CA2288806A1 - Complex formation between dsdna and oligomer of heterocycles - Google Patents

Complex formation between dsdna and oligomer of heterocycles Download PDF

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Publication number
CA2288806A1
CA2288806A1 CA002288806A CA2288806A CA2288806A1 CA 2288806 A1 CA2288806 A1 CA 2288806A1 CA 002288806 A CA002288806 A CA 002288806A CA 2288806 A CA2288806 A CA 2288806A CA 2288806 A1 CA2288806 A1 CA 2288806A1
Authority
CA
Canada
Prior art keywords
heterocycles
oligomers
oligomer
dsdna
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002288806A
Other languages
English (en)
French (fr)
Inventor
Peter B. Dervan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2288806A1 publication Critical patent/CA2288806A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002288806A 1997-05-08 1997-07-21 Complex formation between dsdna and oligomer of heterocycles Abandoned CA2288806A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/853,522 US6635417B1 (en) 1996-07-31 1997-05-08 Complex formation between DSDNA and oligomer of cyclic heterocycles
PCT/US1997/012722 WO1998050582A1 (en) 1997-05-08 1997-07-21 COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES
US08/853,522 1997-07-21

Publications (1)

Publication Number Publication Date
CA2288806A1 true CA2288806A1 (en) 1998-11-12

Family

ID=25316259

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002288806A Abandoned CA2288806A1 (en) 1997-05-08 1997-07-21 Complex formation between dsdna and oligomer of heterocycles

Country Status (7)

Country Link
US (1) US6635417B1 (https=)
EP (1) EP1007729A4 (https=)
JP (1) JP2002514082A (https=)
AU (1) AU746656B2 (https=)
CA (1) CA2288806A1 (https=)
IL (1) IL132740A0 (https=)
WO (1) WO1998050582A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6255298A (en) * 1996-02-26 1998-09-09 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
CN1427839A (zh) 2000-03-16 2003-07-02 根索福特股份有限公司 含有核酸结合部分的带电荷化合物及其用途
GB0011938D0 (en) * 2000-05-17 2000-07-05 Angeletti P Ist Richerche Bio Improvements relating to gene delivery systems
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
US6716866B2 (en) 2001-06-13 2004-04-06 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
US20030236198A1 (en) 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
EP1470119A4 (en) 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
CA2458926A1 (en) * 2001-09-13 2003-03-13 Genesoft Pharmaceuticals, Inc. Methods of treating infection by drug resistant bacteria
ATE425753T1 (de) 2002-08-02 2009-04-15 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
EP1562931A2 (en) 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003297822A1 (en) 2002-12-10 2004-06-30 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
CA2531869A1 (en) * 2003-04-30 2004-11-18 Pharmacia Corporation Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna
US20060174364A1 (en) * 2004-03-01 2006-08-03 Avigenics, Inc. Artificial chromosomes and transchromosomic avians
WO2005112924A2 (en) * 2004-04-27 2005-12-01 California Institute Of Technology Methods of treating cancer by inhibiting histone gene expression
US20060025429A1 (en) * 2004-06-07 2006-02-02 Dervan Peter B Composition and methods for inhibiting expression of hypoxia-inducible genes
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
WO2008066890A2 (en) * 2006-11-29 2008-06-05 California Institute Of Technology Polyamides with tail structures
WO2008133877A1 (en) * 2007-04-23 2008-11-06 California Institute Of Technology Inhibitors for steroid response elements and related methods
US9630950B2 (en) 2007-04-23 2017-04-25 California Institute Of Technology Inhibitors for steroid response elements and RNA polymerase II and related methods
WO2013033658A1 (en) 2011-09-02 2013-03-07 Northwestern University Self-assembled nanostructures
WO2018044817A1 (en) 2016-08-29 2018-03-08 California Institute Of Technology Compositions and methods for treatment of prostate cancer
JP7522726B2 (ja) 2019-03-28 2024-07-25 株式会社カネカ ピロールイミダゾール（ポリ）アミドの製造方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795700A (en) * 1985-01-25 1989-01-03 California Institute Of Technology Nucleic acid probes and methods of using same
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
CA1308516C (en) * 1987-07-06 1992-10-06 The Governors Of The University Of Alberta Oligopeptide anticancer and antiviral agents
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
CA2005039A1 (en) 1989-12-08 1991-06-08 Randell L. Mills Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
AU1224392A (en) 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1247878B (it) 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
US5578444A (en) 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
WO1993000446A1 (en) 1991-06-27 1993-01-07 Genelabs Technologies, Inc. Screening assay for the detection of dna-binding molecules
US5726014A (en) 1991-06-27 1998-03-10 Genelabs Technologies, Inc. Screening assay for the detection of DNA-binding molecules
GB2261661A (en) 1991-11-21 1993-05-26 Erba Carlo Spa Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles
US5273991A (en) 1992-07-29 1993-12-28 Research Corporation Technologies, Inc. Imidazole-containing compositions and methods of use thereof analogs of distamycin
IT1271456B (it) 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
IT1263089B (it) 1993-04-26 1996-07-24 Menarini Farma Ind Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.
AU7380294A (en) * 1993-08-06 1995-02-28 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
US5698674A (en) 1994-04-13 1997-12-16 The Regents Of The University Of California Triheterocyclic peptides capable of binding the minor and major grooves of DNA
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
GB9514993D0 (en) 1995-07-21 1995-09-20 Pharmacia Spa Site specific phenyl nitrogen mustards
EA199800675A1 (ru) 1996-02-01 1999-02-25 Мерк Фросст Кэнада Инк. Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2)
US6090947A (en) 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides

Also Published As

Publication number Publication date
AU746656B2 (en) 2002-05-02
EP1007729A4 (en) 2006-05-17
AU4145097A (en) 1998-11-27
US6635417B1 (en) 2003-10-21
IL132740A0 (en) 2001-03-19
EP1007729A1 (en) 2000-06-14
WO1998050582A1 (en) 1998-11-12
JP2002514082A (ja) 2002-05-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued