IL127661A - Dual inoculant pharmaceutical preparation including an artificial target antigen - Google Patents
Dual inoculant pharmaceutical preparation including an artificial target antigenInfo
- Publication number
- IL127661A IL127661A IL12766197A IL12766197A IL127661A IL 127661 A IL127661 A IL 127661A IL 12766197 A IL12766197 A IL 12766197A IL 12766197 A IL12766197 A IL 12766197A IL 127661 A IL127661 A IL 127661A
- Authority
- IL
- Israel
- Prior art keywords
- tumor
- cells
- target antigen
- artificial target
- antigen
- Prior art date
Links
- 108091007433 antigens Proteins 0.000 title claims abstract description 148
- 102000036639 antigens Human genes 0.000 title claims abstract description 148
- 239000000427 antigen Substances 0.000 title claims abstract description 144
- 239000002054 inoculum Substances 0.000 title claims abstract description 21
- 230000009977 dual effect Effects 0.000 title claims abstract description 9
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 8
- 210000004027 cell Anatomy 0.000 claims abstract description 88
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 56
- 230000001404 mediated effect Effects 0.000 claims abstract description 21
- 230000004044 response Effects 0.000 claims abstract description 17
- 230000001737 promoting effect Effects 0.000 claims abstract description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 110
- 238000000034 method Methods 0.000 claims description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
- 210000000448 cultured tumor cell Anatomy 0.000 claims description 19
- 230000028993 immune response Effects 0.000 claims description 18
- 102000011931 Nucleoproteins Human genes 0.000 claims description 14
- 108010061100 Nucleoproteins Proteins 0.000 claims description 14
- 101000609762 Gallus gallus Ovalbumin Proteins 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- 241000712461 unidentified influenza virus Species 0.000 claims description 13
- 230000002163 immunogen Effects 0.000 claims description 12
- 230000003612 virological effect Effects 0.000 claims description 12
- 238000001890 transfection Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 108010010995 MART-1 Antigen Proteins 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 108060003552 hemocyanin Proteins 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 208000002672 hepatitis B Diseases 0.000 claims description 3
- 230000000415 inactivating effect Effects 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims 2
- 102000016200 MART-1 Antigen Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000003053 immunization Effects 0.000 description 104
- 238000002649 immunization Methods 0.000 description 103
- 108010058846 Ovalbumin Proteins 0.000 description 69
- 229940092253 ovalbumin Drugs 0.000 description 64
- 241000699670 Mus sp. Species 0.000 description 60
- 108090000623 proteins and genes Proteins 0.000 description 32
- 102000004169 proteins and genes Human genes 0.000 description 29
- 201000001441 melanoma Diseases 0.000 description 27
- 230000036039 immunity Effects 0.000 description 25
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 25
- 108091054437 MHC class I family Proteins 0.000 description 24
- 102000043129 MHC class I family Human genes 0.000 description 22
- 239000011324 bead Substances 0.000 description 21
- 238000000338 in vitro Methods 0.000 description 21
- 241001465754 Metazoa Species 0.000 description 20
- 210000000612 antigen-presenting cell Anatomy 0.000 description 19
- 210000004443 dendritic cell Anatomy 0.000 description 18
- 230000037361 pathway Effects 0.000 description 18
- 239000002953 phosphate buffered saline Substances 0.000 description 16
- 108020004414 DNA Proteins 0.000 description 15
- 230000000890 antigenic effect Effects 0.000 description 15
- 238000001727 in vivo Methods 0.000 description 15
- 241001529936 Murinae Species 0.000 description 14
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 14
- 239000012634 fragment Substances 0.000 description 14
- 239000007924 injection Substances 0.000 description 14
- 238000002347 injection Methods 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 12
- 230000001681 protective effect Effects 0.000 description 12
- 239000013598 vector Substances 0.000 description 11
- 230000000259 anti-tumor effect Effects 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 10
- 210000001744 T-lymphocyte Anatomy 0.000 description 9
- 239000012636 effector Substances 0.000 description 9
- 230000006698 induction Effects 0.000 description 9
- 208000001382 Experimental Melanoma Diseases 0.000 description 8
- 230000001419 dependent effect Effects 0.000 description 8
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 7
- 208000036142 Viral infection Diseases 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 230000009385 viral infection Effects 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 210000004408 hybridoma Anatomy 0.000 description 6
- 231100000518 lethal Toxicity 0.000 description 6
- 230000001665 lethal effect Effects 0.000 description 6
- 230000004614 tumor growth Effects 0.000 description 6
- 238000011740 C57BL/6 mouse Methods 0.000 description 5
- 210000000991 chicken egg Anatomy 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- JVJGCCBAOOWGEO-RUTPOYCXSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-4-amino-2-[[(2s,3s)-2-[[(2s,3s)-2-[[(2s)-2-azaniumyl-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxylatobutanoyl]amino]-6-azaniumy Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)CC1=CC=CC=C1 JVJGCCBAOOWGEO-RUTPOYCXSA-N 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 238000007912 intraperitoneal administration Methods 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 208000008732 thymoma Diseases 0.000 description 4
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- 238000002619 cancer immunotherapy Methods 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000008348 humoral response Effects 0.000 description 3
- 238000009169 immunotherapy Methods 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 230000005923 long-lasting effect Effects 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 210000005170 neoplastic cell Anatomy 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000004989 spleen cell Anatomy 0.000 description 3
- 210000004988 splenocyte Anatomy 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 2
- 101100207408 Homo sapiens TRA gene Proteins 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 108700019146 Transgenes Proteins 0.000 description 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000000139 costimulatory effect Effects 0.000 description 2
- 210000000172 cytosol Anatomy 0.000 description 2
- 210000003595 dermal dendritic cell Anatomy 0.000 description 2
- 230000006862 enzymatic digestion Effects 0.000 description 2
- 210000003426 epidermal langerhans cell Anatomy 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- -1 gplOO Proteins 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000021633 leukocyte mediated immunity Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012737 microarray-based gene expression Methods 0.000 description 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000013600 plasmid vector Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000037455 tumor specific immune response Effects 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- RAUPFUCUDBQYHE-AVGNSLFASA-N Asn-Phe-Glu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O RAUPFUCUDBQYHE-AVGNSLFASA-N 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000331 Firefly luciferases Proteins 0.000 description 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000980756 Homo sapiens G1/S-specific cyclin-D1 Proteins 0.000 description 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
- 108010020194 Influenza Virus Hemagglutinin Glycoproteins Proteins 0.000 description 1
- 102100025390 Integrin beta-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 108091061960 Naked DNA Proteins 0.000 description 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000005809 anti-tumor immunity Effects 0.000 description 1
- 230000006023 anti-tumor response Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000002784 cytotoxicity assay Methods 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000005210 lymphoid organ Anatomy 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- GSSMIHQEWAQUPM-AOLPDKKJSA-N ovalbumin peptide Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CN=CN1 GSSMIHQEWAQUPM-AOLPDKKJSA-N 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 210000000680 phagosome Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
- A61K39/001151—Apoptosis related proteins, e.g. survivin or livin p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001192—Glycoprotein 100 [Gp100]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/675,332 US5951975A (en) | 1996-06-28 | 1996-06-28 | Induction of CTLs specific for natural antigens by cross priming immunization |
| PCT/US1997/010195 WO1998000163A1 (en) | 1996-06-28 | 1997-06-18 | INDUCTION OF CTLs SPECIFIC FOR NATURAL ANTIGENS BY CROSS-PRIMING IMMUNIZATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127661A0 IL127661A0 (en) | 1999-10-28 |
| IL127661A true IL127661A (en) | 2001-11-25 |
Family
ID=24710012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12766197A IL127661A (en) | 1996-06-28 | 1997-06-18 | Dual inoculant pharmaceutical preparation including an artificial target antigen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5951975A (ja) |
| EP (1) | EP1007087A1 (ja) |
| JP (1) | JP2001524928A (ja) |
| AU (1) | AU724546B2 (ja) |
| CA (1) | CA2258840A1 (ja) |
| IL (1) | IL127661A (ja) |
| WO (1) | WO1998000163A1 (ja) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6994851B1 (en) * | 1997-07-10 | 2006-02-07 | Mannkind Corporation | Method of inducing a CTL response |
| US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| US6844188B1 (en) | 1998-04-08 | 2005-01-18 | University Of North Carolina At Chapel Hill | Methods and modified cells for the treatment of cancer |
| ATE457176T1 (de) * | 1998-04-08 | 2010-02-15 | Univ North Carolina | Krebsimpfstoff enthaltend alphavirusrepliconpartikeln |
| WO2000039304A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| CA2358915C (en) | 1998-12-31 | 2010-06-01 | Chiron Corporation | Modified hiv env polypeptides |
| JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| DK1363938T3 (en) * | 2000-08-03 | 2014-03-24 | Univ Johns Hopkins | Molecular vaccine that connects an endoplasmic reticulum-chaperonepolypeptid with an antigen |
| GB0026812D0 (en) * | 2000-11-02 | 2000-12-20 | Isis Innovation | Cancer therapy |
| EP1409009A1 (en) * | 2001-06-15 | 2004-04-21 | Nordic Vaccine Technology A/S | Therapeutical vaccination |
| EP2280074A3 (en) * | 2001-07-05 | 2011-06-22 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| AU2002320314A1 (en) * | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| CA2458995C (en) * | 2001-08-31 | 2013-04-30 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| AU2004232971A1 (en) * | 2003-04-18 | 2004-11-04 | Idm Pharma Inc. | HLA-A2 tumor associated antigen peptides and compositions |
