents

Sequence-specific dna recombination in eukaryotic cells

Info

Publication number
IL148152A0
IL148152A0 IL14815200A IL14815200A IL148152A0 IL 148152 A0 IL148152 A0 IL 148152A0 IL 14815200 A IL14815200 A IL 14815200A IL 14815200 A IL14815200 A IL 14815200A IL 148152 A0 IL148152 A0 IL 148152A0
Authority
IL
Israel
Prior art keywords
sequence
derivatives
eukaryotic cells
specific dna
dna recombination
Prior art date
Application number
IL14815200A
Other languages
English (en)
Original Assignee
Droge Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Droge Peter filed Critical Droge Peter
Publication of IL148152A0 publication Critical patent/IL148152A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14815200A 1999-08-30 2000-08-29 Sequence-specific dna recombination in eukaryotic cells IL148152A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19941186A DE19941186A1 (de) 1999-08-30 1999-08-30 Sequenz-spezifische DNA-Rekombination in eukaryotischen Zellen
PCT/DE2000/002947 WO2001016345A2 (de) 1999-08-30 2000-08-29 Sequenz-spezifische dna-rekombination in eukaryotischen zellen

Publications (1)

Publication Number Publication Date
IL148152A0 true IL148152A0 (en) 2002-09-12

Family

ID=7920135

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14815200A IL148152A0 (en) 1999-08-30 2000-08-29 Sequence-specific dna recombination in eukaryotic cells
IL148152A IL148152A (en) 1999-08-30 2002-02-14 DNA recombination with a unique sequence in eukaryotic cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148152A IL148152A (en) 1999-08-30 2002-02-14 DNA recombination with a unique sequence in eukaryotic cells

Country Status (19)

Country Link
US (2) US20030027337A1 (xx)
EP (2) EP1681355B1 (xx)
JP (1) JP2003520028A (xx)
KR (1) KR100490188B1 (xx)
CN (1) CN1182247C (xx)
AT (2) ATE331802T1 (xx)
AU (1) AU776297B2 (xx)
CA (1) CA2390526C (xx)
CY (2) CY1105288T1 (xx)
CZ (1) CZ302620B6 (xx)
DE (3) DE19941186A1 (xx)
DK (2) DK1214440T3 (xx)
ES (2) ES2334577T3 (xx)
HK (1) HK1047129B (xx)
IL (2) IL148152A0 (xx)
MX (1) MX244498B (xx)
PT (2) PT1214440E (xx)
SK (1) SK286034B6 (xx)
WO (1) WO2001016345A2 (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
CN100342008C (zh) * 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
CA2363924A1 (en) 1999-03-02 2000-09-08 Invitrogen Corporation Compositions and methods for use in recombinational cloning of nucleic acids
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP1390394A4 (en) * 2001-04-19 2004-05-26 Invitrogen Corp COMPOSITIONS AND METHODS FOR RECOMBINANT CLONING OF NUCLEIC ACID MOLECULES
WO2002095055A2 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
CA2441937A1 (en) * 2001-05-30 2002-12-05 Chromos Molecular Systems, Inc. Chromosome-based platforms
US20050287647A9 (en) * 2001-05-30 2005-12-29 Carl Perez Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes
US7351877B2 (en) 2002-03-29 2008-04-01 Syngenta Participations Ag Lambda integrase mediated recombination in plants
WO2004009768A2 (en) * 2002-07-18 2004-01-29 Invitrogen Corporation Viral vectors containing recombination sites
US7491539B2 (en) 2002-12-05 2009-02-17 Boehringer Ingelheim Pharma Kg Sequence specific DNA recombination in eukaryotic cells
TW200502390A (en) * 2002-11-28 2005-01-16 Peter Droege Sequence specific DNA recombination in eukaryotic cells
US20050095615A1 (en) * 2003-06-26 2005-05-05 Welch Peter J. Methods and compositions for detecting promoter activity and expressing fusion proteins
EP1687323A4 (en) 2003-08-08 2009-08-12 Life Technologies Corp METHODS AND COMPOSITIONS FOR DIRECT CLONING OF NUCLEIC ACID MOLECULES
DE602004027538D1 (de) * 2003-12-01 2010-07-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US7935862B2 (en) 2003-12-02 2011-05-03 Syngenta Participations Ag Targeted integration and stacking of DNA through homologous recombination
US8232456B2 (en) 2006-06-03 2012-07-31 Syngenta Participations Ag Corn event MIR162
US8404486B2 (en) 2007-11-30 2013-03-26 Boehringer Ingelheim International Gmbh Recombination sequences
CN102604936B (zh) * 2011-01-21 2013-09-04 上海市儿童医院 羊基因组中被噬菌体*c31整合酶识别的dna及其应用
EP2739738B1 (en) 2011-08-03 2018-06-20 Ramot at Tel Aviv University, Ltd. Use of integrase for targeted gene expression
CN102533741B (zh) * 2011-12-09 2014-09-24 深圳华大基因研究院 猪假attp位点及其用途
US11078493B2 (en) 2016-06-21 2021-08-03 Nanyang Technological University Site-specific DNA recombination
US11845954B2 (en) 2017-06-14 2023-12-19 Technische Universität Dresden Methods and means for genetic alteration of genomes utilizing designer DNA recombining enzymes
WO2023237453A1 (en) * 2022-06-07 2023-12-14 Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement Attp mv4-derived site-specific recombination and its use for integration of sequence of interest

