IL142133A0 - Methods for identifying multiple primary targets of a drug - Google Patents

Methods for identifying multiple primary targets of a drug

Info

Publication number
IL142133A0
IL142133A0 IL14213399A IL14213399A IL142133A0 IL 142133 A0 IL142133 A0 IL 142133A0 IL 14213399 A IL14213399 A IL 14213399A IL 14213399 A IL14213399 A IL 14213399A IL 142133 A0 IL142133 A0 IL 142133A0
Authority
IL
Israel
Prior art keywords
drug
methods
multiple primary
identifying multiple
primary targets
Prior art date
Application number
IL14213399A
Other languages
English (en)
Original Assignee
Rosetta Inpharmatics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics Inc filed Critical Rosetta Inpharmatics Inc
Publication of IL142133A0 publication Critical patent/IL142133A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL14213399A 1998-09-23 1999-09-22 Methods for identifying multiple primary targets of a drug IL142133A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/159,352 US6146830A (en) 1998-09-23 1998-09-23 Method for determining the presence of a number of primary targets of a drug
PCT/US1999/022061 WO2000017402A1 (fr) 1998-09-23 1999-09-22 Methodes d'identification de plusieurs cibles primaires d'un medicament

Publications (1)

Publication Number Publication Date
IL142133A0 true IL142133A0 (en) 2002-03-10

Family

ID=22572224

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14213399A IL142133A0 (en) 1998-09-23 1999-09-22 Methods for identifying multiple primary targets of a drug

Country Status (9)

