IL136592A - (E)-3-[1-N-n-BUTYL-5-[2-(2-CARBOXYPHENYL) METHOXY-4-CHLOROPHENYL]-1H-PYRAZOL-4-YL]-2-[(5-METHOXY-2,3-DIHYDROBENZOFURAN-6- YL) METHYL]-PROP-2-ENOIC ACID MONOARGININYL SALT AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF - Google Patents
(E)-3-[1-N-n-BUTYL-5-[2-(2-CARBOXYPHENYL) METHOXY-4-CHLOROPHENYL]-1H-PYRAZOL-4-YL]-2-[(5-METHOXY-2,3-DIHYDROBENZOFURAN-6- YL) METHYL]-PROP-2-ENOIC ACID MONOARGININYL SALT AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOFInfo
- Publication number
- IL136592A IL136592A IL13659298A IL13659298A IL136592A IL 136592 A IL136592 A IL 136592A IL 13659298 A IL13659298 A IL 13659298A IL 13659298 A IL13659298 A IL 13659298A IL 136592 A IL136592 A IL 136592A
- Authority
- IL
- Israel
- Prior art keywords
- methoxy
- dihydrobenzofuran
- carboxyphenyl
- pyrazol
- chlorophenyl
- Prior art date
Links
- QVEGXHOZQYEMHS-BUVRLJJBSA-N 2-[[2-[2-butyl-4-[(e)-2-carboxy-3-(5-methoxy-2,3-dihydro-1-benzofuran-6-yl)prop-1-enyl]pyrazol-3-yl]-5-chlorophenoxy]methyl]benzoic acid Chemical compound CCCCN1N=CC(\C=C(/CC=2C(=CC=3CCOC=3C=2)OC)C(O)=O)=C1C1=CC=C(Cl)C=C1OCC1=CC=CC=C1C(O)=O QVEGXHOZQYEMHS-BUVRLJJBSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6773297P | 1997-12-08 | 1997-12-08 | |
| PCT/US1998/025903 WO1999029685A1 (en) | 1997-12-08 | 1998-12-07 | (e)-3-[1-n-butyl- 5-[2-(2-carboxyphenyl)methoxy- 4-chlorophenyl]-1h- pyrazol-4-yl]-2-[(5- methoxy-2,3- dihydrobenzofuran-6-yl)methyl]- prop-2-enoic acid monoargininyl salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL136592A0 IL136592A0 (en) | 2001-06-14 |
| IL136592A true IL136592A (en) | 2003-03-12 |
Family
ID=22078027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13659298A IL136592A (en) | 1997-12-08 | 1998-12-07 | (E)-3-[1-N-n-BUTYL-5-[2-(2-CARBOXYPHENYL) METHOXY-4-CHLOROPHENYL]-1H-PYRAZOL-4-YL]-2-[(5-METHOXY-2,3-DIHYDROBENZOFURAN-6- YL) METHYL]-PROP-2-ENOIC ACID MONOARGININYL SALT AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6300359B1 (no) |
| EP (1) | EP1037888B1 (no) |
| JP (1) | JP2001525405A (no) |
| KR (1) | KR20010040292A (no) |
| CN (1) | CN1281447A (no) |
| AR (1) | AR017426A1 (no) |
| AT (1) | ATE223404T1 (no) |
| AU (1) | AU747108B2 (no) |
| BR (1) | BR9813409A (no) |
| CA (1) | CA2312965A1 (no) |
| CO (1) | CO5021171A1 (no) |
| DE (1) | DE69807745T2 (no) |
| DK (1) | DK1037888T3 (no) |
| ES (1) | ES2182383T3 (no) |
| HU (1) | HUP0100423A3 (no) |
| IL (1) | IL136592A (no) |
| NO (1) | NO20002904D0 (no) |
| NZ (1) | NZ504898A (no) |
| PL (1) | PL341601A1 (no) |
| PT (1) | PT1037888E (no) |
| TR (1) | TR200001633T2 (no) |
| TW (1) | TW505643B (no) |
| WO (1) | WO1999029685A1 (no) |
| ZA (1) | ZA9811154B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2235854T3 (es) * | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
| US20050026859A1 (en) * | 2002-11-12 | 2005-02-03 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| WO2007031933A2 (en) | 2005-09-12 | 2007-03-22 | Actelion Pharmaceuticals Ltd | Stable pharmaceutical composition comprising a pyrimidine-sulfamide |
| WO2007067779A2 (en) * | 2005-12-08 | 2007-06-14 | Tsrl, Inc. | Methods and compositions for drug delivery enhancement |
| WO2009061805A1 (en) * | 2007-11-05 | 2009-05-14 | Scolr Pharma, Inc. | Formulations for enhanced bioavailability of orally administered polar agents |
