IL110932A - Difluororibosyl amines and azides and process for preparing the same - Google Patents

Difluororibosyl amines and azides and process for preparing the same

Info

Publication number
IL110932A
IL110932A IL11093294A IL11093294A IL110932A IL 110932 A IL110932 A IL 110932A IL 11093294 A IL11093294 A IL 11093294A IL 11093294 A IL11093294 A IL 11093294A IL 110932 A IL110932 A IL 110932A
Authority
IL
Israel
Prior art keywords
difluororibosyl
azides
amines
preparing
same
Prior art date
Application number
IL11093294A
Other languages
English (en)
Other versions
IL110932A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL110932A0 publication Critical patent/IL110932A0/xx
Priority to IL13724800A priority Critical patent/IL137248A0/xx
Publication of IL110932A publication Critical patent/IL110932A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Noodles (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL11093294A 1993-09-16 1994-09-12 Difluororibosyl amines and azides and process for preparing the same IL110932A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL13724800A IL137248A0 (en) 1993-09-16 2000-07-10 A process for the preparation of 2'-deoxy -2',2' difluoro ribozyl nucleosides and pharmaceutical compositions containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/122,876 US5480992A (en) 1993-09-16 1993-09-16 Anomeric fluororibosyl amines

Publications (2)

Publication Number Publication Date
IL110932A0 IL110932A0 (en) 1994-11-28
IL110932A true IL110932A (en) 2003-05-29

Family

ID=22405359

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11093294A IL110932A (en) 1993-09-16 1994-09-12 Difluororibosyl amines and azides and process for preparing the same
IL13724800A IL137248A0 (en) 1993-09-16 2000-07-10 A process for the preparation of 2'-deoxy -2',2' difluoro ribozyl nucleosides and pharmaceutical compositions containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL13724800A IL137248A0 (en) 1993-09-16 2000-07-10 A process for the preparation of 2'-deoxy -2',2' difluoro ribozyl nucleosides and pharmaceutical compositions containing the same

Country Status (15)

Country Link
US (3) US5480992A (cs)
EP (1) EP0647654B1 (cs)
JP (1) JP3762445B2 (cs)
KR (1) KR100322355B1 (cs)
AT (1) ATE186731T1 (cs)
BR (1) BR9403572A (cs)
CA (1) CA2130124C (cs)
DE (1) DE69421665T2 (cs)
DK (1) DK0647654T3 (cs)
ES (1) ES2139714T3 (cs)
FI (1) FI113179B (cs)
GR (1) GR3032603T3 (cs)
HU (1) HU220672B1 (cs)
IL (2) IL110932A (cs)
TW (1) TW342392B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6906495B2 (en) * 2002-05-13 2005-06-14 Splashpower Limited Contact-less power transfer
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2270235B1 (cs) * 1974-02-15 1982-09-03 Sanofi Sa
FR2315500A2 (fr) * 1975-06-24 1977-01-21 Labaz Procede de preparation d'un diazidocyclohexanediol
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4879377A (en) * 1983-11-18 1989-11-07 Bristol-Myers Company Nucleoside process
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類

Also Published As

Publication number Publication date
CA2130124C (en) 2004-08-10
HU9402646D0 (en) 1994-12-28
CA2130124A1 (en) 1995-03-17
HU220672B1 (hu) 2002-04-29
HUT72590A (en) 1996-05-28
JPH07149783A (ja) 1995-06-13
KR950008529A (ko) 1995-04-19
JP3762445B2 (ja) 2006-04-05
FI944281L (fi) 1995-03-17
DE69421665D1 (de) 1999-12-23
DK0647654T3 (da) 2000-03-13
US5541345A (en) 1996-07-30
ES2139714T3 (es) 2000-02-16
DE69421665T2 (de) 2000-05-25
EP0647654A3 (cs) 1995-05-03
KR100322355B1 (ko) 2002-11-30
US5480992A (en) 1996-01-02
FI944281A0 (fi) 1994-09-15
BR9403572A (pt) 1995-05-16
IL137248A0 (en) 2001-07-24
FI113179B (fi) 2004-03-15
EP0647654A2 (en) 1995-04-12
GR3032603T3 (en) 2000-05-31
TW342392B (en) 1998-10-11
US5594155A (en) 1997-01-14
ATE186731T1 (de) 1999-12-15
EP0647654B1 (en) 1999-11-17
IL110932A0 (en) 1994-11-28

Similar Documents

Publication Publication Date Title
EP0861827A3 (en) N-acyl-n,n'n'-ethylenediaminetriacetic acid derivatives and process for preparing the same
EP0636617A3 (de) Verfahren zur Herstellung von N-(2-Hydroxyethyl)-piperazin.
PL317127A1 (en) Novel derivatives of amino acids, method of obtaining them and pharmaceutic agents containing such derivatives
EP0676471A3 (en) Effector proteins for rapamycin.
EP0235967A3 (en) Pneumatically cushioned vehicle seat(s) and apparatus and method to adjust the same
AU6112790A (en) N-(substituted benzyloxy)imine derivatives, process for the production thereof, use thereof, and method of use thereof
EP1435352A3 (en) 9-[(Substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
EP0451953A3 (en) Process for the preparation of polyether amides from mixed amines
EP0678576A3 (en) Fructosyl amino acid oxidase and process for its preparation.
KR100222606B1 (en) Process for preparation of beta-lactams
AU4206197A (en) Process for simultaneously preparing 6-aminocapronitrile and hexamethylene diamine
MX9901061A (en) Process for producing amines and amino nitriles
CS335390A3 (en) Nonionic contrast means and process for preparing thereof
IL110932A (en) Difluororibosyl amines and azides and process for preparing the same
AU4300497A (en) Process for the manufacture of aliphatic alpha, omega amino nitriles
GR3029700T3 (en) Process for foaming acyloxysilane-containing silicone materials
EP0628536A3 (de) Verfahren zur Herstellung von Aminen.
PT80221A (en) Improved process for preparing benzamide derivatives useful as anticonvulsant agents
EP0410430A3 (en) Process for the microbiological discontinual preparation of l-carnitine
EP1134213A3 (en) Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides
AU7975394A (en) Process for preparing substituted aromatic amines
KR950011119B1 (en) Process for the manufacture of n,n-(di benzohexa trienylene)ureas
HU9300799D0 (en) Method for producing peptones and new intermediary compounds
WO1996016077A3 (en) Reagent for quantifying free amine groups
YU171188A (en) Process for preparing stable compounds from inputed chlorfluoralcane and amine and/or polyole, which contains amino groups

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees