IL140592A0 - Synthetic peptides and methods of use for autoimmune disease therapies - Google Patents

Synthetic peptides and methods of use for autoimmune disease therapies

Info

Publication number
IL140592A0
IL140592A0 IL14059299A IL14059299A IL140592A0 IL 140592 A0 IL140592 A0 IL 140592A0 IL 14059299 A IL14059299 A IL 14059299A IL 14059299 A IL14059299 A IL 14059299A IL 140592 A0 IL140592 A0 IL 140592A0
Authority
IL
Israel
Prior art keywords
methods
autoimmune disease
synthetic peptides
disease therapies
therapies
Prior art date
Application number
IL14059299A
Other languages
English (en)
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of IL140592A0 publication Critical patent/IL140592A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
IL14059299A 1998-07-23 1999-07-22 Synthetic peptides and methods of use for autoimmune disease therapies IL140592A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9385998P 1998-07-23 1998-07-23
US12367599P 1999-03-09 1999-03-09
PCT/US1999/016617 WO2000005249A2 (fr) 1998-07-23 1999-07-22 Peptides synthetiques et procedes d'utilisation de ceux-ci dans des therapies de maladies auto-immunes

Publications (1)

Publication Number Publication Date
IL140592A0 true IL140592A0 (en) 2002-02-10

Family

ID=26787981

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14059299A IL140592A0 (en) 1998-07-23 1999-07-22 Synthetic peptides and methods of use for autoimmune disease therapies

Country Status (8)

Country Link
US (2) US7566767B2 (fr)
EP (3) EP1105414A2 (fr)
JP (1) JP2003521448A (fr)
AU (1) AU766498B2 (fr)
CA (1) CA2336238A1 (fr)
IL (1) IL140592A0 (fr)
WO (1) WO2000005249A2 (fr)
ZA (1) ZA200100366B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
AU766498B2 (en) * 1998-07-23 2003-10-16 President And Fellows Of Harvard College, The Synthetic peptides and methods of use for autoimmune disease therapies
CA2337688C (fr) 1998-07-23 2016-04-05 Yeda Research And Development Co., Ltd. Traitement de maladies auto-immunes a l'aide du copolymere 1 et copolymeres associes
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
WO2005046719A1 (fr) 2003-11-12 2005-05-26 Yeda Research And Development Co. Ltd. Vaccin et procede pour traiter des maladies neurodegeneratives
US7022663B2 (en) 2000-02-18 2006-04-04 Yeda Research And Development Co., Ltd. Oral, nasal and pulmonary dosage formulations of copolymer 1
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (fr) 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Traitement de maladies du systeme nerveux central au moyen d'anticorps diriges contre l'acetate de glatiramere
AU2002362445B2 (en) 2001-10-03 2006-09-21 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use
ES2349033T3 (es) 2001-12-04 2010-12-22 Teva Pharmaceutical Industries, Ltd. Procedimientos para la medida de la actividad del acetato de glatiramer.
MXPA04005537A (es) 2001-12-06 2004-11-01 Yeda Res & Dev Vacuna y metodo para el tratamiento de enfermedades de las neuronas motoras.
DE60320196T2 (de) * 2002-10-02 2009-05-14 F. Hoffmann-La Roche Ag Verfahren zur Identifizierung antigener Peptide
NZ569331A (en) * 2003-01-21 2010-08-27 Yeda Res & Dev COP 1 for treatment of inflammatory bowel diseases
CA2548310C (fr) 2003-12-09 2014-02-18 Yeda Research And Development Co. Ltd. Methode et vaccin comprenant le copolymere 1 pour le traitement de troubles psychiatriques
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
BRPI0510738A (pt) 2004-05-07 2007-11-20 Peptimmune Inc métodos de tratar doenças com copolìmeros aleatórios
SI1797109T1 (sl) * 2004-09-09 2016-07-29 Yeda Research And Development Co., Ltd. Zmesi polipeptidov, sestavki, ki jih vsebujejo, in postopki za njihovo pripravo ter njihove uporabe
US20070264229A1 (en) * 2004-09-13 2007-11-15 Strominger Jack L Peptides for Treatment of Autoimmune Disease
EP1853287A2 (fr) * 2005-02-02 2007-11-14 Yeda Research And Development Co., Ltd. Copolymeres peptidiques synthetiques pour le traitement et la prevention de troubles cardiovasculaires
AU2007238595A1 (en) 2006-04-13 2007-10-25 Peptimmune, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
WO2008001380A2 (fr) 2006-06-28 2008-01-03 Yeda Research And Development Co. Ltd. Méthode de traitement de la dégénérescence maculaire liée à l'âge
WO2009018477A2 (fr) * 2007-07-31 2009-02-05 Cognosci, Inc. Procédés d'inhibition de la calcineurine avec des analogues d'apoe
BRPI0817682A2 (pt) 2007-10-16 2015-04-07 Peptimmune Inc Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos
CA2760802C (fr) 2009-08-20 2016-01-12 Ety Klinger Therapie a l'acetate de glatiramere a basse frequence
JP2013511725A (ja) * 2009-11-17 2013-04-04 アレス トレーディング ソシエテ アノニム 血清タンパク質に基づくランダム配列ポリマー組成物の検出による、ランダム配列ポリマー組成物の設計、生物学的利用性、及び有効性を改良するための方法
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
NZ703122A (en) 2010-10-11 2016-06-24 Teva Pharma Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
EP2667888A4 (fr) * 2011-01-28 2015-11-11 Univ Oregon Health & Science Ligands des lymphocytes t recombinés et anticorps se liant aux lymphocytes b destinés au traitement de maladies autoimmunes
WO2013055683A1 (fr) 2011-10-10 2013-04-18 Teva Pharmaceutical Industries Ltd. Polymorphismes de nucléotide simple utiles pour prédire une réponse clinique à l'acétate de glatiramère
US9617596B2 (en) 2012-10-10 2017-04-11 Teva Pharmaceutical Industries, Ltd. Biomarkers predictive for clinical response for glatiramer acetate
UY35790A (es) 2013-10-21 2015-05-29 Teva Pharma Marcadores genéticos que predicen la respuesta al acetato de glatiramer
AU2015228372B2 (en) 2014-03-12 2018-05-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
JP2017525370A (ja) 2014-08-21 2017-09-07 ザ ジェネラル ホスピタル コーポレイション 腫瘍壊死因子スーパーファミリーおよびｔｎｆ様リガンドムテインならびに腫瘍壊死因子スーパーファミリーおよびｔｎｆ様リガンドムテインを調製および使用する方法
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
CA3050086A1 (fr) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Systemes de depot de glatiramere pour le traitement de formes progressives de sclerose en plaques
WO2019175869A1 (fr) 2018-03-12 2019-09-19 Yeda Research And Development Co. Ltd Traitement d'une maladie cardiaque