| US8805519B2 (en) | 2010-09-30 | 2014-08-12 | Nevro Corporation | Systems and methods for detecting intrathecal penetration |
| US10980999B2 (en) | 2017-03-09 | 2021-04-20 | Nevro Corp. | Paddle leads and delivery tools, and associated systems and methods |
| WO2019191423A1 (en) | 2018-03-29 | 2019-10-03 | Nevro Corp. | Leads having sidewall openings, and associated systems and methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| MX9800975A (es) * | 1995-08-02 | 1998-04-30 | Smithkline Beecham Corp | Antagonistas de receptor de endotelina. |
-
1998
- 1998-12-04 AR ARP980106187A patent/AR017426A1/es not_active Application Discontinuation
- 1998-12-04 CO CO98072345A patent/CO5021171A1/es unknown
- 1998-12-07 BR BR9813409-4A patent/BR9813409A/pt not_active Application Discontinuation
- 1998-12-07 PL PL98341601A patent/PL341601A1/xx unknown
- 1998-12-07 AT AT98961951T patent/ATE223404T1/de not_active IP Right Cessation
- 1998-12-07 PT PT98961951T patent/PT1037888E/pt unknown
- 1998-12-07 DE DE69807745T patent/DE69807745T2/de not_active Expired - Fee Related
- 1998-12-07 JP JP2000524279A patent/JP2001525405A/ja not_active Withdrawn
- 1998-12-07 NZ NZ504898A patent/NZ504898A/xx unknown
- 1998-12-07 IL IL13659298A patent/IL136592A/xx not_active IP Right Cessation
- 1998-12-07 KR KR1020007006162A patent/KR20010040292A/ko not_active Withdrawn
- 1998-12-07 ES ES98961951T patent/ES2182383T3/es not_active Expired - Lifetime
- 1998-12-07 CA CA002312965A patent/CA2312965A1/en not_active Abandoned
- 1998-12-07 AU AU17138/99A patent/AU747108B2/en not_active Ceased
- 1998-12-07 CN CN98811945A patent/CN1281447A/zh active Pending
- 1998-12-07 EP EP98961951A patent/EP1037888B1/en not_active Expired - Lifetime
- 1998-12-07 DK DK98961951T patent/DK1037888T3/da active
- 1998-12-07 US US09/581,066 patent/US6300359B1/en not_active Expired - Fee Related
- 1998-12-07 HU HU0100423A patent/HUP0100423A3/hu unknown
- 1998-12-07 TR TR2000/01633T patent/TR200001633T2/xx unknown
- 1998-12-07 ZA ZA9811154A patent/ZA9811154B/xx unknown
- 1998-12-07 WO PCT/US1998/025903 patent/WO1999029685A1/en not_active Ceased
-
1999
- 1999-01-20 TW TW087120292A patent/TW505643B/zh active
-
2000
- 2000-06-07 NO NO20002904A patent/NO20002904D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20002904L (no) | 2000-06-07 |
| TR200001633T2 (tr) | 2001-07-23 |
| HK1032229A1 (en) | 2001-07-13 |
| EP1037888B1 (en) | 2002-09-04 |
| PT1037888E (pt) | 2002-12-31 |
| CN1281447A (zh) | 2001-01-24 |
| AR017426A1 (es) | 2001-09-05 |
| TW505643B (en) | 2002-10-11 |
| NO20002904D0 (no) | 2000-06-07 |
| ATE223404T1 (de) | 2002-09-15 |
| DE69807745T2 (de) | 2003-05-15 |
| ES2182383T3 (es) | 2003-03-01 |
| CO5021171A1 (es) | 2001-03-27 |
| AU1713899A (en) | 1999-06-28 |
| PL341601A1 (en) | 2001-04-23 |
| ZA9811154B (en) | 1999-06-08 |
| HUP0100423A2 (hu) | 2002-05-29 |
| HUP0100423A3 (en) | 2002-08-28 |
| IL136592A0 (en) | 2001-06-14 |
| JP2001525405A (ja) | 2001-12-11 |
| US6300359B1 (en) | 2001-10-09 |
| DK1037888T3 (da) | 2003-01-06 |
| BR9813409A (pt) | 2000-10-10 |
| NZ504898A (en) | 2002-11-26 |
| KR20010040292A (ko) | 2001-05-15 |
| WO1999029685A1 (en) | 1999-06-17 |
| EP1037888A4 (en) | 2001-08-22 |
| CA2312965A1 (en) | 1999-06-17 |
| AU747108B2 (en) | 2002-05-09 |
| EP1037888A1 (en) | 2000-09-27 |
| DE69807745D1 (de) | 2002-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |