IL102486A - Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe - Google Patents

Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe

Info

Publication number
IL102486A
IL102486A IL102486A IL10248692A IL102486A IL 102486 A IL102486 A IL 102486A IL 102486 A IL102486 A IL 102486A IL 10248692 A IL10248692 A IL 10248692A IL 102486 A IL102486 A IL 102486A
Authority
IL
Israel
Prior art keywords
nucleic acid
detection
acid sequences
molecules
acid probe
Prior art date
Application number
IL102486A
Other languages
English (en)
Inventor
Avraham Reinhartz
Sara Aladjem
Max Herzberg
Original Assignee
Orgenics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26322329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL102486(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL99647A external-priority patent/IL99647A/xx
Application filed by Orgenics Ltd filed Critical Orgenics Ltd
Priority to IL102486A priority Critical patent/IL102486A/xx
Priority to DE69216640T priority patent/DE69216640T2/de
Priority to PCT/NL1992/000176 priority patent/WO1993007292A1/en
Priority to EP92921614A priority patent/EP0612354B1/en
Priority to JP5506805A priority patent/JPH07501933A/ja
Priority to AU27894/92A priority patent/AU2789492A/en
Priority to AT92921614T priority patent/ATE147440T1/de
Priority to US08/306,254 priority patent/US5527673A/en
Publication of IL102486A publication Critical patent/IL102486A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL102486A 1991-10-04 1992-07-13 Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe IL102486A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL102486A IL102486A (en) 1991-10-04 1992-07-13 Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe
DE69216640T DE69216640T2 (de) 1991-10-04 1992-10-05 Verfahren und Gerät zum Nachweis von Nukleinsäurensequenzen.
PCT/NL1992/000176 WO1993007292A1 (en) 1991-10-04 1992-10-05 Method and apparatus for detection of nucleic acid sequences
EP92921614A EP0612354B1 (en) 1991-10-04 1992-10-05 Method and apparatus for detection of nucleic acid sequences
JP5506805A JPH07501933A (ja) 1991-10-04 1992-10-05 核酸配列の検出のための方法及び装置
AU27894/92A AU2789492A (en) 1991-10-04 1992-10-05 Method and apparatus for detection of nucleic acid sequences
AT92921614T ATE147440T1 (de) 1991-10-04 1992-10-05 Verfahren und gerät zum nachweis von nukleinsäurensequenzen.
US08/306,254 US5527673A (en) 1991-10-04 1994-09-14 Apparatus and method for transport of nucleic acid sequences by capillary action on a solid support and detection of the nucleic acid sequences

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL99647A IL99647A (en) 1991-10-04 1991-10-04 Method and apparatus for detection of nucleic acid sequences
IL102486A IL102486A (en) 1991-10-04 1992-07-13 Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe

Publications (1)

Publication Number Publication Date
IL102486A true IL102486A (en) 1997-11-20

Family

ID=26322329

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102486A IL102486A (en) 1991-10-04 1992-07-13 Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe

Country Status (8)