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US7118911B1 (en) * 1990-03-05 2006-10-10 Genzyme Corporation DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator
US5227288A (en) * 1990-10-01 1993-07-13 Blattner Frederick R DNA sequencing vector with reversible insert
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5861273A (en) * 1993-12-21 1999-01-19 Celtrix Phamraceuticals, Inc. Chromosomal expression of heterologous genes in bacterial cells
FR2731014B1 (fr) * 1995-02-23 1997-03-28 Rhone Poulenc Rorer Sa Molecules d'adn, preparation et utilisation en therapie genique
PT937098E (pt) * 1995-06-07 2002-12-31 Invitrogen Corp Clonagem recombinatoria in vitro utilizando locais de recombinacao modificados
DE19530412A1 (de) * 1995-08-18 1997-02-20 Harald Von Prof Dr Melchner Selbst deletierende retrovirale Vektoren für die Gentherapie
FR2741892B1 (fr) * 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells
JP2001506132A (ja) * 1996-12-18 2001-05-15 ターゲティッド ジェネティクス コーポレイション Ａａｖベクターの産生における使用のためのリコンビナーゼ活性化可能ａａｖパッケージングカセット
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
CN100342008C (zh) * 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US6632672B2 (en) * 1998-08-19 2003-10-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for genomic modification

Also Published As

Publication number Publication date
ES2334577T3 (es) 2010-03-12
MXPA02002036A (es) 2003-08-20
HK1047129B (zh) 2006-10-20
AU7642900A (en) 2001-03-26
DE50013093D1 (de) 2006-08-10
CA2390526C (en) 2010-10-19
PT1214440E (pt) 2006-11-30
SK286034B6 (sk) 2008-01-07
US20130133092A1 (en) 2013-05-23
CN1387576A (zh) 2002-12-25
PT1681355E (pt) 2010-01-27
KR20020057953A (ko) 2002-07-12
DE19941186A1 (de) 2001-03-01
CN1182247C (zh) 2004-12-29
HK1047129A1 (en) 2003-02-07
ATE331802T1 (de) 2006-07-15
CY1105288T1 (el) 2010-03-03
DK1214440T3 (da) 2006-10-30
CA2390526A1 (en) 2001-03-08
AU776297B2 (en) 2004-09-02
WO2001016345A2 (de) 2001-03-08
WO2001016345A3 (de) 2001-12-06
CZ302620B6 (cs) 2011-08-03
IL148152A (en) 2007-10-31
EP1681355A1 (de) 2006-07-19
US20030027337A1 (en) 2003-02-06
MX244498B (es) 2007-03-28
JP2003520028A (ja) 2003-07-02
KR100490188B1 (ko) 2005-05-17
EP1681355B1 (de) 2009-10-21
SK3042002A3 (en) 2002-07-02
ES2267567T3 (es) 2007-03-16
DK1681355T3 (da) 2009-12-14
EP1214440A2 (de) 2002-06-19
EP1214440B1 (de) 2006-06-28
CY1110590T1 (el) 2015-04-29
CZ2002756A3 (cs) 2002-06-12
DE50015772D1 (de) 2009-12-03
ATE446373T1 (de) 2009-11-15

Similar Documents

Publication Publication Date Title
IL148152A0 (en) Sequence-specific dna recombination in eukaryotic cells
LTIP1826A (en) Process for preparing transformed prokaryotic host cell, stable gene amplification in the chromosome dna of prokaryotic microorganisms
EP0827410A4 (en) METHOD FOR INTRODUCING AND EXPRESSING GENES IN ANIMAL CELLS
EP0883344A4 (en) THERAPEUTIC MOLECULES OBTAINED BY TRANS-SPLITTING
IL180924A (en) Method for regulating cell proliferation and cell death
AUPN477695A0 (en) Gene therapy
AU716500B2 (en) Nucleic acid constructs for the cell cycle-regulated expression of genes, cells containing such constructs and their use for preparing drugs
MX9708854A (es) Terapia de genes para regulacion de celulas efectoras.
BR9806866A (pt) Cassete de expressão e uso do mesmo, cepa do cassete de expressão, vetor de ácido nucleico, cepa viral, composição farmacêutica, e, processos para estudar a função de um ou mais genes heterólogos em uma célula eucariótica, para produzir uma cepa de hsv, para tratamento do corpo humano ou animal e para realizar terapia genética em um humano ou animal, e, vacina.
GB9825096D0 (en) Cells,culture methods and their uses
DK0843731T3 (da) Adenovirusvektorer til genterapi
WO2001019966A3 (en) Isolation of muscle-derived stem cells and uses therefor
AU1502695A (en) Double stranded RNA correction of abherrant metabolic pathways associated with uncontrolled tumor cell and virus growth cycles
WO2004013313A3 (en) Antisense nucleic acids
NZ324157A (en) Conditionally replicating viral vectors and their use in treating HIV
HUP0202722A2 (hu) Szekvencia-specifikus DNS-rekombináció eukarióta sejtekben
EP0763205A4 (en) NUCLEIC ACID SEQUENCES REGULATING THE EXPRESSION OF LUNG SPECIFIC GENES
IL131436A0 (en) Compositions for treatment of disorders involving programmed cell death
AU4395599A (en) (-)-strand rna virus vector for nerve cell
DE50009932D1 (de) Gentransfer in humane lymphocyten mittels retroviraler scfv-zelltargeting vektoren
王宏伟 et al. Expression of human clotting factor IX with EBV shuttle vector
SETLOW Studies on bacterial spore ultraviolet light resistance and regulation of the activity of a spore protease(Final Report, 1 May 1990- 31 Oct. 1993)
NZ501962A (en) Vertebrate telomerase genes and proteins and uses thereof
BR9810643A (pt) Genes e proteìnas de telomerase de vertebrado, eutilização dos mesmos

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed