IL112589A - Polysubstituted-3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives process and novel intermediates for their preparation and pharmaceutical compositions containing them - Google Patents

Polysubstituted-3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives process and novel intermediates for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112589A
IL112589A IL11258995A IL11258995A IL112589A IL 112589 A IL112589 A IL 112589A IL 11258995 A IL11258995 A IL 11258995A IL 11258995 A IL11258995 A IL 11258995A IL 112589 A IL112589 A IL 112589A
Authority
IL
Israel
Prior art keywords
benzodiazepin
polysubstituted
acylamino
phenyl
preparation
Prior art date
Application number
IL11258995A
Other languages
English (en)
Other versions
IL112589A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9401642A external-priority patent/FR2716194B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL112589A0 publication Critical patent/IL112589A0/xx
Publication of IL112589A publication Critical patent/IL112589A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL11258995A 1994-02-14 1995-02-09 Polysubstituted-3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives process and novel intermediates for their preparation and pharmaceutical compositions containing them IL112589A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9401642A FR2716194B1 (fr) 1994-02-14 1994-02-14 Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR9408665A FR2716195B1 (fr) 1994-02-14 1994-07-12 Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
IL112589A0 IL112589A0 (en) 1995-05-26
IL112589A true IL112589A (en) 2000-06-01

Family

ID=26230950

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11258995A IL112589A (en) 1994-02-14 1995-02-09 Polysubstituted-3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives process and novel intermediates for their preparation and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (2) US5719143A (de)
EP (1) EP0667344A1 (de)
JP (1) JPH07300467A (de)
KR (1) KR950032145A (de)
CN (1) CN1053438C (de)
AU (1) AU692202B2 (de)
CA (1) CA2142411A1 (de)
FI (1) FI950625A (de)
FR (1) FR2716195B1 (de)
HU (1) HUT70050A (de)
IL (1) IL112589A (de)
NO (1) NO307784B1 (de)
NZ (1) NZ270478A (de)
PL (1) PL179904B1 (de)
TW (1) TW427982B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9920872D0 (en) 1999-09-04 1999-11-10 Glaxo Group Ltd Benzophenones as inhibitors of reverse transcriptase
GB0011092D0 (en) * 2000-05-08 2000-06-28 Black James Foundation Gastrin and cholecystokinin receptor ligands (III)
US6713470B2 (en) * 2002-01-22 2004-03-30 Ml Laboratories Plc Method of treatment
US20040167146A1 (en) * 2002-01-22 2004-08-26 Karen Jackson Method of treatment
US20040043990A1 (en) * 2002-04-09 2004-03-04 Karen Jackson Method of treatment
JP4719466B2 (ja) * 2002-09-20 2011-07-06 アロー セラピューティクス リミテッド ベンゾジアゼピン誘導体およびそれらを含有する医薬組成物
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
ATE499903T1 (de) * 2004-03-18 2011-03-15 Contipi Ltd Gerät zur behandlung von organvorfall im weiblichen becken
JP4069159B2 (ja) * 2004-05-25 2008-04-02 ファイザー・プロダクツ・インク テトラアザベンゾ［ｅ］アズレン誘導体及びそれらのアナログ
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
CN102924448B (zh) * 2012-09-19 2015-02-25 渤海大学 生物碱cryptolepine类似物吲哚并喹啉酸化合物及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5023532B2 (de) * 1971-09-09 1975-08-08
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
NO950537D0 (no) 1995-02-13
HUT70050A (en) 1995-09-28
AU1166895A (en) 1995-08-24
US5798353A (en) 1998-08-25
JPH07300467A (ja) 1995-11-14
KR950032145A (ko) 1995-12-20
FR2716195A1 (fr) 1995-08-18
TW427982B (en) 2001-04-01
PL307255A1 (en) 1995-08-21
FI950625A0 (fi) 1995-02-13
IL112589A0 (en) 1995-05-26
CN1126207A (zh) 1996-07-10
NZ270478A (en) 1996-12-20
PL179904B1 (pl) 2000-11-30
FI950625A (fi) 1995-08-15
FR2716195B1 (fr) 1996-06-21
NO307784B1 (no) 2000-05-29
CN1053438C (zh) 2000-06-14
AU692202B2 (en) 1998-06-04
HU9500434D0 (en) 1995-03-28
NO950537L (no) 1995-08-15
CA2142411A1 (en) 1995-08-15
EP0667344A1 (de) 1995-08-16
US5719143A (en) 1998-02-17

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Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees