IL116559A - Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence - Google Patents

Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence

Info

Publication number
IL116559A
IL116559A IL11655995A IL11655995A IL116559A IL 116559 A IL116559 A IL 116559A IL 11655995 A IL11655995 A IL 11655995A IL 11655995 A IL11655995 A IL 11655995A IL 116559 A IL116559 A IL 116559A
Authority
IL
Israel
Prior art keywords
myelin basic
basic protein
mbp
moiety
amino acids
Prior art date
Application number
IL11655995A
Other languages
English (en)
Other versions
IL116559A0 (en
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11604495A external-priority patent/IL116044A0/xx
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11655995A priority Critical patent/IL116559A/xx
Publication of IL116559A0 publication Critical patent/IL116559A0/xx
Priority to DE69634263T priority patent/DE69634263T2/de
Priority to AT96937486T priority patent/ATE287963T1/de
Priority to KR1019980703699A priority patent/KR100530817B1/ko
Priority to PCT/IL1996/000151 priority patent/WO1997019179A1/fr
Priority to EP96937486A priority patent/EP0862637B1/fr
Priority to JP51956297A priority patent/JP3906447B2/ja
Priority to AU75040/96A priority patent/AU717617B2/en
Priority to CNB961994703A priority patent/CN1196791C/zh
Priority to US09/077,028 priority patent/US6531133B1/en
Publication of IL116559A publication Critical patent/IL116559A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL11655995A 1995-11-17 1995-12-26 Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence IL116559A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL11655995A IL116559A (en) 1995-11-17 1995-12-26 Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US09/077,028 US6531133B1 (en) 1995-11-17 1996-11-17 Pseudomonas exotoxin-myelin basic protein chimeric proteins
CNB961994703A CN1196791C (zh) 1995-11-17 1996-11-17 假单胞菌属外毒素－髓磷脂碱性蛋白嵌合蛋白
KR1019980703699A KR100530817B1 (ko) 1995-11-17 1996-11-17 슈도모나스 외독소-미에린염기성 단백질의 키메라 단백질
AT96937486T ATE287963T1 (de) 1995-11-17 1996-11-17 Pseudomonas exotoxin - myelin basisches protein chimäre proteine
DE69634263T DE69634263T2 (de) 1995-11-17 1996-11-17 Pseudomonas Exotoxin - Myelin basisches Protein Chimäre Proteine
PCT/IL1996/000151 WO1997019179A1 (fr) 1995-11-17 1996-11-17 Proteines chimeres a exotoxine de pseudomonas-proteine basique myelinique
EP96937486A EP0862637B1 (fr) 1995-11-17 1996-11-17 Proteines chimeres constituees de l' exotoxine de pseudomonas et de la proteine basique de la myeline
JP51956297A JP3906447B2 (ja) 1995-11-17 1996-11-17 シュードモナス外毒素−ミエリン塩基性蛋白質キメラ蛋白質
AU75040/96A AU717617B2 (en) 1995-11-17 1996-11-17 Pseudomonas exotoxin - myelin basic protein chimeric proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11604495A IL116044A0 (en) 1995-11-17 1995-11-17 Chimeric proteins
IL11655995A IL116559A (en) 1995-11-17 1995-12-26 Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence

Publications (2)

Publication Number Publication Date
IL116559A0 IL116559A0 (en) 1996-03-31
IL116559A true IL116559A (en) 2005-11-20

Family

ID=26323172

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11655995A IL116559A (en) 1995-11-17 1995-12-26 Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence

Country Status (10)

