IL110512A - History of diarylmethyl piperazine, their preparation and pharmaceutical preparations containing them - Google Patents
History of diarylmethyl piperazine, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL110512A IL110512A IL11051294A IL11051294A IL110512A IL 110512 A IL110512 A IL 110512A IL 11051294 A IL11051294 A IL 11051294A IL 11051294 A IL11051294 A IL 11051294A IL 110512 A IL110512 A IL 110512A
- Authority
- IL
- Israel
- Prior art keywords
- allyl
- dimethyl
- piperazinyl
- hydroxybenzyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9833393A | 1993-07-30 | 1993-07-30 | |
US16987993A | 1993-12-17 | 1993-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL110512A0 IL110512A0 (en) | 1994-10-21 |
IL110512A true IL110512A (en) | 1998-10-30 |
Family
ID=26794651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11051294A IL110512A (en) | 1993-07-30 | 1994-07-29 | History of diarylmethyl piperazine, their preparation and pharmaceutical preparations containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US5552404A (fr) |
EP (1) | EP0711289B1 (fr) |
JP (1) | JPH09501156A (fr) |
CN (1) | CN1054850C (fr) |
AT (1) | ATE195733T1 (fr) |
AU (1) | AU692788B2 (fr) |
CA (1) | CA2168432C (fr) |
DE (1) | DE69425662T2 (fr) |
DK (1) | DK0711289T3 (fr) |
ES (1) | ES2149881T3 (fr) |
GR (1) | GR3034695T3 (fr) |
HU (1) | HU221726B1 (fr) |
IL (1) | IL110512A (fr) |
MY (1) | MY111348A (fr) |
PT (1) | PT711289E (fr) |
RU (1) | RU2133744C1 (fr) |
TW (1) | TW386081B (fr) |
WO (1) | WO1995004051A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
US6410537B1 (en) * | 1994-09-09 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
SE9504662D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
US6359111B1 (en) | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
US6548637B1 (en) | 1998-06-18 | 2003-04-15 | Sepracor, Inc. | Ligands for opioid receptors |
SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
AU2001239896A1 (en) * | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0100764D0 (sv) | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
WO2002094794A1 (fr) | 2001-05-18 | 2002-11-28 | Astrazeneca Ab | Derives de 4(phenyl-piperazine-methyle) benzamide et utilisation de ces derives pour le traitement de la douleur, de l'anxiete ou des troubles gastro-intestinaux |
EP1450807B1 (fr) * | 2001-10-29 | 2013-12-25 | Versi Group, LLC | Procede de traitement de la depression avec des composes agonistes du recepteur delta |
AU2003214800A1 (en) * | 2002-01-02 | 2003-07-24 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
ES2298522T3 (es) | 2002-05-16 | 2008-05-16 | N.V. Organon | Combinacion sinergica de un analgesico opioide y un aine. |
CN1202843C (zh) * | 2002-06-21 | 2005-05-25 | 天大药业(深圳)有限公司 | 一种戒毒药物组合物及其制备方法和应用 |
WO2004007503A1 (fr) * | 2002-07-11 | 2004-01-22 | Toray Industries, Inc. | Agent therapeutique ou preventif pour la nausee/le vomissement |
EP1546837B1 (fr) * | 2002-09-27 | 2007-02-28 | Continental Teves AG & Co. oHG | Dispositif a pedale ajustable |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
TWI317286B (en) | 2003-12-31 | 2009-11-21 | Targeting delivery system | |
KR101234421B1 (ko) | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
US7683168B2 (en) * | 2005-04-14 | 2010-03-23 | Mount Cook Bio Sciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
EP2081562B1 (fr) | 2006-09-20 | 2016-02-24 | The Board of Regents of The University of Texas System | Procédé pour administrer des anesthésiants volatils pour une anesthésie locale et/ou le soulagement de la douleur |
JP5789100B2 (ja) | 2008-01-22 | 2015-10-07 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 抽出溶媒を含む、局部的な麻酔および/または疼痛低減のための揮発性麻酔薬組成物 |
BRPI0912756A2 (pt) * | 2008-05-20 | 2015-10-13 | Astrazeneca Ab | método para tratar transtorno depressivo maior ansioso em um animal de sangue quente, uso de um composto, composto, e, composição farmacêutica |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2630435A (en) * | 1948-09-09 | 1953-03-03 | Burroughs Wellcome Co | N-benzohydryl-n-methyl piperazines and process of preparing same |
US4518711A (en) | 1983-05-16 | 1985-05-21 | Gibson-Stephens Institute | Conformationally constrained cyclic enkephalin analogs with delta receptor specificity |
GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
IN163948B (fr) | 1986-01-17 | 1988-12-10 | Robins Co Inc A H | |
PH24752A (en) * | 1987-04-16 | 1990-10-01 | Lilly Co Eli | Piperidine opioid antagonists |
US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
DK0409406T3 (da) * | 1989-06-19 | 1994-02-07 | Wellcome Found | Arylsubstituerede aminderivater, der er anvendelige ved cancerterapi |
EP0458160A3 (en) | 1990-05-25 | 1992-03-18 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
SE467304B (sv) * | 1990-10-31 | 1992-06-29 | Kamewa Ab | Styr- och reverseringsanordning foer ett marint straaldriftsaggregat |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
-
1994
- 1994-07-29 CA CA002168432A patent/CA2168432C/fr not_active Expired - Fee Related
- 1994-07-29 JP JP7505665A patent/JPH09501156A/ja not_active Ceased
- 1994-07-29 CN CN94192949A patent/CN1054850C/zh not_active Expired - Fee Related
- 1994-07-29 AT AT94921756T patent/ATE195733T1/de not_active IP Right Cessation
- 1994-07-29 DE DE69425662T patent/DE69425662T2/de not_active Expired - Fee Related
- 1994-07-29 ES ES94921756T patent/ES2149881T3/es not_active Expired - Lifetime
- 1994-07-29 AU AU72351/94A patent/AU692788B2/en not_active Ceased
- 1994-07-29 IL IL11051294A patent/IL110512A/en not_active IP Right Cessation
- 1994-07-29 EP EP94921756A patent/EP0711289B1/fr not_active Expired - Lifetime
- 1994-07-29 WO PCT/GB1994/001641 patent/WO1995004051A1/fr active IP Right Grant
- 1994-07-29 PT PT94921756T patent/PT711289E/pt unknown
- 1994-07-29 DK DK94921756T patent/DK0711289T3/da active
- 1994-07-29 HU HU9501982A patent/HU221726B1/hu not_active IP Right Cessation
- 1994-07-29 RU RU96104351/04A patent/RU2133744C1/ru not_active IP Right Cessation
- 1994-07-29 MY MYPI94001988A patent/MY111348A/en unknown
- 1994-08-02 TW TW083107072A patent/TW386081B/zh not_active IP Right Cessation
-
1995
- 1995-04-28 US US08/431,377 patent/US5552404A/en not_active Expired - Lifetime
-
2000
- 2000-10-27 GR GR20000402382T patent/GR3034695T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2149881T3 (es) | 2000-11-16 |
GR3034695T3 (en) | 2001-01-31 |
PT711289E (pt) | 2001-02-28 |
EP0711289B1 (fr) | 2000-08-23 |
DE69425662T2 (de) | 2001-04-12 |
TW386081B (en) | 2000-04-01 |
EP0711289A1 (fr) | 1996-05-15 |
HU9501982D0 (en) | 1995-09-28 |
CN1054850C (zh) | 2000-07-26 |
US5552404A (en) | 1996-09-03 |
RU2133744C1 (ru) | 1999-07-27 |
CN1133593A (zh) | 1996-10-16 |
MY111348A (en) | 1999-11-30 |
DE69425662D1 (de) | 2000-09-28 |
AU692788B2 (en) | 1998-06-18 |
IL110512A0 (en) | 1994-10-21 |
CA2168432A1 (fr) | 1995-02-09 |
HUT72893A (en) | 1996-06-28 |
DK0711289T3 (da) | 2000-11-06 |
ATE195733T1 (de) | 2000-09-15 |
WO1995004051A1 (fr) | 1995-02-09 |
JPH09501156A (ja) | 1997-02-04 |
HU221726B1 (hu) | 2002-12-28 |
AU7235194A (en) | 1995-02-28 |
CA2168432C (fr) | 2004-03-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
HC | Change of name of proprietor(s) | ||
MM9K | Patent not in force due to non-payment of renewal fees |