IL109034A - Pharmaceutical preparations containing 3, 5 - diamino 6) 2, 3 dichlorophenyl (1, 2, 4 triazines for the treatment of impaired memory - Google Patents
Pharmaceutical preparations containing 3, 5 - diamino 6) 2, 3 dichlorophenyl (1, 2, 4 triazines for the treatment of impaired memoryInfo
- Publication number
- IL109034A IL109034A IL10903494A IL10903494A IL109034A IL 109034 A IL109034 A IL 109034A IL 10903494 A IL10903494 A IL 10903494A IL 10903494 A IL10903494 A IL 10903494A IL 109034 A IL109034 A IL 109034A
- Authority
- IL
- Israel
- Prior art keywords
- impaired memory
- dichlorophenyl
- learning disorder
- treatment
- triazine
- Prior art date
Links
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- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 208000024714 major depressive disease Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960002853 midazolam hydrochloride Drugs 0.000 description 1
- PLYSCVSCYOQVRP-UHFFFAOYSA-N midazolam hydrochloride Chemical compound Cl.C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F PLYSCVSCYOQVRP-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 210000000478 neocortex Anatomy 0.000 description 1
- 230000007121 neuropathological change Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000007474 nonparametric Mann- Whitney U test Methods 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960000770 ondansetron hydrochloride Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
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- 238000011552 rat model Methods 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305693A GB9305693D0 (en) | 1993-03-19 | 1993-03-19 | Therapeutic triazine compounds and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL109034A0 IL109034A0 (en) | 1994-06-24 |
| IL109034A true IL109034A (en) | 1998-12-06 |
Family
ID=10732358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10903494A IL109034A (en) | 1993-03-19 | 1994-03-18 | Pharmaceutical preparations containing 3, 5 - diamino 6) 2, 3 dichlorophenyl (1, 2, 4 triazines for the treatment of impaired memory |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0689439B1 (enEXAMPLES) |
| JP (1) | JPH08507782A (enEXAMPLES) |
| AP (1) | AP478A (enEXAMPLES) |
| AT (1) | ATE198831T1 (enEXAMPLES) |
| AU (1) | AU6217694A (enEXAMPLES) |
| DE (1) | DE69426622T2 (enEXAMPLES) |
| DK (1) | DK0689439T3 (enEXAMPLES) |
| ES (1) | ES2153854T3 (enEXAMPLES) |
| GB (1) | GB9305693D0 (enEXAMPLES) |
| GR (1) | GR3035528T3 (enEXAMPLES) |
| IL (1) | IL109034A (enEXAMPLES) |
| PT (1) | PT689439E (enEXAMPLES) |
| TW (1) | TW256773B (enEXAMPLES) |
| WO (1) | WO1994021260A1 (enEXAMPLES) |
| ZA (1) | ZA941938B (enEXAMPLES) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9424766D0 (en) * | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
| DE19603984A1 (de) * | 1996-02-05 | 1997-08-07 | Bayer Ag | Granulate von Triazinen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW12980A1 (en) * | 1979-06-01 | 1982-01-06 | Wellcome Found | Substituted aromatic compounds |
| GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
| JP2632754B2 (ja) * | 1991-05-21 | 1997-07-23 | 塩野義製薬株式会社 | 脳内グルタミン酸遊離抑制剤 |
-
1993
- 1993-03-19 GB GB939305693A patent/GB9305693D0/en active Pending
-
1994
- 1994-03-18 EP EP94909263A patent/EP0689439B1/en not_active Expired - Lifetime
- 1994-03-18 AT AT94909263T patent/ATE198831T1/de not_active IP Right Cessation
- 1994-03-18 ES ES94909263T patent/ES2153854T3/es not_active Expired - Lifetime
- 1994-03-18 DK DK94909263T patent/DK0689439T3/da active
- 1994-03-18 AP APAP/P/1994/000627A patent/AP478A/en active
- 1994-03-18 WO PCT/GB1994/000559 patent/WO1994021260A1/en active IP Right Grant
- 1994-03-18 AU AU62176/94A patent/AU6217694A/en not_active Abandoned
- 1994-03-18 TW TW083102373A patent/TW256773B/zh active
- 1994-03-18 ZA ZA941938A patent/ZA941938B/xx unknown
- 1994-03-18 IL IL10903494A patent/IL109034A/en active IP Right Grant
- 1994-03-18 DE DE69426622T patent/DE69426622T2/de not_active Expired - Fee Related
- 1994-03-18 JP JP6520807A patent/JPH08507782A/ja not_active Ceased
- 1994-03-18 PT PT94909263T patent/PT689439E/pt unknown
-
2001
- 2001-03-08 GR GR20010400367T patent/GR3035528T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AP9400627A0 (en) | 1994-04-30 |
| ES2153854T3 (es) | 2001-03-16 |
| WO1994021260A1 (en) | 1994-09-29 |
| TW256773B (enEXAMPLES) | 1995-09-11 |
| PT689439E (pt) | 2001-05-31 |
| GB9305693D0 (en) | 1993-05-05 |
| AP478A (en) | 1996-03-08 |
| DE69426622D1 (de) | 2001-03-01 |
| DK0689439T3 (da) | 2001-04-17 |
| IL109034A0 (en) | 1994-06-24 |
| JPH08507782A (ja) | 1996-08-20 |
| ATE198831T1 (de) | 2001-02-15 |
| GR3035528T3 (en) | 2001-06-29 |
| EP0689439B1 (en) | 2001-01-24 |
| DE69426622T2 (de) | 2001-06-21 |
| AU6217694A (en) | 1994-10-11 |
| EP0689439A1 (en) | 1996-01-03 |
| ZA941938B (en) | 1995-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |