IL122455A0 - Hapten modified tumor cell extract and methods of treating or screening for cancer - Google Patents
Hapten modified tumor cell extract and methods of treating or screening for cancerInfo
- Publication number
- IL122455A0 IL122455A0 IL12245596A IL12245596A IL122455A0 IL 122455 A0 IL122455 A0 IL 122455A0 IL 12245596 A IL12245596 A IL 12245596A IL 12245596 A IL12245596 A IL 12245596A IL 122455 A0 IL122455 A0 IL 122455A0
- Authority
- IL
- Israel
- Prior art keywords
- cancer
- tumor cell
- modified tumor
- screening
- methods
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 4
- 239000000284 extract Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000004881 tumor cell Anatomy 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 230000016396 cytokine production Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Environmental Sciences (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47901695A | 1995-06-07 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL122455A0 true IL122455A0 (en) | 1998-06-15 |
Family
ID=23902311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12245596A IL122455A0 (en) | 1995-06-07 | 1996-06-06 | Hapten modified tumor cell extract and methods of treating or screening for cancer |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0837687B1 (xx) |
| JP (1) | JPH11507633A (xx) |
| KR (1) | KR19990022592A (xx) |
| AT (1) | ATE386535T1 (xx) |
| AU (1) | AU727316B2 (xx) |
| BR (1) | BR9609026A (xx) |
| CA (1) | CA2222135A1 (xx) |
| DE (1) | DE69637440T2 (xx) |
| ES (1) | ES2302337T3 (xx) |
| IL (1) | IL122455A0 (xx) |
| WO (1) | WO1996040173A1 (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL328790A1 (en) * | 1996-10-04 | 1999-02-15 | Univ Jefferson | T-lymphocytes provoking an immunological response and methods of using them |
| WO2000009140A1 (en) | 1997-07-24 | 2000-02-24 | Thomas Jefferson University | Composition and method of using tumor cells |
| PL342856A1 (en) * | 1998-02-17 | 2001-07-16 | Univ Jefferson | Hapten-modified tumor cell membranes, and methods of making and using hapten-modified tumor cell membranes |
| WO1999052546A2 (en) * | 1998-04-09 | 1999-10-21 | Thomas Jefferson University | A method of inducing an anti-tumor response against a lung metastasis in a melanoma patient |
| PL347981A1 (en) * | 1998-05-04 | 2002-05-06 | Univ Jefferson | Composition comprising tumor cells and extracts and method of using thereof |
| US6248585B1 (en) | 1998-11-19 | 2001-06-19 | Thomas Jefferson University | Compositions for preserving haptenized tumor cells for use in vaccines |
| WO2000031542A1 (en) * | 1998-11-24 | 2000-06-02 | Thomas Jefferson University | Detection of t cell stimulating tumor antigens |
| AU2487500A (en) * | 1998-12-30 | 2000-07-31 | Thomas Jefferson University | Dual hapten modified tumor cells and tumor polypeptides and methods of treating cancer |
| WO2000057911A2 (en) * | 1999-03-16 | 2000-10-05 | Thomas Jefferson University | Hapten-conjugated mammalian cells and methods of making and using thereof |
| US7297330B2 (en) * | 2000-02-04 | 2007-11-20 | Thomas Jefferson University | Low dose haptenized tumor cell and tumor cell extract immunotherapy |
| US20040076646A1 (en) * | 2001-07-18 | 2004-04-22 | Caplan Michael J. | Haptenizing cancer cell components |
| CA2489076A1 (en) | 2002-06-10 | 2003-12-18 | Avax Technologies Inc. | Cryopreservation of haptenized tumor cells |
| US7598030B2 (en) * | 2004-07-10 | 2009-10-06 | Alexion Pharmaceuticals, Inc. | Antibodies against cancer produced using masked cancer cells as immunogen |
| US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| WO2019165195A1 (en) | 2018-02-22 | 2019-08-29 | Srivastava Satish | Combination therapy for the treatment of cancer |
| AU2019346403A1 (en) * | 2018-09-24 | 2021-04-29 | BioVaxys Inc. | Bihaptenized autologous vaccines and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0268640A4 (en) * | 1986-05-07 | 1989-11-30 | Sloan Kettering Inst Cancer | VACCINE STIMULATING OR IMPROVING THE PRODUCTION OF ANTIBODIES AGAINST GM2. |
| US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
| GB2218420B (en) * | 1988-04-12 | 1992-07-15 | British Bio Technology | Synthetic gene encoding interleukin 4 |
| EP0466813A4 (en) * | 1989-04-05 | 1992-07-15 | Peter Y. S Fung | Active specific immunotherapy of adenocarcinomas producing immunosuppressive mucins |
| US5290551A (en) * | 1990-05-08 | 1994-03-01 | Thomas Jefferson University | Treatment of melanoma with a vaccine comprising irradiated autologous melanoma tumor cells conjugated to a hapten |
| WO1995015334A1 (en) * | 1993-11-30 | 1995-06-08 | California Pacific Medical Center Research Institute | cDNA PROBE FOR BREAST CANCER DIAGNOSIS AND TREATMENT |
| US7297330B2 (en) * | 2000-02-04 | 2007-11-20 | Thomas Jefferson University | Low dose haptenized tumor cell and tumor cell extract immunotherapy |
-
1996
- 1996-06-06 EP EP96921381A patent/EP0837687B1/en not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009511 patent/WO1996040173A1/en active IP Right Grant
- 1996-06-06 KR KR1019970709073A patent/KR19990022592A/ko not_active Application Discontinuation
- 1996-06-06 AT AT96921381T patent/ATE386535T1/de not_active IP Right Cessation
- 1996-06-06 DE DE69637440T patent/DE69637440T2/de not_active Expired - Lifetime
- 1996-06-06 JP JP9501816A patent/JPH11507633A/ja not_active Withdrawn
- 1996-06-06 CA CA002222135A patent/CA2222135A1/en not_active Abandoned
- 1996-06-06 ES ES96921381T patent/ES2302337T3/es not_active Expired - Lifetime
- 1996-06-06 BR BR9609026A patent/BR9609026A/pt unknown
- 1996-06-06 AU AU62620/96A patent/AU727316B2/en not_active Ceased
- 1996-06-06 IL IL12245596A patent/IL122455A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2222135A1 (en) | 1996-12-19 |
| AU6262096A (en) | 1996-12-30 |
| JPH11507633A (ja) | 1999-07-06 |
| DE69637440T2 (de) | 2009-03-05 |
| EP0837687A4 (en) | 2001-06-27 |
| KR19990022592A (ko) | 1999-03-25 |
| EP0837687B1 (en) | 2008-02-20 |
| MX9709733A (es) | 1998-10-31 |
| ES2302337T3 (es) | 2008-07-01 |
| WO1996040173A1 (en) | 1996-12-19 |
| DE69637440D1 (de) | 2008-04-03 |
| AU727316B2 (en) | 2000-12-07 |
| BR9609026A (pt) | 1999-07-06 |
| EP0837687A1 (en) | 1998-04-29 |
| ATE386535T1 (de) | 2008-03-15 |
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