IL107347A0 - Neuroprotective 3,4-dihydro-2 (1h)-quinolone compounds - Google Patents

Neuroprotective 3,4-dihydro-2 (1h)-quinolone compounds

Info

Publication number
IL107347A0
IL107347A0 IL107347A IL10734793A IL107347A0 IL 107347 A0 IL107347 A0 IL 107347A0 IL 107347 A IL107347 A IL 107347A IL 10734793 A IL10734793 A IL 10734793A IL 107347 A0 IL107347 A0 IL 107347A0
Authority
IL
Israel
Prior art keywords
pct
fluoro atoms
compounds
neuroprotective
dihydro
Prior art date
Application number
IL107347A
Other languages
English (en)
Original Assignee
Pfize Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfize Inc filed Critical Pfize Inc
Publication of IL107347A0 publication Critical patent/IL107347A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL107347A 1992-10-30 1993-10-21 Neuroprotective 3,4-dihydro-2 (1h)-quinolone compounds IL107347A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96964292A 1992-10-30 1992-10-30

Publications (1)

Publication Number Publication Date
IL107347A0 true IL107347A0 (en) 1994-01-25

Family

ID=25515803

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107347A IL107347A0 (en) 1992-10-30 1993-10-21 Neuroprotective 3,4-dihydro-2 (1h)-quinolone compounds

Country Status (25)

Country Link
US (1) US5852040A (xx)
EP (1) EP0666854B1 (xx)
JP (1) JP2695292B2 (xx)
KR (1) KR950704298A (xx)
CN (1) CN1039644C (xx)
AT (1) ATE150751T1 (xx)
AU (1) AU669206B2 (xx)
BR (1) BR9307331A (xx)
CA (1) CA2146260C (xx)
CZ (1) CZ280669B6 (xx)
DE (1) DE69309297T2 (xx)
DK (1) DK0666854T3 (xx)
ES (1) ES2099969T3 (xx)
FI (1) FI934800A (xx)
GR (1) GR3023264T3 (xx)
HU (1) HUT65472A (xx)
IL (1) IL107347A0 (xx)
MX (1) MX9306796A (xx)
MY (1) MY109684A (xx)
NO (1) NO951631L (xx)
NZ (1) NZ255074A (xx)
PL (1) PL173618B1 (xx)
TW (1) TW299231B (xx)
WO (1) WO1994010166A1 (xx)
ZA (1) ZA938091B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
US6200990B1 (en) 1998-12-21 2001-03-13 Alcon Laboratories, Inc. Neuroprotective agents having antioxidant and NMDA antagonist activity
KR20010069066A (ko) * 2000-01-12 2001-07-23 이종원 저산소 농도하에서 생존이 가능하도록 하는 동물세포의배양방법
US6713490B2 (en) * 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
MXPA06003748A (es) * 2003-10-08 2006-06-14 Pfizer Compuestos de lactama condensada.
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
CN103664798A (zh) * 2012-09-20 2014-03-26 杨育新 一类治疗创伤性脑损伤疾病的化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5733M (xx) * 1966-09-27 1968-01-22
JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
EP0322361A3 (de) * 1987-12-23 1990-01-24 Ciba-Geigy Ag Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
US5506231A (en) * 1989-03-31 1996-04-09 The Children's Medical Center Corporation Treatment of aids dementia, myelopathy and blindness
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
BR9106432A (pt) * 1990-05-10 1993-05-04 Pfizer Indolona neuroprotetora e derivados correlatos
EP0524846A1 (fr) * 1991-06-27 1993-01-27 Synthelabo Dérivés de 2-(pipéridin-1-y1) éthanol, leur préparation et leur application en thérapeutique
AU655840B2 (en) * 1991-07-17 1995-01-12 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives

Also Published As

Publication number Publication date
WO1994010166A1 (en) 1994-05-11
MX9306796A (es) 1994-04-29
AU4778093A (en) 1994-05-24
PL173618B1 (pl) 1998-04-30
EP0666854A1 (en) 1995-08-16
CN1039644C (zh) 1998-09-02
GR3023264T3 (en) 1997-07-30
FI934800A0 (fi) 1993-10-29
MY109684A (en) 1997-04-30
PL308667A1 (en) 1995-08-21
EP0666854B1 (en) 1997-03-26
CZ111095A3 (en) 1995-11-15
FI934800A (fi) 1994-05-01
ATE150751T1 (de) 1997-04-15
BR9307331A (pt) 1999-05-25
NO951631D0 (no) 1995-04-28
CN1095719A (zh) 1994-11-30
CZ280669B6 (cs) 1996-03-13
KR950704298A (ko) 1995-11-17
JP2695292B2 (ja) 1997-12-24
JPH07508756A (ja) 1995-09-28
CA2146260C (en) 1998-04-07
ES2099969T3 (es) 1997-06-01
HUT65472A (en) 1994-06-28
TW299231B (xx) 1997-03-01
CA2146260A1 (en) 1994-05-11
ZA938091B (en) 1995-05-02
US5852040A (en) 1998-12-22
AU669206B2 (en) 1996-05-30
DE69309297D1 (de) 1997-04-30
DK0666854T3 (da) 1997-04-28
HU9303082D0 (en) 1994-01-28
DE69309297T2 (de) 1997-07-03
NO951631L (no) 1995-04-28
NZ255074A (en) 1996-10-28

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