Country Link
US (1) US5527673A (ja)
EP (1) EP0612354B1 (ja)
JP (1) JPH07501933A (ja)
AT (1) ATE147440T1 (ja)
AU (1) AU2789492A (ja)
DE (1) DE69216640T2 (ja)
IL (1) IL102486A (ja)
WO (1) WO1993007292A1 (ja)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US5756126A (en) * 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
US5985327A (en) 1988-10-05 1999-11-16 Flinders Technologies Pty. Ltd. Solid medium and method for DNA storage
US6447804B1 (en) 1988-10-05 2002-09-10 Whatman, Plc Dry solid medium for storage and analysis of genetic material
US5972386A (en) * 1995-12-19 1999-10-26 Flinders Technologies Pty, Ltd. Dry solid medium for storage and analysis of genetic material
US5807527A (en) * 1991-05-29 1998-09-15 Flinders Technologies Pty. Ltd. Solid medium and method for DNA storage
IL108159A (en) * 1993-12-23 1998-02-08 Orgenics Ltd Apparatus for separation, concentration and detection of target molecules in liquid sample
US6037127A (en) * 1994-03-31 2000-03-14 E. I. Du Pont De Nemours And Company Method for detection of non-denatured nucleic acid fragments
WO1995027081A1 (en) * 1994-03-31 1995-10-12 E.I. Du Pont De Nemours And Company A method for detection of nucleic acid fragments
SE9402518D0 (sv) * 1994-07-18 1994-07-18 Pharmacia Biotech Ab Processing system
AU691114B2 (en) * 1995-06-07 1998-05-07 Whatman Plc Dry solid medium for storage and analysis of genetic material
US6153425A (en) * 1995-07-13 2000-11-28 Xtrana, Inc. Self-contained device integrating nucleic acid extraction, amplification and detection
US5989813A (en) * 1995-07-13 1999-11-23 Molecular Innovations, Inc. Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles
WO1997003348A1 (en) * 1995-07-13 1997-01-30 Immunological Associates Of Denver Self-contained device integrating nucleic acid extraction, amplification and detection
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
DE69839501D1 (de) 1997-02-27 2008-06-26 Cellomics Inc System für Screening biologischer Zellen
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
US7122304B2 (en) 1997-05-12 2006-10-17 Whatman, Inc. Methods for the storage and synthesis of nucleic acids using a solid support
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
ATE423622T1 (de) 1998-05-01 2009-03-15 Gen Probe Inc Automatisches isolierungs- und amplifizierungsverfahren für eine zielnukleinsäuresequenz
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
WO2000029619A2 (en) * 1998-11-13 2000-05-25 Mosaic Technologies Multielement analytical device for assay of nucleic acid sequences and uses therefore
DE19956820A1 (de) * 1999-11-25 2001-05-31 Roche Diagnostics Gmbh Spezies-spezifischer Nachweis von Nukleinsäuren mittels eines Analyseelementes
AU2073801A (en) 1999-12-09 2001-06-18 Cellomics, Inc. A system for cell-based screening
EP1287114B1 (en) 2000-06-08 2016-08-10 The Regents of The University of California Visual-servoing optical microscopy
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
AU2005241112B2 (en) * 2001-07-13 2009-07-30 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US20110111389A1 (en) * 2001-11-07 2011-05-12 Diagcor Bioscience Incorporation Limited Rapid genotyping analysis for human papillomavirus and the device thereof
US7732138B2 (en) 2001-11-07 2010-06-08 Diagcor Bioscience Incorporation Limited Rapid genotyping analysis and the device thereof
ATE497837T1 (de) 2004-04-09 2011-02-15 Vivebio Llc Vorrichtungen und verfahren für abnahme, lagerung und transport von biologischen proben
EP2322940B1 (en) 2005-03-10 2014-10-29 Gen-Probe Incorporated Systems amd methods to perform assays for detecting or quantifing analytes within samples
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
GB2475630A (en) * 2006-03-11 2011-05-25 Central Science Lab Representing The Sec Dep For Environment Food And Rural Affairs Two-stage detection assay
US7749775B2 (en) * 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
HK1129808A2 (en) * 2007-10-03 2009-12-04 Diagcor Bioscience Inc Ltd Reversed flow through platform for rapid analysis of target analytes with increased sensitivity and specificity and the device thereof
US8250441B2 (en) * 2007-12-11 2012-08-21 Wi-Lan Inc. Outer coding framework for application packet error rate minimization
CN102459626A (zh) * 2009-06-02 2012-05-16 莫诺夸特有限公司 核酸扩增方法
US9592511B2 (en) * 2010-05-19 2017-03-14 Curetis Gmbh Reaction vessel for PCR device and method of performing PCR
EP2752671A3 (en) 2010-07-23 2016-08-24 Beckman Coulter, Inc. System or method of including analytical units
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
EP2484448A1 (en) * 2011-02-03 2012-08-08 Universite De Geneve Non-card format devices for collecting, storing & analysing dried body fluid spots and related methods
WO2012116308A1 (en) 2011-02-24 2012-08-30 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
EP2776844B1 (en) 2011-11-07 2020-09-30 Beckman Coulter, Inc. Specimen container detection
CN104040352B (zh) 2011-11-07 2016-09-07 贝克曼考尔特公司 机械臂
JP2014532881A (ja) 2011-11-07 2014-12-08 ベックマン コールター， インコーポレイテッド 標本輸送システムのための磁気制動
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター， インコーポレイテッド 等分機システムおよびワークフロー
GB201120626D0 (en) * 2011-11-30 2012-01-11 Ge Healthcare Uk Ltd Biological sample storage apparatus and method
US10001497B2 (en) 2013-03-15 2018-06-19 Abbott Laboratories Diagnostic analyzers with pretreatment carousels and related methods
CN109358202B (zh) 2013-03-15 2023-04-07 雅培制药有限公司 具有竖直布置的圆盘传送带的自动化诊断分析仪及相关方法
EP4365601A2 (en) 2013-03-15 2024-05-08 Abbott Laboratories Automated diagnostic analyzers having rear accessible track systems and related methods
US9981264B2 (en) 2014-11-04 2018-05-29 Grace Bio-Labs, Inc. Nitrocellulose extrusion for porous film strips
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652517A (en) * 1984-06-11 1987-03-24 Diagnostic Research Limited Partnership Methods for the in vitro detection and identification of unknown pathogens or genetic entities
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US4837145A (en) * 1986-06-09 1989-06-06 Liotta Lance A Layered immunoassay using antibodies bound to transport particles to determine the presence of an antigen
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
US4956275A (en) * 1987-04-14 1990-09-11 Molecular Devices Corporation Migratory detection immunoassay
US4963658A (en) * 1987-09-04 1990-10-16 Molecular Devices Corporation DNA detection method
US4981786A (en) * 1987-09-04 1991-01-01 Syntex (U.S.A.) Inc. Multiple port assay device
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
WO1989010979A1 (en) * 1988-05-10 1989-11-16 E.I. Du Pont De Nemours And Company Process for rapid nucleic acid detection
IT1227293B (it) * 1988-10-06 1991-04-05 Boehringer Biochemia Srl Dispositivo e metodo per la diagnosi di gravidanza
WO1991006659A1 (en) * 1989-10-24 1991-05-16 Pbs-Orgenics Method and apparatus for the diagnosing of viral and genetic diseases
GB8927503D0 (en) * 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences

