IL104024A - 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them - Google Patents

4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them

Info

Publication number
IL104024A
IL104024A IL104024A IL10402492A IL104024A IL 104024 A IL104024 A IL 104024A IL 104024 A IL104024 A IL 104024A IL 10402492 A IL10402492 A IL 10402492A IL 104024 A IL104024 A IL 104024A
Authority
IL
Israel
Prior art keywords
lower alkyl
hydrogen
antimigraine
indol
pyrimidinyl
Prior art date
Application number
IL104024A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL104024A publication Critical patent/IL104024A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IL104024A 1991-12-19 1992-12-08 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them IL104024A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81066191A 1991-12-19 1991-12-19
US95959292A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
IL104024A true IL104024A (en) 1997-04-15

Family

ID=27123378

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104024A IL104024A (en) 1991-12-19 1992-12-08 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them

Country Status (15)

Country Link
US (1) US5434154A (fr)
EP (1) EP0548813A1 (fr)
JP (1) JPH05262762A (fr)
CN (1) CN1085556A (fr)
AU (1) AU661527B2 (fr)
CA (1) CA2084531A1 (fr)
CZ (1) CZ359292A3 (fr)
FI (1) FI925737A (fr)
IL (1) IL104024A (fr)
MX (1) MX9207114A (fr)
NO (1) NO302522B1 (fr)
NZ (1) NZ245439A (fr)
PH (1) PH30988A (fr)
RU (1) RU2114111C1 (fr)
TW (1) TW221420B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
CA2130078A1 (fr) * 1993-09-16 1995-03-17 Jonas A. Gylys Derives cyclobutenediones de l'indolylakylpyridinyle et des pyrimidinylpiperazines ayant des proprietes antimigraineuses
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5552402A (en) * 1994-05-19 1996-09-03 Merck, Sharp & Dohme Ltd. Five-membered heteroaromatic compounds as 5-HT receptor agonists
US5807857A (en) * 1994-05-19 1998-09-15 Merck Sharp & Dohme Ltd. Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
US5567824A (en) * 1994-05-24 1996-10-22 Merck & Co., Inc. Palladium catalyzed ring closure of triazolyltryptamine
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
US5550239A (en) * 1994-11-08 1996-08-27 Bristol-Myers Squibb Company Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
WO1997006159A1 (fr) * 1995-08-07 1997-02-20 Merck Sharp & Dohme Limited Derives de 1-indolylpropyl-4-phenethylpiperazine substitues
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
GB9519563D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
JP2000501070A (ja) * 1995-09-28 2000-02-02 メルク シヤープ エンド ドーム リミテツド ５−ＨＴ▲下１Ｄα▼アゴニストとしての置換インドリルプロピルピペラジン誘導体
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
DE19756036A1 (de) 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
EP1341777B1 (fr) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine, ses sels acceptables sur le plan pharmaceutique et ses solvants
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US7407983B2 (en) 2002-02-13 2008-08-05 Meiji Dairies Corporation Indole derivatives substituted with long-chain alcohols and medicaments containing them
WO2006129190A1 (fr) * 2005-06-03 2006-12-07 Glenmark Pharmaceuticals Limited Procede de preparation de l'almotriptan
RU2461556C2 (ru) * 2006-12-30 2012-09-20 Эбботт Гмбх Унд Ко. Кг Замещенные производные оксидола и их применение в качестве лигандов рецептора вазопрессина
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
EP2036888A1 (fr) * 2007-09-17 2009-03-18 Laboratorios del Dr. Esteve S.A. Sulfonamides à substitution naphtyl
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
EP3027607B1 (fr) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryliques substitués et procédés d'utilisation
WO2015090235A1 (fr) * 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Composés pipéraziniques substitués et leurs procédés d'utilisation
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
EP3700908A1 (fr) * 2017-10-27 2020-09-02 Fresenius Kabi Oncology Ltd Procédé amélioré pour la préparation de ribociclib et de ses sels

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (fr) * 1959-09-25 1900-01-01
GB1189064A (en) 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
GR79215B (fr) 1982-06-07 1984-10-22 Glaxo Group Ltd
GB2162522B (en) 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
JP2871811B2 (ja) 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
US5077293A (en) 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (fr) * 1990-06-29 2002-01-22 David W. Smith Derives pour combattre la migraine d'alcoxypirimidine

Also Published As

Publication number Publication date
PH30988A (en) 1997-12-23
NZ245439A (en) 1995-07-26
FI925737A (fi) 1993-06-20
US5434154A (en) 1995-07-18
JPH05262762A (ja) 1993-10-12
EP0548813A1 (fr) 1993-06-30
CZ359292A3 (en) 1994-01-19
AU661527B2 (en) 1995-07-27
NO924764D0 (no) 1992-12-10
NO924764L (no) 1993-06-21
AU3003492A (en) 1994-03-24
MX9207114A (es) 1993-07-01
RU2114111C1 (ru) 1998-06-27
FI925737A0 (fi) 1992-12-17
TW221420B (fr) 1994-03-01
NO302522B1 (no) 1998-03-16
CA2084531A1 (fr) 1993-06-20
CN1085556A (zh) 1994-04-20

Similar Documents

Publication Publication Date Title
IL104024A (en) 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them
ES8305356A1 (es) Un procedimiento para la produccion de un derivado de carbostirilo
GR75353B (fr)
SE8201854L (sv) N-substituerade amino-aminosyror
ES8401466A1 (es) Procedimiento para la obtencion de derivados de piridina.
IL103944A (en) Piperazine derivatives, their preparation and pharmaceutical compositions containing them
IL105372A0 (en) 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutical compositions containing them
EP0353955A3 (fr) Composés chimiques
PL322733A1 (en) Benzimidazole containing pharmaceutic agent useful in inhibiting development of carcinoma
IL107961A0 (en) Phenoxy- and phenoxyalkyl-piperidines and pharmaceutical compositions containing them
ES481729A1 (es) Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
EP0614661A3 (fr) Dérivés de la benzylidène et la cinnamylidène-Malononitrile pour l'inhibition des processus de prolifération dans les cellules des mammifères.
TW375615B (en) Galanthamine derivatives and their use as medicaments
IL108259A0 (en) Piperazine derivates, their preparation and pharmaceutical compositions containing them
ES8306142A1 (es) "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas".
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
ES2019163A6 (es) Procedimiento para preparar derivados de imidazol.
MY129935A (en) Dihydropyridine derivatives useful in antitumor therapy
AU579116B2 (en) Use of quinoline derivatives for the protection of cultivated plants
MY103502A (en) Novel compounds
IL102409A0 (en) Mono and bis alkylamino-anthracyclines,their preparation and pharmaceutical compositions containing them
AP1518A (en) Novel octahydro-6, 10-dioxo-6h-pyridazino/1,2-a/ /1,2/diazepin-1-carboxylic acid derivatives, preparation method and use for preparing therapeutically active compounds.
ES2003086A6 (es) Procedimiento de obtencion de tienoquinolicinsulfonamidas
IL115085A (en) Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void