IL102621A0 - Activator gene for macrolide biosynthesis - Google Patents

Activator gene for macrolide biosynthesis

Info

Publication number
IL102621A0
IL102621A0 IL102621A IL10262192A IL102621A0 IL 102621 A0 IL102621 A0 IL 102621A0 IL 102621 A IL102621 A IL 102621A IL 10262192 A IL10262192 A IL 10262192A IL 102621 A0 IL102621 A0 IL 102621A0
Authority
IL
Israel
Prior art keywords
activator gene
macrolide biosynthesis
macrolide
biosynthesis
activator
Prior art date
Application number
IL102621A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL102621A0 publication Critical patent/IL102621A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1292—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL102621A 1991-07-26 1992-07-23 Activator gene for macrolide biosynthesis IL102621A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/736,178 US5514544A (en) 1991-07-26 1991-07-26 Activator gene for macrolide biosynthesis

Publications (1)

Publication Number Publication Date
IL102621A0 true IL102621A0 (en) 1993-01-14

Family

ID=24958826

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102621A IL102621A0 (en) 1991-07-26 1992-07-23 Activator gene for macrolide biosynthesis

Country Status (9)

Country Link
US (1) US5514544A (xx)
EP (1) EP0524832A3 (xx)
JP (1) JPH05317053A (xx)
AU (1) AU2052492A (xx)
CA (1) CA2074547A1 (xx)
HU (1) HUT62332A (xx)
IE (1) IE922435A1 (xx)
IL (1) IL102621A0 (xx)
MX (1) MX9204375A (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40596E1 (en) * 1993-04-08 2008-12-02 Novartis Ag Rapamycin assay
GB9307491D0 (en) * 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
NZ313383A (en) * 1995-07-06 1999-08-30 Univ Leland Stanford Junior Cell-free synthesis of polyketides using pks (polyketide synthase)
WO1997022711A1 (en) 1995-12-19 1997-06-26 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6677135B1 (en) * 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
US6902913B2 (en) * 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6117659A (en) 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US5976836A (en) * 1997-05-07 1999-11-02 Fermalogic, Inc. Methods and compositions for enhancing erythromycin production
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
JP2002528467A (ja) 1998-10-28 2002-09-03 コーサン バイオサイエンシーズ， インコーポレイテッド 新規な「不自然な（ｕｎｎａｔｕｒａｌ）」天然生成物のライブラリ
JP2002536014A (ja) 1999-02-09 2002-10-29 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ ポリケチドシンターゼモジュールの有効性を媒介する方法
US7001748B2 (en) * 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
AU2003213757A1 (en) * 2002-03-04 2003-09-22 Brown University Research Foundation Methods to mediate polyketide synthase module effectiveness
EP1905833B1 (fr) 2002-10-08 2015-08-12 Aventis Pharma S.A. Polypeptides impliqués dans la biosynthèse des spiramycines, séquences nucléotidiques codant ces polypeptides et leurs applications
WO2004033689A2 (fr) * 2002-10-08 2004-04-22 Aventis Pharma S.A. Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications.
US7579167B2 (en) 2002-10-08 2009-08-25 Aventis Pharma S. Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
FR2599743B1 (fr) * 1986-06-10 1988-09-30 Pasteur Institut Fragment d'adn comprenant au moins une partie d'un gene de resistance a l'erythromycine, son procede d'obtention et ses applications biochimiques
CA1307482C (en) * 1987-11-09 1992-09-15 Ronald G. Schoner Vectors and expression sequences for production of polypeptides
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms

Also Published As

Publication number Publication date
CA2074547A1 (en) 1993-01-27
IE922435A1 (en) 1993-01-27
AU2052492A (en) 1993-01-28
EP0524832A3 (en) 1993-12-08
HU9202420D0 (en) 1992-10-28
HUT62332A (en) 1993-04-28
EP0524832A2 (en) 1993-01-27
MX9204375A (es) 1993-01-01
JPH05317053A (ja) 1993-12-03
US5514544A (en) 1996-05-07

Similar Documents

Publication Publication Date Title
EP0524832A3 (en) Activator gene for macrolide biosynthesis
HK1011278A1 (en) Macrolide formulations
HU9303093D0 (en) Enzyme systhems
GB9300456D0 (en) Antibiotic compounds
AU121011S (en) Pantiliner
GB9306386D0 (en) Gene expression
AU3901393A (en) Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9304156D0 (en) Antibiotic compounds
GB9313555D0 (en) Methylating enzyme from streptomyces ma6858
AU7394394A (en) 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
GB9107342D0 (en) Antibiotic compounds
EP0668289A4 (en) NEW DISACCHARIDE DERIVATIVE.
IL154162A0 (en) Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL115312A0 (en) Antibiotic macrolides
GB9108354D0 (en) Nucleotide probes
ZA926834B (en) Antibiotic LL-E19020 Gamma.
EP0748869A4 (en) ECTOINE SYNTHETASE GENE
EP0459525A3 (en) Genes encoding a 3-acylation enzyme for macrolide antibiotics
AU2269192A (en) System for controlled nitriding
AU2387292A (en) Antisense oligonucleotides
ZA922761B (en) Gene expression cassette
AU1436292A (en) Transglutaminase enzyme inhibitors
HU9401467D0 (en) 7-amino-naphthazarin antibiotic derivatives
GB9112798D0 (en) Nucleotides
GB9117069D0 (en) Nucleotides