Also Published As

Publication number Publication date
DE69216640D1 (de) 1997-02-20
WO1993007292A1 (en) 1993-04-15
ATE147440T1 (de) 1997-01-15
AU2789492A (en) 1993-05-03
DE69216640T2 (de) 1997-06-19
JPH07501933A (ja) 1995-03-02
US5527673A (en) 1996-06-18
EP0612354A1 (en) 1994-08-31
EP0612354B1 (en) 1997-01-08

Similar Documents

Publication Publication Date Title
IL102486A (en) Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe
AU586719B2 (en) Method and apparatus for delivering a predetermined quantity of plasma from a blood sample for analysis purposes
AU626737B2 (en) Method for determining the presence and/or concentration of an analyte in a liquid medium
DK167885A (da) Nitromethylenderivater, mellemprodukter til fremstilling deraf, fremgangsmaade til deres fremstilling samt insecticider
KR970706493A (ko) 분석 검출용 위치 검출 스트립(Position dectable strip for analyte detection)
EP0245512A4 (en) METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF ASPHALES.
JPS52134075A (en) Method and apparatus for testing recess containing culture medium
NO870613D0 (no) Deteksjon av mikroorganismer i en proeve inneholdende nukleinsyre.
ATE76508T1 (de) Vorrichtung zur feststellung von okkultem blut.
DE69609316D1 (de) Verfahren zur markierung von intracytoplasmatischen molekülen
EP0573715A3 (en) Method and device for continuously measuring the concentration of dissolved chemicals.
ATE274237T1 (de) Anlage zur nassbehandlung von substraten
NO164384C (no) Fremgangsmaate og reagenssystem for detektering av en spesiell polynukleotidsekvens i et forsoeksmedium som inneholder enkeltkjedede nukleinsyrer.
FI91451B (fi) Laite koeliuskojen asettamiseksi yksitellen
GB2029025B (en) Method and apparatus for determining the concentration of a carbon source or of an l-amino acid
DE3162539D1 (en) Method and device for detecting glucose concentration
DE3163238D1 (en) Method and device for detecting glucose concentration
DE69515416D1 (de) Verfahren zum Nachweis von Interferonaktivität
EP0283613A3 (en) Dry test strip suitable for oxygen demanding detection system
DE3874605D1 (de) Mikrosonde in integrierter schalttechnik zur feststellung bestimmter gase.
NO174262C (no) Middel for påvisning og bestemmelse av peroksydase-aktivitet
ZA865767B (en) Homogeneous process for the detection and/or determination by luminescence of an analyte in a medium in which it may be present
EP0242029A3 (en) Method and articles employing ion exchange material
DE3669789D1 (de) Vorrichtung zum transport von magnetischem entwickler.
ES2002133A6 (es) Dispositivo para la determinacion de un grupo sanguineo

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired