IL119938A - Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells - Google Patents

Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells

Info

Publication number
IL119938A
IL119938A IL11993896A IL11993896A IL119938A IL 119938 A IL119938 A IL 119938A IL 11993896 A IL11993896 A IL 11993896A IL 11993896 A IL11993896 A IL 11993896A IL 119938 A IL119938 A IL 119938A
Authority
IL
Israel
Prior art keywords
cells
immunity against
protective immunity
toxic shock
mediated activation
Prior art date
Application number
IL11993896A
Other languages
English (en)
Other versions
IL119938A0 (en
Inventor
Raymond Kaempfer
Gila Arad
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11993896A priority Critical patent/IL119938A/xx
Publication of IL119938A0 publication Critical patent/IL119938A0/xx
Priority to PCT/IL1997/000438 priority patent/WO1998029444A1/fr
Priority to CA002276112A priority patent/CA2276112A1/fr
Priority to AU78909/98A priority patent/AU7890998A/en
Priority to JP52979598A priority patent/JP2001509014A/ja
Priority to EP97949087A priority patent/EP0952985A1/fr
Priority to US09/150,947 priority patent/US7189398B2/en
Priority to US10/172,425 priority patent/US7060277B2/en
Publication of IL119938A publication Critical patent/IL119938A/xx
Priority to US11/436,610 priority patent/US20060222650A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56944—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11993896A 1996-12-30 1996-12-30 Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells IL119938A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL11993896A IL119938A (en) 1996-12-30 1996-12-30 Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
PCT/IL1997/000438 WO1998029444A1 (fr) 1996-12-30 1997-12-30 Exotoxines pyrogenes a large spectre, antagonistes et vaccins
CA002276112A CA2276112A1 (fr) 1996-12-30 1997-12-30 Exotoxines pyrogenes a large spectre, antagonistes et vaccins
AU78909/98A AU7890998A (en) 1996-12-30 1997-12-30 Broad spectrum pyrogenic exotoxins antagonists and vaccines
JP52979598A JP2001509014A (ja) 1996-12-30 1997-12-30 広範囲スペクトル発熱性外毒素アンタゴニストおよびワクチン
EP97949087A EP0952985A1 (fr) 1996-12-30 1997-12-30 Exotoxines pyrogenes a large spectre, antagonistes et vaccins
US09/150,947 US7189398B2 (en) 1996-12-30 1998-09-10 Broad spectrum pyrogenic exotoxins antagonists and vaccines
US10/172,425 US7060277B2 (en) 1996-12-30 2002-06-13 Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
US11/436,610 US20060222650A1 (en) 1996-12-30 2006-05-19 Broad spectrum pyrogenic antagonists and vaccines directed against pyrogenic exotoxins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11993896A IL119938A (en) 1996-12-30 1996-12-30 Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells

Publications (2)

Publication Number Publication Date
IL119938A0 IL119938A0 (en) 1997-03-18
IL119938A true IL119938A (en) 2005-08-31

Family

ID=11069641

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11993896A IL119938A (en) 1996-12-30 1996-12-30 Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells

Country Status (7)

Country Link
US (1) US7189398B2 (fr)
EP (1) EP0952985A1 (fr)
JP (1) JP2001509014A (fr)
AU (1) AU7890998A (fr)
CA (1) CA2276112A1 (fr)
IL (1) IL119938A (fr)
WO (1) WO1998029444A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517061B (en) * 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
US7060277B2 (en) 1996-12-30 2006-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
US6075119A (en) 1997-04-07 2000-06-13 The Rockefeller University Peptides useful for reducing symptoms of toxic shock syndrome
EP1355662A4 (fr) * 2001-01-10 2006-04-26 Texas A & M Univ Sys Methodes destinees a prevenir les reponses induites par les lymphocytes t au moyen d'une proteine analogue de classe ii a complexe majeur d'histocompatibilite (proteine map) issue de i staphylococcus aureus /i
DE10116042A1 (de) * 2001-03-30 2002-10-24 Fresenius Hemocare Gmbh Exotoxin-Ligand
GB0112126D0 (en) * 2001-05-18 2001-07-11 Allergene Inc Composition
SE0102327D0 (sv) * 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
WO2003065010A2 (fr) * 2002-02-01 2003-08-07 University Of Maryland Identification d'epitopes sur des enterotoxines staphylococciques inhibant la transcytose
DE10207734A1 (de) * 2002-02-15 2003-09-04 Agelab Pharma Gmbh Immunmodulierendes Peptid aus S. aureus Enterotoxin B
WO2004087754A1 (fr) * 2003-04-03 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Antagonistes a large spectre efficaces in vivo de la toxine d'un superantigene reposant sur l'interaction entre la molecule cd28 et le superantigene, et utilisations correspondantes
US8535672B2 (en) 2002-04-04 2013-09-17 Yissum Research Development Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof
IL148993A0 (en) * 2002-04-04 2002-11-10 Yissum Res Dev Co Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof
JP4177031B2 (ja) * 2002-05-31 2008-11-05 富士通株式会社 通知方法及び通知装置
US7255867B2 (en) * 2002-11-15 2007-08-14 Id Biomedical Corporation Of Quebec Vaccine
WO2004072095A2 (fr) * 2003-02-12 2004-08-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Peptides cyclises en tant qu'antagonistes d'exotoxines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61178661A (ja) * 1985-02-05 1986-08-11 Toyobo Co Ltd エンテロトキシンの定量法
DE69024953T3 (de) * 1989-05-04 2005-01-27 Southern Research Institute, Birmingham Einkapselungsverfahren
DE69133485T2 (de) 1990-01-17 2006-06-22 Terman, David S., Pebble Beach Verwendung von Staphylococcus Enterotoxin Homologe für Krebs-Therapie
WO1991012818A1 (fr) 1990-02-23 1991-09-05 Immulogic Pharmaceutical Corporation Absence de faculte de reponse immune induite par superantigene
IT1244706B (it) * 1991-02-07 1994-08-08 Sclavo Spa Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici
US5310874A (en) * 1991-05-03 1994-05-10 The Scripps Research Institute Integrin α subunit cytoplasmic domain polypeptides and antibodies
US5545716A (en) 1992-09-08 1996-08-13 University Of Florida Superantigen agonist and antagonist peptides
US5705151A (en) * 1995-05-18 1998-01-06 National Jewish Center For Immunology & Respiratory Medicine Gene therapy for T cell regulation
WO1996040235A1 (fr) 1995-06-07 1996-12-19 Nexstar Pharmaceuticals, Inc. Procede d'utilisation de superantigenes pour cibler des sous-populations de lymphocytes t

Also Published As

Publication number Publication date
WO1998029444A1 (fr) 1998-07-09
AU7890998A (en) 1998-07-31
US7189398B2 (en) 2007-03-13
JP2001509014A (ja) 2001-07-10
US20020028211A1 (en) 2002-03-07
CA2276112A1 (fr) 1998-07-09
EP0952985A1 (fr) 1999-11-03
IL119938A0 (en) 1997-03-18

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