Country Link
US (3) US6146830A (fr)
EP (1) EP1115884A1 (fr)
JP (1) JP2002526757A (fr)
KR (1) KR20010085834A (fr)
CN (1) CN1328603A (fr)
AU (1) AU755518B2 (fr)
CA (1) CA2344267A1 (fr)
IL (1) IL142133A0 (fr)
WO (1) WO2000017402A1 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402089D0 (sv) * 1994-06-14 1994-06-14 Rudolf Valenta Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6876760B1 (en) 2000-12-04 2005-04-05 Cytokinetics, Inc. Classifying cells based on information contained in cell images
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US7151847B2 (en) * 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US7371516B1 (en) 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US7013221B1 (en) 1999-07-16 2006-03-14 Rosetta Inpharmatics Llc Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
CA2743462C (fr) * 1999-07-30 2012-10-16 Basantkumar John Oommen Methode de generation de cartes de cardinalite d'attributs
US6941323B1 (en) 1999-08-09 2005-09-06 Almen Laboratories, Inc. System and method for image comparison and retrieval by enhancing, defining, and parameterizing objects in images
WO2001053534A2 (fr) * 2000-01-21 2001-07-26 Curagen Corporation Procede d'identification de la fonction d'un agent d'essai
WO2001067103A1 (fr) 2000-03-06 2001-09-13 Bioseek, Inc. Criblage d'homologie de fonctions
US7266458B2 (en) * 2000-03-06 2007-09-04 Bioseek, Inc. BioMAP analysis
US6763307B2 (en) * 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
DE10013990C2 (de) * 2000-03-22 2003-12-04 Invitek Biotechnik & Biodesign Polyfunktionelles Trägermaterial für die komplexe Nukleinsäureanalytik
KR20040010041A (ko) 2000-05-04 2004-01-31 예일 유니버시티 단백질 활성의 스크리닝을 위한 고밀도 단백질 어레이
JP3658278B2 (ja) * 2000-05-16 2005-06-08 キヤノン株式会社 固体撮像装置およびそれを用いた固体撮像システム
EP1322788A2 (fr) * 2000-06-23 2003-07-02 Cytokinetics, Inc. Analyse d'image pour phenotyper des ensembles de cellules mutantes
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
CA2422021A1 (fr) * 2000-09-12 2003-03-11 Institute Of Medicinal Molecular Design, Inc. Procede de formation d'un reseau a fonction moleculaire
US7218764B2 (en) * 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6599694B2 (en) * 2000-12-18 2003-07-29 Cytokinetics, Inc. Method of characterizing potential therapeutics by determining cell-cell interactions
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) * 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US20050182242A1 (en) * 2001-05-11 2005-08-18 Michael Snyder Global analysis of protein activities using proteome chips
US20030014232A1 (en) * 2001-05-22 2003-01-16 Paterson Thomas S. Methods for predicting biological activities of cellular constituents
US20020194201A1 (en) * 2001-06-05 2002-12-19 Wilbanks John Thompson Systems, methods and computer program products for integrating biological/chemical databases to create an ontology network
US20020194154A1 (en) * 2001-06-05 2002-12-19 Levy Joshua Lerner Systems, methods and computer program products for integrating biological/chemical databases using aliases
AU2002312411A1 (en) * 2001-06-07 2002-12-16 Proligo Llc Microcalorimetric detection of analytes and binding events
US20030104426A1 (en) * 2001-06-18 2003-06-05 Linsley Peter S. Signature genes in chronic myelogenous leukemia
US7031846B2 (en) 2001-08-16 2006-04-18 Affymetrix, Inc. Method, system, and computer software for the presentation and storage of analysis results
CA2455181C (fr) * 2001-08-01 2010-04-06 Merck & Co., Inc. Derives de la benzimidazo[4,5-f]isoquinolinone
GB0118995D0 (en) * 2001-08-03 2001-09-26 Univ Wales Medicine Detection of mutations in nucleic acids
US20040071328A1 (en) * 2001-09-07 2004-04-15 Vaisberg Eugeni A. Classifying cells based on information contained in cell images
US20040023295A1 (en) * 2001-11-21 2004-02-05 Carol Hamilton Methods and systems for analyzing complex biological systems
US20060100903A1 (en) * 2002-03-22 2006-05-11 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Method of enhancing the efficiency of a pharmaceutical business
US20030180710A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
US20030228566A1 (en) * 2002-06-11 2003-12-11 Biotechplex Corporation Method of and apparatus for screening for drug candidates
US20040253642A1 (en) * 2003-06-06 2004-12-16 Grant Zimmermann System and method for multidimensional evaluation of combinations of compositions
US7235353B2 (en) * 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7246012B2 (en) * 2003-07-18 2007-07-17 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
US7660709B2 (en) * 2004-03-18 2010-02-09 Van Andel Research Institute Bioinformatics research and analysis system and methods associated therewith
US20050273271A1 (en) * 2004-04-05 2005-12-08 Aibing Rao Method of characterizing cell shape
US20070031818A1 (en) * 2004-07-15 2007-02-08 Cytokinetics, Inc., A Delaware Corporation Assay for distinguishing live and dead cells
US7323318B2 (en) * 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
JP4214124B2 (ja) * 2005-03-14 2009-01-28 株式会社バイオエコーネット 耳式体温計
WO2008018905A2 (fr) * 2006-01-17 2008-02-14 Cellumen, Inc. Procédé permettant de prédire les réponses des systèmes biologiques
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
EP2095119A2 (fr) * 2006-11-10 2009-09-02 Cellumen, Inc. Biocapteurs d'interaction proteine-proteine et leurs procedes d'utilisation
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
JP5487298B2 (ja) * 2009-06-11 2014-05-07 株式会社東芝 ３次元画像生成
AU2012229102B2 (en) 2011-03-17 2016-02-04 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
CN104965998B (zh) * 2015-05-29 2017-09-15 华中农业大学 多靶标药物和/或药物组合的筛选方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CZ291877B6 (cs) * 1991-09-24 2003-06-18 Keygene N.V. Způsob amplifikace přinejmenším jednoho restrikčního fragmentu z výchozí DNA a způsob přípravy sestavy amplifikovaných restrikčních fragmentů
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
EP0761410B1 (fr) 1995-09-11 2002-07-17 Vervant Limited Appareil de mélange
US6165709A (en) * 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6132969A (en) 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models

Also Published As

Publication number Publication date
CN1328603A (zh) 2001-12-26
KR20010085834A (ko) 2001-09-07
US6300078B1 (en) 2001-10-09
WO2000017402A1 (fr) 2000-03-30
EP1115884A1 (fr) 2001-07-18
CA2344267A1 (fr) 2000-03-30
AU755518B2 (en) 2002-12-12
US6303291B1 (en) 2001-10-16
JP2002526757A (ja) 2002-08-20
AU6159599A (en) 2000-04-10
US6146830A (en) 2000-11-14

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