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US6066621A (en) 1989-12-10 2000-05-23 Yeda Research And Development Co. Ltd. Synthetic peptides for the treatment of myasthenia gravis
WO1992002543A1 (fr) * 1990-08-01 1992-02-20 Cytel Corporation Nouveaux peptides immunosuppresseurs
US5679640A (en) * 1991-02-12 1997-10-21 Cytel Corporation Immunosuppressant peptides
US5583031A (en) 1992-02-06 1996-12-10 President And Fellows Of Harvard College Empty major histocompatibility class II heterodimers
WO1994000148A1 (fr) 1992-06-18 1994-01-06 Yeda Research And Development Co. Ltd. Peptides synthetiques pour le traitement de la myasthenie grave
US6696061B1 (en) 1992-08-11 2004-02-24 President And Fellows Of Harvard College Immunomodulatory peptides
AU6916694A (en) * 1993-05-19 1994-12-12 Cytel Corporation Novel treatments for allergic diseases
US5576419A (en) * 1993-06-30 1996-11-19 Regents Of The University Of Minnesota Mild solid-phase synthesis of aligned branched triple-helical peptides
AU698962B2 (en) 1993-09-14 1998-11-12 Epimmune, Inc. Alteration of immune response using pan DR-binding peptides
WO1995026980A2 (fr) * 1994-04-01 1995-10-12 Immulogic Pharmaceutical Corporation Peptides haptines et leurs utilisations
AU7242994A (en) * 1994-05-20 1995-12-18 United States Of America, As Represented By The Secretary Of The Army, The Model for testing immunogenicity of peptides
US5800808A (en) 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
WO1997049430A1 (fr) 1996-06-26 1997-12-31 Antigen Express, Inc. Immunotherapie par modulation de la presentation d'antigenes
WO1998005684A2 (fr) 1996-08-05 1998-02-12 President And Fellows Of Havard College Oligomeres peptidiques de liaison cmh et procedes d'utilisation
IL119989A0 (en) * 1997-01-10 1997-04-15 Yeda Res & Dev Pharmaceutical compositions for oral treatment of multiple sclerosis
CA2337688C (fr) 1998-07-23 2016-04-05 Yeda Research And Development Co., Ltd. Traitement de maladies auto-immunes a l'aide du copolymere 1 et copolymeres associes
AU766498B2 (en) * 1998-07-23 2003-10-16 President And Fellows Of Harvard College, The Synthetic peptides and methods of use for autoimmune disease therapies
US6514938B1 (en) * 1998-09-25 2003-02-04 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6800287B2 (en) * 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6844314B2 (en) * 2000-01-20 2005-01-18 Yeda Research Development Co., Ltd. Use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy
AU2002362445B2 (en) * 2001-10-03 2006-09-21 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use
US20060276390A1 (en) * 2003-07-31 2006-12-07 Yeda Research And Development Co. Ltd. Combined treatments comprising synthetic peptide copolymers for preventing graft rejection

Also Published As

Publication number Publication date
WO2000005249A3 (fr) 2000-10-05
EP2327712B1 (fr) 2014-10-15
ZA200100366B (en) 2002-01-14
EP1105414A2 (fr) 2001-06-13
EP2327712A3 (fr) 2011-09-14
AU766498B2 (en) 2003-10-16
US20080207526A1 (en) 2008-08-28
JP2003521448A (ja) 2003-07-15
CA2336238A1 (fr) 2000-02-03
EP2327712A2 (fr) 2011-06-01
WO2000005249A2 (fr) 2000-02-03
US20040006022A1 (en) 2004-01-08
US9066905B2 (en) 2015-06-30
EP2848627A3 (fr) 2015-04-01
EP2848627A2 (fr) 2015-03-18
AU5223499A (en) 2000-02-14
US7566767B2 (en) 2009-07-28

Similar Documents

Publication Publication Date Title
IL140592A0 (en) Synthetic peptides and methods of use for autoimmune disease therapies
HUP0103321A3 (en) Peptide antagonists of zonulin and methods for use of the same
EP0880356A4 (fr) Peptides antimicrobiens et procedes d'utilisation associes
EP0785276A4 (fr) Modification d'un peptide et d'une proteine
HK1096974A1 (en) Antibody against human parathormone related peptides
ZA969444B (en) Peptides which enhance transport across tissues and methods of identifying and using the same
EP1037911A4 (fr) Systeme anti-pathogene et procedes d'utilisation
IL112903A0 (en) GnRH antagonist peptides
EP1071706A4 (fr) Proteines de fusion gfp a degradation rapide et methodes d'utilisation
HUP9903378A3 (en) Autoantigen and proteins structurally related thereto for use in immunotherapy of autoimmune diseases
EP0831793A4 (fr) Particules proteiques a usage therapeutique et diagnostique
HUP9900147A3 (en) Therapeutic agents and autoimmune diseases
IL129024A0 (en) Use of proteins as agent against autoimmune diseases
IL131929A0 (en) Rap protein its preparation and use
HUP9801680A3 (en) Peptides and remedy for autoimmune diseases comprising the same
AU1087797A (en) Clip analogues and autoimmune disease
GB9918155D0 (en) Proteins and peptides
EP1046036A4 (fr) Procedes d'obtention de sondes de fonction de peptides
GB9621825D0 (en) Microparticles and their use as therapeutic vehicles
IL120759A0 (en) Modulators of the function of fas receptors and other proteins
AU4705201A (en) Peptide constructs for treating autoimmune and related diseases
AU3964499A (en) Agouti-related protein analogs and methods of use
EP1119251A4 (fr) Procedes de detection d'agents regulant l'apoptose destines a la therapie anabolisante osseuse et utilisations de tels agents
GB9714276D0 (en) Peptides and related compounds
IL116658A0 (en) Peptides their preparation and use