IL134042A0 - Modified dorsal tissue affecting factor and compositions - Google Patents

Modified dorsal tissue affecting factor and compositions

Info

Publication number
IL134042A0
IL134042A0 IL13404298A IL13404298A IL134042A0 IL 134042 A0 IL134042 A0 IL 134042A0 IL 13404298 A IL13404298 A IL 13404298A IL 13404298 A IL13404298 A IL 13404298A IL 134042 A0 IL134042 A0 IL 134042A0
Authority
IL
Israel
Prior art keywords
compositions
affecting factor
tissue affecting
dorsal tissue
modified
Prior art date
Application number
IL13404298A
Other languages
English (en)
Original Assignee
Regeneron Pharma
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Univ California filed Critical Regeneron Pharma
Publication of IL134042A0 publication Critical patent/IL134042A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL13404298A 1997-07-17 1998-07-17 Modified dorsal tissue affecting factor and compositions IL134042A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/897,236 US6075007A (en) 1997-07-17 1997-07-17 Modified noggin polypeptide and compositions
PCT/US1998/014603 WO1999003996A1 (fr) 1997-07-17 1998-07-17 Facteur modifie affectant le tissu dorsal et composition a base de ce facteur

Publications (1)

Publication Number Publication Date
IL134042A0 true IL134042A0 (en) 2001-04-30

Family

ID=25407592

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13404298A IL134042A0 (en) 1997-07-17 1998-07-17 Modified dorsal tissue affecting factor and compositions
IL134042A IL134042A (en) 1997-07-17 2000-01-13 Modified dorsal tissue affecting factor and compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL134042A IL134042A (en) 1997-07-17 2000-01-13 Modified dorsal tissue affecting factor and compositions

Country Status (10)

Country Link
US (3) US6075007A (fr)
EP (1) EP1003860B1 (fr)
JP (1) JP4181300B2 (fr)
AT (1) ATE252639T1 (fr)
AU (1) AU735851B2 (fr)
CA (1) CA2296769C (fr)
DE (1) DE69819167T2 (fr)
HK (1) HK1026229A1 (fr)
IL (2) IL134042A0 (fr)
WO (1) WO1999003996A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011163A1 (fr) 1998-08-20 2000-03-02 Regeneron Pharmaceuticals, Inc. Dcr5, proteine de fixation de proteines morphogenetiques osseuses, et ses applications
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1133558B2 (fr) 1998-11-27 2016-04-13 UCB Pharma S.A. Compositions et methodes d'augmentation de la mineralisation de la substance osseuse
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
AU2002243495A1 (en) * 2001-01-12 2002-07-24 University Of Medicine And Dentistry Of New Jersey Bone morphogenetic protein-2 in the treatment and diagnosis of cancer
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20030134790A1 (en) * 2002-01-11 2003-07-17 University Of Medicine And Dentistry Of New Jersey Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
US7576065B2 (en) * 2002-02-15 2009-08-18 Cornell Research Foundation, Inc. Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
WO2003087763A2 (fr) 2002-04-03 2003-10-23 Celltech R & D, Inc. Association de polymorphismes dans la region du gene sost avec la densite minerale de l'os
PT1608399E (pt) * 2003-03-14 2012-04-13 Ucb Mfg Inc Complexo de esclerostina e noguina ou cordina, e agentes que modulam a formação do referido complexo
ES2586401T3 (es) 2003-06-16 2016-10-14 Ucb Pharma S.A. Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea
DK2341147T3 (da) * 2004-07-09 2019-11-11 Viacyte Inc Præprimitive stribe- og mesendodermceller
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
WO2007028212A1 (fr) * 2005-09-08 2007-03-15 Apollo Life Sciences Limited Noggine et molécules chimères de celle-ci
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
KR101163171B1 (ko) * 2009-01-20 2012-07-19 (주)케어젠 노긴?유래 펩타이드 및 그의 용도
EP2421957B1 (fr) 2009-04-22 2020-11-18 Viacyte, Inc. Compositions cellulaires issues de cellules reprogrammées dédifférenciées
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
PT3195880T (pt) 2010-05-14 2020-02-21 Amgen Inc Formulações de anticorpos antiesclerostina de concentração elevada
EP2662385A4 (fr) * 2011-01-07 2015-11-11 Chugai Pharmaceutical Co Ltd Procédé pour l'amélioration de propriétés physiques d'anticorps
MX2013010011A (es) 2011-03-01 2014-10-24 Amgen Inc Agentes de unión biespecífica.
KR20140018315A (ko) 2011-03-25 2014-02-12 암젠 인크 항스클러로스틴 항체 결정 및 이의 제제
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
DK2739311T3 (en) 2011-08-04 2018-04-23 Amgen Inc Method of treating bone slit defects
KR20200056473A (ko) 2011-12-28 2020-05-22 암젠 인크 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
EP2869844B2 (fr) 2012-07-05 2023-06-21 UCB Pharma S.A. Traitement de maladies osseuses
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
ES2732925T3 (es) 2014-07-18 2019-11-26 Sanofi Sa Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
AU2019243595A1 (en) 2018-03-30 2020-09-17 Amgen Inc. C-terminal antibody variants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256568A (en) 1990-02-12 1993-10-26 Regeneron Phamaceuticals, Inc. Vectors and transformed most cells for recombinant protein production with reduced expression of selectable markers
DE69121208T2 (de) 1990-09-25 1997-01-23 Genentech Inc Neuer neurotropischer faktor
IL134656A (en) * 1992-09-03 2006-12-10 Univ California Antibodies that bind the polypeptide nogin and hybridoma capable of producing these antibodies
WO1994005800A1 (fr) * 1992-09-03 1994-03-17 The Regents Of The University Of California Facteur influant sur le tissu dorsal et compositions

Also Published As

Publication number Publication date
ATE252639T1 (de) 2003-11-15
EP1003860B1 (fr) 2003-10-22
HK1026229A1 (en) 2000-12-08
EP1003860A1 (fr) 2000-05-31
JP2001510044A (ja) 2001-07-31
AU8570898A (en) 1999-02-10
CA2296769C (fr) 2008-01-15
US6500640B1 (en) 2002-12-31
WO1999003996A1 (fr) 1999-01-28
DE69819167T2 (de) 2004-07-22
US6075007A (en) 2000-06-13
DE69819167D1 (de) 2003-11-27
CA2296769A1 (fr) 1999-01-28
US20030129703A1 (en) 2003-07-10
IL134042A (en) 2006-12-10
JP4181300B2 (ja) 2008-11-12
AU735851B2 (en) 2001-07-19

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Legal Events

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FF Patent granted
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