IL108836A - C9 taxane derivatives and pharmaceutical compositions containing them - Google Patents
C9 taxane derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL108836A IL108836A IL10883694A IL10883694A IL108836A IL 108836 A IL108836 A IL 108836A IL 10883694 A IL10883694 A IL 10883694A IL 10883694 A IL10883694 A IL 10883694A IL 108836 A IL108836 A IL 108836A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- taxane derivatives
- substituents
- taxane
- Prior art date
Links
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000000063 antileukemic agent Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/026,978 US5990325A (en) | 1993-03-05 | 1993-03-05 | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
| US3485293A | 1993-03-22 | 1993-03-22 | |
| US9508793A | 1993-07-20 | 1993-07-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL108836A0 IL108836A0 (en) | 1994-06-24 |
| IL108836A true IL108836A (en) | 2005-11-20 |
Family
ID=27362899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10883694A IL108836A (en) | 1993-03-05 | 1994-03-03 | C9 taxane derivatives and pharmaceutical compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1148055A1 (da) |
| JP (1) | JP3892480B2 (da) |
| AT (1) | ATE218858T1 (da) |
| AU (1) | AU686137B2 (da) |
| DE (1) | DE69430797T2 (da) |
| DK (1) | DK0688212T3 (da) |
| ES (1) | ES2179070T3 (da) |
| IL (1) | IL108836A (da) |
| PT (1) | PT688212E (da) |
| WO (1) | WO1994020088A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710287A (en) | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
| US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
| CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
| SI1664033T1 (sl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh |
| CA2539975C (en) * | 2003-09-25 | 2012-11-20 | Tapestry Pharmaceuticals, Inc. | 9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof |
| CN100516067C (zh) | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
-
1994
- 1994-03-01 DE DE69430797T patent/DE69430797T2/de not_active Expired - Fee Related
- 1994-03-01 WO PCT/US1994/002210 patent/WO1994020088A1/en active IP Right Grant
- 1994-03-01 JP JP52011194A patent/JP3892480B2/ja not_active Expired - Fee Related
- 1994-03-01 EP EP01118414A patent/EP1148055A1/en not_active Withdrawn
- 1994-03-01 EP EP94909840A patent/EP0688212B1/en not_active Expired - Lifetime
- 1994-03-01 AU AU62525/94A patent/AU686137B2/en not_active Ceased
- 1994-03-01 DK DK94909840T patent/DK0688212T3/da active
- 1994-03-01 ES ES94909840T patent/ES2179070T3/es not_active Expired - Lifetime
- 1994-03-01 PT PT94909840T patent/PT688212E/pt unknown
- 1994-03-01 AT AT94909840T patent/ATE218858T1/de not_active IP Right Cessation
- 1994-03-03 IL IL10883694A patent/IL108836A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL108836A0 (en) | 1994-06-24 |
| ES2179070T3 (es) | 2003-01-16 |
| AU686137B2 (en) | 1998-02-05 |
| ATE218858T1 (de) | 2002-06-15 |
| WO1994020088A1 (en) | 1994-09-15 |
| EP0688212B1 (en) | 2002-06-12 |
| DK0688212T3 (da) | 2002-10-07 |
| EP1148055A1 (en) | 2001-10-24 |
| DE69430797T2 (de) | 2003-02-27 |
| EP0688212A4 (en) | 1996-03-20 |
| JP3892480B2 (ja) | 2007-03-14 |
| PT688212E (pt) | 2002-11-29 |
| JPH08507309A (ja) | 1996-08-06 |
| DE69430797D1 (de) | 2002-07-18 |
| EP0688212A1 (en) | 1995-12-27 |
| AU6252594A (en) | 1994-09-26 |
| MX9401623A (es) | 1997-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |