IL132740A0 - Complex formation between dsdna and oligomer of heterocycles - Google Patents
Complex formation between dsdna and oligomer of heterocyclesInfo
- Publication number
- IL132740A0 IL132740A0 IL13274097A IL13274097A IL132740A0 IL 132740 A0 IL132740 A0 IL 132740A0 IL 13274097 A IL13274097 A IL 13274097A IL 13274097 A IL13274097 A IL 13274097A IL 132740 A0 IL132740 A0 IL 132740A0
- Authority
- IL
- Israel
- Prior art keywords
- dsdna
- heterocycles
- oligomer
- complex formation
- complex
- Prior art date
Links
- 102000053602 DNA Human genes 0.000 title 1
- 108020004414 DNA Proteins 0.000 title 1
- 230000009918 complex formation Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/853,522 US6635417B1 (en) | 1996-07-31 | 1997-05-08 | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| PCT/US1997/012722 WO1998050582A1 (en) | 1997-05-08 | 1997-07-21 | COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132740A0 true IL132740A0 (en) | 2001-03-19 |
Family
ID=25316259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13274097A IL132740A0 (en) | 1997-05-08 | 1997-07-21 | Complex formation between dsdna and oligomer of heterocycles |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6635417B1 (https=) |
| EP (1) | EP1007729A4 (https=) |
| JP (1) | JP2002514082A (https=) |
| AU (1) | AU746656B2 (https=) |
| CA (1) | CA2288806A1 (https=) |
| IL (1) | IL132740A0 (https=) |
| WO (1) | WO1998050582A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6255298A (en) * | 1996-02-26 | 1998-09-09 | California Institute Of Technology | Design, synthesis and use of specific polyamide dna-binding ligands |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| US7078536B2 (en) | 2001-03-14 | 2006-07-18 | Genesoft Pharmaceuticals, Inc. | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
| CN1427839A (zh) | 2000-03-16 | 2003-07-02 | 根索福特股份有限公司 | 含有核酸结合部分的带电荷化合物及其用途 |
| GB0011938D0 (en) * | 2000-05-17 | 2000-07-05 | Angeletti P Ist Richerche Bio | Improvements relating to gene delivery systems |
| US6777425B2 (en) | 2001-06-13 | 2004-08-17 | Genesoft Pharmaceuticals, Inc. | Isoquinoline compounds having antiinfective activity |
| US6716866B2 (en) | 2001-06-13 | 2004-04-06 | Genesoft Pharmaceuticals, Inc. | Aryl-benzimidazole compounds having antiinfective activity |
| US20030236198A1 (en) | 2001-06-13 | 2003-12-25 | Genesoft, Inc. | Antipathogenic benzamide compounds |
| EP1470119A4 (en) | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY |
| CA2458926A1 (en) * | 2001-09-13 | 2003-03-13 | Genesoft Pharmaceuticals, Inc. | Methods of treating infection by drug resistant bacteria |
| ATE425753T1 (de) | 2002-08-02 | 2009-04-15 | Genesoft Pharmaceuticals Inc | Biaryl-verbindungen mit antiinfektiver wirkung |
| EP1562931A2 (en) | 2002-10-25 | 2005-08-17 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| AU2003297822A1 (en) | 2002-12-10 | 2004-06-30 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
| CA2531869A1 (en) * | 2003-04-30 | 2004-11-18 | Pharmacia Corporation | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna |
| US20060174364A1 (en) * | 2004-03-01 | 2006-08-03 | Avigenics, Inc. | Artificial chromosomes and transchromosomic avians |
| WO2005112924A2 (en) * | 2004-04-27 | 2005-12-01 | California Institute Of Technology | Methods of treating cancer by inhibiting histone gene expression |
| US20060025429A1 (en) * | 2004-06-07 | 2006-02-02 | Dervan Peter B | Composition and methods for inhibiting expression of hypoxia-inducible genes |
| GB0619325D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| WO2008066890A2 (en) * | 2006-11-29 | 2008-06-05 | California Institute Of Technology | Polyamides with tail structures |
| WO2008133877A1 (en) * | 2007-04-23 | 2008-11-06 | California Institute Of Technology | Inhibitors for steroid response elements and related methods |
| US9630950B2 (en) | 2007-04-23 | 2017-04-25 | California Institute Of Technology | Inhibitors for steroid response elements and RNA polymerase II and related methods |
| WO2013033658A1 (en) | 2011-09-02 | 2013-03-07 | Northwestern University | Self-assembled nanostructures |
| WO2018044817A1 (en) | 2016-08-29 | 2018-03-08 | California Institute Of Technology | Compositions and methods for treatment of prostate cancer |
| JP7522726B2 (ja) | 2019-03-28 | 2024-07-25 | 株式会社カネカ | ピロールイミダゾール（ポリ）アミドの製造方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795700A (en) * | 1985-01-25 | 1989-01-03 | California Institute Of Technology | Nucleic acid probes and methods of using same |
| GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| CA1308516C (en) * | 1987-07-06 | 1992-10-06 | The Governors Of The University Of Alberta | Oligopeptide anticancer and antiviral agents |
| GB8906709D0 (en) | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| CA2005039A1 (en) | 1989-12-08 | 1991-06-08 | Randell L. Mills | Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis |
| US5459255A (en) * | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| AU1224392A (en) | 1991-02-06 | 1992-09-07 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| IT1247878B (it) | 1991-02-15 | 1995-01-05 | Menarini Farma Ind | Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono |
| US5578444A (en) | 1991-06-27 | 1996-11-26 | Genelabs Technologies, Inc. | Sequence-directed DNA-binding molecules compositions and methods |
| WO1993000446A1 (en) | 1991-06-27 | 1993-01-07 | Genelabs Technologies, Inc. | Screening assay for the detection of dna-binding molecules |
| US5726014A (en) | 1991-06-27 | 1998-03-10 | Genelabs Technologies, Inc. | Screening assay for the detection of DNA-binding molecules |
| GB2261661A (en) | 1991-11-21 | 1993-05-26 | Erba Carlo Spa | Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles |
| US5273991A (en) | 1992-07-29 | 1993-12-28 | Research Corporation Technologies, Inc. | Imidazole-containing compositions and methods of use thereof analogs of distamycin |
| IT1271456B (it) | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
| IT1263089B (it) | 1993-04-26 | 1996-07-24 | Menarini Farma Ind | Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono. |
| AU7380294A (en) * | 1993-08-06 | 1995-02-28 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| US5698674A (en) | 1994-04-13 | 1997-12-16 | The Regents Of The University Of California | Triheterocyclic peptides capable of binding the minor and major grooves of DNA |
| GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| GB9514993D0 (en) | 1995-07-21 | 1995-09-20 | Pharmacia Spa | Site specific phenyl nitrogen mustards |
| EA199800675A1 (ru) | 1996-02-01 | 1999-02-25 | Мерк Фросст Кэнада Инк. | Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2) |
| US6090947A (en) | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
| US6143901A (en) * | 1996-07-31 | 2000-11-07 | Genesoft, Inc. | Complex formation between dsDNA and pyrrole imidazole polyamides |
-
1997
- 1997-05-08 US US08/853,522 patent/US6635417B1/en not_active Expired - Lifetime
- 1997-07-21 IL IL13274097A patent/IL132740A0/xx not_active IP Right Cessation
- 1997-07-21 WO PCT/US1997/012722 patent/WO1998050582A1/en not_active Ceased
- 1997-07-21 JP JP54801098A patent/JP2002514082A/ja not_active Ceased
- 1997-07-21 EP EP97939339A patent/EP1007729A4/en not_active Withdrawn
- 1997-07-21 AU AU41450/97A patent/AU746656B2/en not_active Ceased
- 1997-07-21 CA CA002288806A patent/CA2288806A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU746656B2 (en) | 2002-05-02 |
| EP1007729A4 (en) | 2006-05-17 |
| CA2288806A1 (en) | 1998-11-12 |
| AU4145097A (en) | 1998-11-27 |
| US6635417B1 (en) | 2003-10-21 |
| EP1007729A1 (en) | 2000-06-14 |
| WO1998050582A1 (en) | 1998-11-12 |
| JP2002514082A (ja) | 2002-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |