IL144583A0 - Chimeric protein kinase inhibitors - Google Patents

Chimeric protein kinase inhibitors

Info

Publication number
IL144583A0
IL144583A0 IL14458301A IL14458301A IL144583A0 IL 144583 A0 IL144583 A0 IL 144583A0 IL 14458301 A IL14458301 A IL 14458301A IL 14458301 A IL14458301 A IL 14458301A IL 144583 A0 IL144583 A0 IL 144583A0
Authority
IL
Israel
Prior art keywords
protein kinase
kinase inhibitors
chimeric protein
chimeric
inhibitors
Prior art date
Application number
IL14458301A
Other languages
English (en)
Original Assignee
Peptor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptor Ltd filed Critical Peptor Ltd
Priority to IL14458301A priority Critical patent/IL144583A0/xx
Publication of IL144583A0 publication Critical patent/IL144583A0/xx
Priority to NZ531120A priority patent/NZ531120A/en
Priority to EP02751604A priority patent/EP1416934A4/fr
Priority to JP2003515632A priority patent/JP2005501047A/ja
Priority to AU2002355204A priority patent/AU2002355204B2/en
Priority to CA002455602A priority patent/CA2455602A1/fr
Priority to PCT/IL2002/000618 priority patent/WO2003010281A2/fr
Priority to US10/764,288 priority patent/US7407939B2/en
Priority to US11/862,542 priority patent/US20080070843A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL14458301A 2001-07-26 2001-07-26 Chimeric protein kinase inhibitors IL144583A0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL14458301A IL144583A0 (en) 2001-07-26 2001-07-26 Chimeric protein kinase inhibitors
NZ531120A NZ531120A (en) 2001-07-26 2002-07-25 Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics
EP02751604A EP1416934A4 (fr) 2001-07-26 2002-07-25 Inhibiteurs de proteine kinase comprenant des mimetiques de atp conjugues a des peptides ou a des peptidomimetiques
JP2003515632A JP2005501047A (ja) 2001-07-26 2002-07-25 ペプチド又はペプチド模倣物質と結合したａｔｐ模倣物質を含むプロテインキナーゼ阻害剤
AU2002355204A AU2002355204B2 (en) 2001-07-26 2002-07-25 Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics
CA002455602A CA2455602A1 (fr) 2001-07-26 2002-07-25 Inhibiteurs de proteine kinase comprenant des mimetiques de atp conjugues a des peptides ou a des peptidomimetiques
PCT/IL2002/000618 WO2003010281A2 (fr) 2001-07-26 2002-07-25 Inhibiteurs de proteine kinase comprenant des mimetiques de atp conjugues a des peptides ou a des peptidomimetiques
US10/764,288 US7407939B2 (en) 2001-07-26 2004-01-23 Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics
US11/862,542 US20080070843A1 (en) 2001-07-26 2007-09-27 Protein kinase inhibitors comprising atp mimetics conjugated to peptides or peptidomimetics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL14458301A IL144583A0 (en) 2001-07-26 2001-07-26 Chimeric protein kinase inhibitors

Publications (1)

Publication Number Publication Date
IL144583A0 true IL144583A0 (en) 2002-05-23

Family

ID=11075649

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14458301A IL144583A0 (en) 2001-07-26 2001-07-26 Chimeric protein kinase inhibitors

Country Status (8)

Country Link
US (2) US7407939B2 (fr)
EP (1) EP1416934A4 (fr)
JP (1) JP2005501047A (fr)
AU (1) AU2002355204B2 (fr)
CA (1) CA2455602A1 (fr)
IL (1) IL144583A0 (fr)
NZ (1) NZ531120A (fr)
WO (1) WO2003010281A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144583A0 (en) 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
IL156429A0 (en) * 2003-06-12 2004-01-04 Peptor Ltd Cell permeable conjugates of peptides for inhibition of protein kinases
US20050004038A1 (en) * 2003-06-27 2005-01-06 Lyon Robert P. Bivalent inhibitors of Glutathione-S-Transferases
WO2006108270A1 (fr) 2005-04-11 2006-10-19 Pharmagap Inc. Inhibiteurs de proteines kinases et leurs utilisations
EP1922086A4 (fr) * 2005-08-05 2011-08-03 Pharmagap Inc Inhibiteurs de protéine kinase c ciblés et leurs utilisations
EE200600030A (et) * 2006-08-15 2008-04-15 Tartu �likool Proteiinkinaasi fluorestsents-sond
WO2008070823A2 (fr) 2006-12-07 2008-06-12 University Of South Florida Inhibiteur d'akt mimant le substrat
US8431529B2 (en) * 2007-07-31 2013-04-30 Sanford-Burnham Medical Research Institute Bi-dentate compounds as kinase inhibitors
BRPI0918970A2 (pt) * 2008-09-05 2019-09-24 Avila Therapeutics Inc algoritmo para projeto de inibidores irreversíveis
JP5364847B2 (ja) * 2009-09-03 2013-12-11 グラダリス インク． 組織特異的なペプチド模倣リガンドを用いる標的化送達
BR112012005962A8 (pt) * 2009-09-16 2018-01-02 Avila Therapeutics Inc Conjugados de proteína quinase, compostos e composição farmacêutica compreendendo os referidos compostos
WO2011082285A1 (fr) 2009-12-30 2011-07-07 Avila Therapeutics, Inc. Modification covalente de protéine, dirigée sur un ligand
US11162083B2 (en) 2018-06-14 2021-11-02 University Of South Carolina Peptide based inhibitors of Raf kinase protein dimerization and kinase activity
KR102152977B1 (ko) * 2018-08-29 2020-09-07 충남대학교 산학협력단 암 예방 또는 치료용 펩타이드 및 이를 포함하는 약학적 조성물
JP7385191B2 (ja) * 2019-08-30 2023-11-22 学校法人同志社 Ｅｍｌ４－ａｌｋ阻害ペプチドおよびこれを含む肺がん治療薬

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163904C (fr) 1993-05-28 2000-01-25 Craig A. Dionne Utilisation de derives de l'indolocarbazole pour traiter un etat pathologique de la prostate
US5594090A (en) 1994-04-06 1997-01-14 Nof Corporation Alkylene sulfide group-containing prepolymer, polymerizable composition and optical material
US5475110A (en) 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5591855A (en) 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5650407A (en) 1995-04-05 1997-07-22 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
WO1997022360A2 (fr) * 1995-12-20 1997-06-26 Medical Research Council Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques
US20020065221A1 (en) 1995-12-20 2002-05-30 Philip Cohen Control of protein synthesis, and screening method for agents
US20050053594A1 (en) 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
SE9600769D0 (sv) * 1996-02-28 1996-02-28 Astra Ab Compounds useful as analgesic
US7037891B2 (en) 1997-05-21 2006-05-02 Children's Medical Center Corporation Methods of modulating G-protein-coupled receptor kinase-associated signal transduction
US6174993B1 (en) 1997-05-21 2001-01-16 The Children's Medical Center Corp. Short peptides which selectively modulate the activity of serine/threonine kinases
WO1999008668A2 (fr) 1997-08-15 1999-02-25 Cephalon, Inc. Inhibiteur de tyrosine kinase combine a une castration chimique pour traiter un cancer de la prostate
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
AU4587901A (en) 2000-03-21 2001-10-03 Univ Johns Hopkins Bisubstrate inhibitors of kinases
IL152807A0 (en) * 2000-05-30 2003-06-24 Peptor Ltd Protein kinase inhibitors
US7034026B2 (en) 2001-04-10 2006-04-25 Merck & Co., Inc. Inhibitors of Akt activity
IL144583A0 (en) 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
CA2471385A1 (fr) 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Medicaments pour la prevention et le traitement du cancer
AU2003226301A1 (en) 2002-04-08 2003-10-20 Merck And Co., Inc. Method of treating cancer
AU2002364707A1 (en) 2002-04-23 2003-11-10 Duke University Atherosclerotic phenotype determinative genes and methods for using the same
IL156429A0 (en) 2003-06-12 2004-01-04 Peptor Ltd Cell permeable conjugates of peptides for inhibition of protein kinases

Also Published As

Publication number Publication date
WO2003010281A3 (fr) 2003-11-13
US20050026840A1 (en) 2005-02-03
US7407939B2 (en) 2008-08-05
EP1416934A4 (fr) 2005-11-02
CA2455602A1 (fr) 2003-02-06
AU2002355204B8 (en) 2003-02-17
JP2005501047A (ja) 2005-01-13
US20080070843A1 (en) 2008-03-20
WO2003010281A2 (fr) 2003-02-06
NZ531120A (en) 2008-03-28
AU2002355204B2 (en) 2007-08-16
EP1416934A2 (fr) 2004-05-12

Similar Documents

Publication Publication Date Title
HUP0400300A2 (en) Pyrrolopyrimidines as protein kinase inhibitors
HK1068134A1 (en) Pyrrolopyrimidines as protein kinase inhibitors
HK1062433A1 (en) Pyrazole compounds useful as protein kinase inhibitors
HK1057748A1 (en) Pyrazole compounds useful as protein kinase inhibitors
IL161516A0 (en) Benzimidazoles useful as protein kinase inhibitors
IL144583A0 (en) Chimeric protein kinase inhibitors
SI1318997T1 (sl) Pirazolne spojine, uporabne kot inhibitorji protein-kinaze
IL145329A0 (en) Protein tyrosine kinase inhibitors
IL151779A0 (en) Protein tyrosine kinase inhibitors
SI1345922T1 (sl) Pirazolne spojine, koristne kot inhibitorji protein kinaze
AU2002355906A1 (en) Thiopyrane-4-ones as dna protein kinase inhibitors