IL125821A0 - A pharmaceutical composition containing dehydroepiandrosterone and aromatase inhibitors and use thereof - Google Patents
A pharmaceutical composition containing dehydroepiandrosterone and aromatase inhibitors and use thereofInfo
- Publication number
- IL125821A0 IL125821A0 IL12582197A IL12582197A IL125821A0 IL 125821 A0 IL125821 A0 IL 125821A0 IL 12582197 A IL12582197 A IL 12582197A IL 12582197 A IL12582197 A IL 12582197A IL 125821 A0 IL125821 A0 IL 125821A0
- Authority
- IL
- Israel
- Prior art keywords
- aromatase inhibitors
- pharmaceutical composition
- composition containing
- dehydroepiandrosterone
- containing dehydroepiandrosterone
- Prior art date
Links
- 239000003886 aromatase inhibitor Substances 0.000 title abstract 3
- 229940046844 aromatase inhibitors Drugs 0.000 title abstract 2
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 title abstract 2
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960002847 prasterone Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 abstract 1
- 206010002261 Androgen deficiency Diseases 0.000 abstract 1
- 229940122815 Aromatase inhibitor Drugs 0.000 abstract 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 abstract 1
- -1 aramidex Chemical compound 0.000 abstract 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 abstract 1
- 229960003881 letrozole Drugs 0.000 abstract 1
- XLMPPFTZALNBFS-INIZCTEOSA-N vorozole Chemical compound C1([C@@H](C2=CC=C3N=NN(C3=C2)C)N2N=CN=C2)=CC=C(Cl)C=C1 XLMPPFTZALNBFS-INIZCTEOSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19610645A DE19610645A1 (de) | 1996-03-06 | 1996-03-06 | Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann |
| PCT/DE1997/000518 WO1997032588A2 (de) | 1996-03-06 | 1997-03-06 | Kombination von dehydroepiandrosteron und aromatasehemmern und verwendung dieser kombination zur herstellung eines arzneimittels zur behandlung eines relativen und absoluten androgenmangels beim mann |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL125821A0 true IL125821A0 (en) | 1999-04-11 |
Family
ID=7788665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12582197A IL125821A0 (en) | 1996-03-06 | 1997-03-06 | A pharmaceutical composition containing dehydroepiandrosterone and aromatase inhibitors and use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6696432B1 (xx) |
| EP (1) | EP0885005B1 (xx) |
| JP (1) | JP2000506844A (xx) |
| KR (1) | KR19990087573A (xx) |
| AT (1) | ATE247968T1 (xx) |
| AU (1) | AU730777B2 (xx) |
| BR (1) | BR9707844A (xx) |
| CA (1) | CA2248251A1 (xx) |
| DE (2) | DE19610645A1 (xx) |
| DK (1) | DK0885005T3 (xx) |
| ES (1) | ES2206706T3 (xx) |
| HU (1) | HUP9901505A3 (xx) |
| IL (1) | IL125821A0 (xx) |
| NO (1) | NO984075L (xx) |
| PL (1) | PL328709A1 (xx) |
| PT (1) | PT885005E (xx) |
| WO (1) | WO1997032588A2 (xx) |
| ZA (1) | ZA971965B (xx) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001283964A1 (en) * | 2000-08-09 | 2002-02-18 | Pharmacia And Upjohn Company | Composition for combined use of aromatase inhibitors |
| WO2003017973A1 (en) * | 2001-08-31 | 2003-03-06 | Pantarhei Bioscience B.V. | A method of treating benign gynaecological disorders and a drug delivery vehicle for use in such a method |
| US20040235812A1 (en) * | 2002-04-03 | 2004-11-25 | Caspers Robert F | Pharmaceutical composition comprisng an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male |
| AU2012200290B2 (en) * | 2005-10-19 | 2014-08-21 | Havah Therapeutics Pty Ltd | Reduction of side effects from aromatase inhibitors used for treating breast cancer |
| AU2006303878B2 (en) * | 2005-10-19 | 2011-10-20 | Havah Therapeutics Pty Ltd | Reduction of side effects from aromatase inhibitors used for treating breast cancer |
| US20090215731A1 (en) * | 2005-10-19 | 2009-08-27 | Chavah Pty Ltd. | Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer |
| US7874032B2 (en) * | 2008-06-24 | 2011-01-25 | Vaughn North | Method and device for maintaining a side sleeping position |
| US9744177B2 (en) * | 2014-03-10 | 2017-08-29 | Endorecherche, Inc. | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM |
| US10213440B2 (en) | 2014-08-20 | 2019-02-26 | Professional Compounding Centers Of America (Pcca) | Oral transmucosal pharmaceutical compositions including testosterone and an aromatase inhibitor |
| ES2953915T3 (es) | 2014-10-22 | 2023-11-17 | Havah Therapeutics Pty Ltd | Métodos para reducir la densidad mamaria mamográfica y/o el riesgo de cáncer de mama |
| CN108472302A (zh) | 2015-10-22 | 2018-08-31 | 哈瓦赫治疗有限公司 | 降低乳房摄影乳腺密度和/或乳腺癌风险的方法 |
| WO2020243777A1 (en) | 2019-06-03 | 2020-12-10 | Havah Therapeutics Pty Ltd | Pharmaceutical formulations and systems for delivery of an androgenic agent and an aromatase inhibitor and methods for use |
| CN115554403B (zh) * | 2022-08-16 | 2024-03-08 | 山东大学 | 类固醇激素dhea作为受体adgrg2激动剂配体的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835147A (en) | 1987-05-06 | 1989-05-30 | City Of Hope | Dehydroepiandrosterone therapy for ameleoration of prostate hypertrophy and sexual dysfunction |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| ES2189784T3 (es) * | 1989-07-07 | 2003-07-16 | Endorech Inc | Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos. |
| NZ256130A (en) | 1992-09-30 | 1996-05-28 | Teikoku Hormone Mfg Co Ltd | 7-substituted oxasteroid derivatives; pharmaceutical compositions |
| DE4435368A1 (de) | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
-
1996
- 1996-03-06 DE DE19610645A patent/DE19610645A1/de not_active Withdrawn
-
1997
- 1997-03-06 US US09/142,226 patent/US6696432B1/en not_active Expired - Fee Related
- 1997-03-06 DK DK97920511T patent/DK0885005T3/da active
- 1997-03-06 EP EP97920511A patent/EP0885005B1/de not_active Expired - Lifetime
- 1997-03-06 DE DE59710660T patent/DE59710660D1/de not_active Expired - Fee Related
- 1997-03-06 ES ES97920511T patent/ES2206706T3/es not_active Expired - Lifetime
- 1997-03-06 PL PL97328709A patent/PL328709A1/xx unknown
- 1997-03-06 CA CA002248251A patent/CA2248251A1/en not_active Abandoned
- 1997-03-06 BR BR9707844A patent/BR9707844A/pt not_active IP Right Cessation
- 1997-03-06 ZA ZA9701965A patent/ZA971965B/xx unknown
- 1997-03-06 KR KR1019980707012A patent/KR19990087573A/ko not_active Application Discontinuation
- 1997-03-06 AU AU26902/97A patent/AU730777B2/en not_active Ceased
- 1997-03-06 WO PCT/DE1997/000518 patent/WO1997032588A2/de not_active Application Discontinuation
- 1997-03-06 IL IL12582197A patent/IL125821A0/xx unknown
- 1997-03-06 PT PT97920511T patent/PT885005E/pt unknown
- 1997-03-06 HU HU9901505A patent/HUP9901505A3/hu unknown
- 1997-03-06 AT AT97920511T patent/ATE247968T1/de not_active IP Right Cessation
- 1997-03-06 JP JP9531360A patent/JP2000506844A/ja active Pending
-
1998
- 1998-09-04 NO NO984075A patent/NO984075L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE247968T1 (de) | 2003-09-15 |
| CA2248251A1 (en) | 1997-09-12 |
| DE19610645A1 (de) | 1997-09-11 |
| DE59710660D1 (de) | 2003-10-02 |
| WO1997032588A3 (de) | 1997-10-16 |
| PL328709A1 (en) | 1999-02-15 |
| NO984075D0 (no) | 1998-09-04 |
| AU2690297A (en) | 1997-09-22 |
| BR9707844A (pt) | 1999-07-27 |
| ES2206706T3 (es) | 2004-05-16 |
| EP0885005A2 (de) | 1998-12-23 |
| HUP9901505A2 (hu) | 1999-09-28 |
| AU730777B2 (en) | 2001-03-15 |
| JP2000506844A (ja) | 2000-06-06 |
| EP0885005B1 (de) | 2003-08-27 |
| NO984075L (no) | 1998-09-04 |
| PT885005E (pt) | 2004-01-30 |
| KR19990087573A (ko) | 1999-12-27 |
| ZA971965B (en) | 1997-09-10 |
| WO1997032588A2 (de) | 1997-09-12 |
| HUP9901505A3 (en) | 2000-05-29 |
| US6696432B1 (en) | 2004-02-24 |
| DK0885005T3 (da) | 2003-12-15 |
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