| EP1644048B1 (en) * | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| US7807187B2 (en) * | 2003-05-13 | 2010-10-05 | The University Of Massachusetts | Endogenous adjuvant molecules and uses thereof |
| CA2572921C (en) * | 2004-07-09 | 2017-01-03 | The University Of North Carolina At Chapel Hill | Replication-competent and propagation-defective venezuelan equine encephalitis (vee) viral adjuvants |
| WO2006073970A2 (en) * | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
| WO2006081323A2 (en) * | 2005-01-26 | 2006-08-03 | The Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin |
| WO2007046839A2 (en) * | 2005-02-15 | 2007-04-26 | University Of North Carolina At Chapel Hill | New live virus vaccines |
| WO2008024844A2 (en) * | 2006-08-22 | 2008-02-28 | The Johns Hopkins University | Anticancer combination therapies |
| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| US20080260765A1 (en) * | 2007-03-15 | 2008-10-23 | Johns Hopkins University | HPV DNA Vaccines and Methods of Use Thereof |
| US20090285861A1 (en) * | 2008-04-17 | 2009-11-19 | Tzyy-Choou Wu | Tumor cell-based cancer immunotherapeutic compositions and methods |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| WO2018222989A1 (en) * | 2017-06-02 | 2018-12-06 | The Penn State Research Foundation | Ceramide nanoliposomes, compositions and methods of using for immunotherapy |
| US20220401545A1 (en) * | 2019-08-13 | 2022-12-22 | National Institute of Biomedical Innovation, Health and Nutrition | Novel treatment and prevention of disease based on immunological memory |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045320A (en) * | 1989-03-23 | 1991-09-03 | Medical Biology Institute | Large multivalent immunogen |
| US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| DK0749323T3 (da) * | 1994-03-08 | 2001-02-05 | Dana Farber Cancer Inst Inc | Fremgangsmåder til modulering af T-celle-anergi |
-
1996
- 1996-06-28 US US08/675,332 patent/US5951975A/en not_active Expired - Fee Related
-
1997
- 1997-06-18 IL IL12766197A patent/IL127661A/en not_active IP Right Cessation
- 1997-06-18 JP JP50415598A patent/JP2001524928A/ja not_active Ceased
- 1997-06-18 WO PCT/US1997/010195 patent/WO1998000163A1/en not_active Application Discontinuation
- 1997-06-18 AU AU33900/97A patent/AU724546B2/en not_active Ceased
- 1997-06-18 CA CA002258840A patent/CA2258840A1/en not_active Abandoned
- 1997-06-18 EP EP97929960A patent/EP1007087A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL127661A0 (en) | 1999-10-28 |
| AU724546B2 (en) | 2000-09-28 |
| JP2001524928A (ja) | 2001-12-04 |
| WO1998000163A1 (en) | 1998-01-08 |
| AU3390097A (en) | 1998-01-21 |
| CA2258840A1 (en) | 1998-01-08 |
| EP1007087A1 (en) | 2000-06-14 |
| US5951975A (en) | 1999-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU724546B2 (en) | Induction of CTLs specific for natural antigens by cross-priming immunization | |
| WO1998000163A9 (en) | INDUCTION OF CTLs SPECIFIC FOR NATURAL ANTIGENS BY CROSS-PRIMING IMMUNIZATION | |
| Falo Jr et al. | Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity | |
| Chen et al. | Experimental vaccine strategies for cancer immunotherapy | |
| US7670611B2 (en) | Cancer immunotherapy with semi-allogeneic cells | |
| US10799553B2 (en) | Composition comprising a nucleotide sequence encoding an ELA2 fusion protein and plasmacytoid dendritic cells | |
| Irvine et al. | Efficient nonviral transfection of dendritic cells and their use for in vivo immunization | |
| HU211299A9 (en) | Induction of cytotoxic t-lymphocyte responses | |
| Kjaergaard et al. | Electrofusion of syngeneic dendritic cells and tumor generates potent therapeutic vaccine | |
| US20040028663A1 (en) | Combined immunotherapy of fusion cells and interleukin-12 for treatment of cancer | |
| Mesa et al. | Very small size proteoliposomes derived from Neisseria meningitidis: an effective adjuvant for generation of CTL responses to peptide and protein antigens | |
| Saha et al. | Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity | |
| AU716497B2 (en) | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization | |
| US7176186B1 (en) | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization | |
| Yi | Dendritic cell-based immunotherapy in multiple myeloma | |
| JP2006515608A (ja) | ワクチンとして使用するためのハイブリッドベクター系 | |
| Teramoto et al. | Deoxyribonucleic acid (DNA) encoding a pan-major histocompatibility complex class II peptide analogue augmented antigen-specific cellular immunity and suppressive effects on tumor growth elicited by DNA vaccine immunotherapy | |
| Jang et al. | Simultaneous expression of allogenic class II MHC and B7. 1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity | |
| JP2001501220A (ja) | オンコジーン産物および外来ｍｈｃ分子を用いる癌治療 | |
| Paterson | Rational approaches to immune regulation | |
| US20060153821A1 (en) | Induction of tumor and viral immunity using antigen presenting cell co-culture products and fusion products | |
| Ruffini et al. | Genetic idiotypic and tumor cell-based vaccine strategies for indolent non Hodgkin's lymphoma | |
| Ashour et al. | Effect of linkage of transduction domain sequences to a lymphoma idiotype DNA vaccine on vaccine effectiveness | |
| Lou et al. | B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells | |
| Stevenson et al. | DNA vaccines against B-cell tumors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9K | Patent not in force due to non-payment of renewal fees |