Country Link
US (1) US6531133B1 (fr)
EP (1) EP0862637B1 (fr)
JP (1) JP3906447B2 (fr)
KR (1) KR100530817B1 (fr)
CN (1) CN1196791C (fr)
AT (1) ATE287963T1 (fr)
AU (1) AU717617B2 (fr)
DE (1) DE69634263T2 (fr)
IL (1) IL116559A (fr)
WO (1) WO1997019179A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750329B1 (en) * 1989-05-05 2004-06-15 Research Development Foundation Antibody delivery system for biological response modifiers
US6252040B1 (en) * 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
IL116436A (en) 1995-12-18 2006-12-31 Yissum Res Dev Co Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND
ATE307208T1 (de) * 1997-07-11 2005-11-15 Us Gov Health & Human Serv Pseudomonas exotoxin-a-ähnliche chimerische immunogene
US20030054012A1 (en) * 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
US7314632B1 (en) 1997-07-11 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pseudomonas exotoxin A-like chimeric immunogens
US6645490B2 (en) 1998-03-02 2003-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2004535202A (ja) * 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
EP1572170A4 (fr) * 2002-06-12 2007-02-28 Res Dev Foundation Immunotoxine servant d'agent therapeutique et ses utilisations
WO2004096271A1 (fr) 2003-04-30 2004-11-11 Uwe Zangemeister-Wittke Procedes de traitement de cancer mettant en oeuvre une immunotoxine
EP1855724A2 (fr) * 2005-02-01 2007-11-21 Research Development Foundation Proteines de fusion blys (stimulatrices des lymphocytes b) pour cibler le recepteur blys et methodes pour le traitement des maladies proliferatives des cellules b
WO2011101870A1 (fr) * 2010-02-22 2011-08-25 Transgene Biotek Ltd. Protéines de fusion utilisées pour le traitement de la sclérose en plaques et d'autres maladies auto-immunes
CN102167732B (zh) * 2010-12-10 2013-08-21 厦门大学 蛋白类杀藻化合物及其制备方法
EP3456734B1 (fr) 2012-10-04 2022-01-05 Research Development Foundation Molécules de sérine protéase et thérapies
US11193117B2 (en) 2016-02-16 2021-12-07 Research Development Foundation Cell-targeted cytotoxic constructs
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
FR2521010B1 (fr) * 1982-02-09 1985-07-19 Sanofi Sa Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent
US5571500A (en) * 1987-06-24 1996-11-05 Autoimmune, Inc. Treatment of autoimmune diseases through administration by inhalation of autoantigens
US5869054A (en) * 1987-06-24 1999-02-09 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of autoantigens
US5571499A (en) * 1987-06-24 1996-11-05 Autoimmune, Inc. Treatment of autoimmune diseases by aerosol administration of autoantigens
US5849298A (en) * 1987-06-24 1998-12-15 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of bovine myelin
JP2849632B2 (ja) * 1988-04-08 1999-01-20 社団法人北里研究所 ワクチン製剤
US5468481A (en) * 1988-06-23 1995-11-21 Amergen, Inc. MHC class II-peptide conjugates useful in ameliorating autoimmunity
DK0469065T3 (da) 1989-04-21 1996-07-15 Protein Design Labs Inc Rekombinant antistof-toxin fusionsprotein
WO1991018018A1 (fr) * 1990-05-14 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Proteine chimerique pseudomonas amelioree presentant une cytotoxicite vis-a-vis de cellules humaines porteuses de recepteurs de il2
US5734023A (en) * 1991-11-19 1998-03-31 Anergen Inc. MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses
BR9306272A (pt) * 1992-04-09 1998-06-23 Autoimmune Inc Peptídeo e composiçao farmacêutica
US6045796A (en) * 1992-12-17 2000-04-04 Anergen, Inc. Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
US5763585A (en) * 1993-10-13 1998-06-09 Anergen, Inc. Method of making MHC-peptide complexes using metal chelate affinity chromatography
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US5759546A (en) * 1994-02-04 1998-06-02 Weinberg; Andrew D. Treatment of CD4 T-cell mediated conditions
US5935577A (en) * 1998-01-23 1999-08-10 Autoimmune Inc. Treatment of autoimmune disease using tolerization in combination with methotrexate

Also Published As

Publication number Publication date
JP3906447B2 (ja) 2007-04-18
KR100530817B1 (ko) 2006-01-27
EP0862637B1 (fr) 2005-01-26
IL116559A0 (en) 1996-03-31
AU717617B2 (en) 2000-03-30
DE69634263T2 (de) 2005-12-22
CN1207132A (zh) 1999-02-03
EP0862637A1 (fr) 1998-09-09
WO1997019179A1 (fr) 1997-05-29
US6531133B1 (en) 2003-03-11
JP2000513562A (ja) 2000-10-17
DE69634263D1 (en) 2005-03-03
ATE287963T1 (de) 2005-02-15
AU7504096A (en) 1997-06-11
CN1196791C (zh) 2005-04-13
KR19990067671A (ko) 1999-08-25

Similar Documents

Publication Publication Date Title
IL116559A (en) Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
Ooi et al. A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein.
HK1014030A1 (en) Cd2-binding domain of lymphocyte function associated antigen 3
DE69515613T2 (de) Immunogenes Hybridprotein OprF-Oprl erhältlich aus Membranproteinen von Pseudomonas aeruginosa
AU8635391A (en) Nucleotide sequences coding for a human protein with angiogenesis regulative properties
GR3030811T3 (en) Proteins produced by human lymphocytes, dna sequence coding these proteins, and pharmaceutical and biological uses thereof
GEP20022695B (en) Moraxella Catarrhalis Outer Membrane Protein-106 Polypeptide, Gene Sequence and Uses Thereof
MX9707061A (es) Proteina con superficie resistente de proteinase k de neisseria meningitidis.
EP0692031A4 (fr) Antigenes heterologues presents dans des souches vaccinales a cellules vivantes
GB9108652D0 (en) Immunoreactive compounds
CA2157925A1 (fr) Traitement de maladies mycobacteriennes par administration de produits proteiniques bactericides augmentant la permeabilite
Sauerborn et al. Nucleotide sequence of Clostridium difficile toxin A.
PT666914E (pt) Nova proteina ligando da selectina p
DE69634510T2 (de) Mutantes SPE-A-Toxin und dessen Verwendung
DK0494294T3 (da) Bakterielle stressproteiner
ATE121754T1 (de) Vakzine gegen bordetella.
MX9203138A (es) Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
AU2750092A (en) Synthetic peptide specificity of anti-myelin basic protein from multiple sclerosis cerebrospinal fluid
WO1997023624A3 (fr) Nouveaux polynucleotides et polypeptides dans des mycobacteries pathogenes et leur utilisation dans des diagnostics, des vaccins et des cibles de chimiotherapie
PT789764E (pt) Nova familia de inibidores de protease e outras substancias biologicas activas
EP0773290A3 (fr) Protéines analogues de récepteur à LDL et gènes codant pour celles-ci
Forestier et al. Afimbrial adhesin from Escherichia coli strain 2230: purification, characterization and partial covalent structure
AU5327198A (en) Nucleotide sequence coding for a flavin-containing monooxygenase, corresponding protein and their applications in the fields of diagnosis and therapy
AU692213B2 (en) Equine arteritis virus peptides, antibodies and their use in a diagnostic test
NZ505350A (en) DNA encoding a tumour antigen peptide (43 kDa) for diagnosis or treatment of tumours

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees