IL116477A - Bone graft substitute and process for producing same - Google Patents
Bone graft substitute and process for producing sameInfo
- Publication number
- IL116477A IL116477A IL11647795A IL11647795A IL116477A IL 116477 A IL116477 A IL 116477A IL 11647795 A IL11647795 A IL 11647795A IL 11647795 A IL11647795 A IL 11647795A IL 116477 A IL116477 A IL 116477A
- Authority
- IL
- Israel
- Prior art keywords
- bone graft
- graft substitute
- producing same
- tcp
- mixture
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Ceramic Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Structural Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11647795A IL116477A (en) | 1995-12-21 | 1995-12-21 | Bone graft substitute and process for producing same |
EP96940709A EP0868409B1 (de) | 1995-12-21 | 1996-12-19 | Ersatz für knochentransplantat und seine herstellung |
DE69615859T DE69615859T2 (de) | 1995-12-21 | 1996-12-19 | Ersatz für knochentransplantat und seine herstellung |
CA002237893A CA2237893A1 (en) | 1995-12-21 | 1996-12-19 | Bone graft substitute and its preparation |
AT96940709T ATE206696T1 (de) | 1995-12-21 | 1996-12-19 | Ersatz für knochentransplantat und seine herstellung |
US09/091,029 US6231607B1 (en) | 1995-12-21 | 1996-12-19 | Bone graft substitute and its preparation |
AU10708/97A AU718966B2 (en) | 1995-12-21 | 1996-12-19 | Bone graft substitute and its preparation |
PCT/IL1996/000182 WO1997023428A1 (en) | 1995-12-21 | 1996-12-19 | Bone graft substitute and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11647795A IL116477A (en) | 1995-12-21 | 1995-12-21 | Bone graft substitute and process for producing same |
Publications (2)
Publication Number | Publication Date |
---|---|
IL116477A0 IL116477A0 (en) | 1996-03-31 |
IL116477A true IL116477A (en) | 2000-02-29 |
Family
ID=11068341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11647795A IL116477A (en) | 1995-12-21 | 1995-12-21 | Bone graft substitute and process for producing same |
Country Status (8)
Country | Link |
---|---|
US (1) | US6231607B1 (de) |
EP (1) | EP0868409B1 (de) |
AT (1) | ATE206696T1 (de) |
AU (1) | AU718966B2 (de) |
CA (1) | CA2237893A1 (de) |
DE (1) | DE69615859T2 (de) |
IL (1) | IL116477A (de) |
WO (1) | WO1997023428A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003055418A1 (en) * | 2001-12-21 | 2003-07-10 | Lagow Richard J | Calcium phosphate bone replacement materials and methods of use thereof |
IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
IL153699A (en) | 2002-12-26 | 2008-11-26 | Prochon Biotech Ltd | The composition for transplantation basically |
JP3927487B2 (ja) * | 2002-12-02 | 2007-06-06 | 株式会社大野興業 | 人工骨モデルの製造方法 |
US20050010305A1 (en) * | 2003-01-28 | 2005-01-13 | Lee Francis Y. | Novel bone graft composite |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
WO2005120488A1 (en) * | 2004-06-10 | 2005-12-22 | Sara Sarig | Aspartic acid for the regeneration of bone matter |
US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20060198863A1 (en) * | 2005-03-03 | 2006-09-07 | Musculoskeletal Transplant Foundation | Ceramic composition for filling bone defects |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
US20080114468A1 (en) * | 2006-11-10 | 2008-05-15 | Biomet Manufacturing Corp. | Processes for making ceramic medical devices |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
SE531779C2 (sv) | 2007-11-26 | 2009-08-04 | Promimic Ab | Framställning av kalciumfosfatpartiklar i nanostorlek som pulver eller beläggning via bifunktionella prekursorer |
US20160059044A1 (en) | 2009-10-12 | 2016-03-03 | Kona Medical, Inc. | Energy delivery to intraparenchymal regions of the kidney to treat hypertension |
CN107296977B (zh) * | 2012-01-31 | 2021-03-23 | 托莱多大学 | 可注射的、生物可降解的骨接合剂及其制造和使用方法 |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI80605C (fi) * | 1986-11-03 | 1990-07-10 | Biocon Oy | Benkirurgisk biokompositmaterial. |
US4861733A (en) | 1987-02-13 | 1989-08-29 | Interpore International | Calcium phosphate bone substitute materials |
DD285240A7 (de) | 1988-09-27 | 1990-12-12 | Technisches Glas Veb K | Verfahren zur herstellung eines osteoinduktiven knochenersatzmaterials |
JP2621622B2 (ja) * | 1990-09-27 | 1997-06-18 | 三菱マテリアル株式会社 | 水硬性リン酸カルシウムセメント |
CA2143733A1 (en) | 1994-03-02 | 1995-09-03 | Yoshikazu Umezu | Alpha-tricalcium phosphate ceramic and production method thereof |
US5569442A (en) * | 1994-11-04 | 1996-10-29 | Norian Corporation | Reactive tricalcium phosphate compositions and uses |
AU3795395A (en) * | 1994-11-30 | 1996-06-06 | Ethicon Inc. | Hard tissue bone cements and substitutes |
-
1995
- 1995-12-21 IL IL11647795A patent/IL116477A/xx not_active IP Right Cessation
-
1996
- 1996-12-19 AT AT96940709T patent/ATE206696T1/de not_active IP Right Cessation
- 1996-12-19 DE DE69615859T patent/DE69615859T2/de not_active Expired - Fee Related
- 1996-12-19 CA CA002237893A patent/CA2237893A1/en not_active Abandoned
- 1996-12-19 AU AU10708/97A patent/AU718966B2/en not_active Ceased
- 1996-12-19 EP EP96940709A patent/EP0868409B1/de not_active Expired - Lifetime
- 1996-12-19 WO PCT/IL1996/000182 patent/WO1997023428A1/en active IP Right Grant
- 1996-12-19 US US09/091,029 patent/US6231607B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0868409A1 (de) | 1998-10-07 |
EP0868409B1 (de) | 2001-10-10 |
DE69615859D1 (de) | 2001-11-15 |
US6231607B1 (en) | 2001-05-15 |
AU718966B2 (en) | 2000-05-04 |
DE69615859T2 (de) | 2002-04-11 |
AU1070897A (en) | 1997-07-17 |
ATE206696T1 (de) | 2001-10-15 |
CA2237893A1 (en) | 1997-07-03 |
WO1997023428A1 (en) | 1997-07-03 |
EP0868409A4 (de) | 1998-12-02 |
IL116477A0 (en) | 1996-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |