IL101947A - 3-קרבוקסי-סטרואידים בלתי-רוויים ב 71-מותמרים הכנתם ותכשירי רוקחות המכילים אותם - Google Patents

3-קרבוקסי-סטרואידים בלתי-רוויים ב 71-מותמרים הכנתם ותכשירי רוקחות המכילים אותם

Info

Publication number
IL101947A
IL101947A IL10194792A IL10194792A IL101947A IL 101947 A IL101947 A IL 101947A IL 10194792 A IL10194792 A IL 10194792A IL 10194792 A IL10194792 A IL 10194792A IL 101947 A IL101947 A IL 101947A
Authority
IL
Israel
Prior art keywords
group
compound
formula
carbamoyl
diene
Prior art date
Application number
IL10194792A
Other languages
English (en)
Inventor
Achille Panzeri
Marcella Nesi
Enrico Di Salle
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL101947A publication Critical patent/IL101947A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
  • Details Of Garments (AREA)
  • Ceramic Products (AREA)
  • Medicines Containing Plant Substances (AREA)
IL10194792A 1991-05-24 1992-05-21 3-קרבוקסי-סטרואידים בלתי-רוויים ב 71-מותמרים הכנתם ותכשירי רוקחות המכילים אותם IL101947A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911432A IT1259419B (it) 1991-05-24 1991-05-24 Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi

Publications (1)

Publication Number Publication Date
IL101947A true IL101947A (he) 1996-01-19

Family

ID=11359980

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10194792A IL101947A (he) 1991-05-24 1992-05-21 3-קרבוקסי-סטרואידים בלתי-רוויים ב 71-מותמרים הכנתם ותכשירי רוקחות המכילים אותם

Country Status (26)

Country Link
US (1) US5212166A (he)
EP (2) EP0517047A1 (he)
JP (1) JP3226919B2 (he)
CN (1) CN1035055C (he)
AT (1) ATE155792T1 (he)
AU (1) AU655280B2 (he)
CA (1) CA2087953A1 (he)
CZ (1) CZ281309B6 (he)
DE (1) DE69221074T2 (he)
DK (1) DK0540717T3 (he)
ES (1) ES2106185T3 (he)
FI (1) FI930277A (he)
HU (1) HUT64083A (he)
ID (1) ID954B (he)
IE (1) IE921634A1 (he)
IL (1) IL101947A (he)
IT (1) IT1259419B (he)
MX (1) MX9202438A (he)
MY (1) MY131089A (he)
NO (1) NO930244L (he)
NZ (1) NZ242850A (he)
RU (1) RU2104283C1 (he)
TW (1) TW213467B (he)
WO (1) WO1992020700A1 (he)
YU (1) YU52992A (he)
ZA (1) ZA923758B (he)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022333A1 (en) * 1992-04-30 1993-11-11 Smithkline Beecham Corporation 17α AND 17β-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
DE69431662T2 (de) * 1993-09-03 2003-09-18 Smithkline Beecham Corp Stabilisierte tablettenformulierung
GB9324371D0 (en) * 1993-11-26 1994-01-12 Erba Carlo Spa Side chain fluoro substituted 3-carboxysteroids
US5430157A (en) * 1993-12-13 1995-07-04 Eli Lilly And Company Reduced phenanthrenes
GB9402041D0 (en) * 1994-02-03 1994-03-30 Smithkline Beecham Corp Compounds
US5714480A (en) * 1994-03-31 1998-02-03 Smithkline Beecham Corporation Treating cardiovascular disease with steroidal 5-alpha-reductase inhibitors
WO1995028413A1 (en) * 1994-04-15 1995-10-26 Smithkline Beecham Corporation 17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE
GB9415183D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 3-carboxysteroids with a fluorinated side-chain
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041433A (en) * 1987-04-29 1991-08-20 Smithkline Beecham Corporation 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
DE69311837T2 (de) * 1992-04-20 1998-02-12 Sankyo Co Steroide zur Behandlung von Prostatisch-Hypertrophe, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
IT1259419B (it) 1996-03-18
IE921634A1 (en) 1992-12-02
FI930277A0 (fi) 1993-01-22
TW213467B (he) 1993-09-21
US5212166A (en) 1993-05-18
RU2104283C1 (ru) 1998-02-10
ID954B (id) 1996-09-25
EP0540717A1 (en) 1993-05-12
ES2106185T3 (es) 1997-11-01
JP3226919B2 (ja) 2001-11-12
ZA923758B (en) 1993-01-27
MX9202438A (es) 1992-11-01
ATE155792T1 (de) 1997-08-15
ITMI911432A1 (it) 1992-11-24
CZ281309B6 (cs) 1996-08-14
CA2087953A1 (en) 1992-11-25
NO930244D0 (no) 1993-01-25
YU52992A (sh) 1995-03-27
ITMI911432A0 (it) 1991-05-24
HUT64083A (en) 1993-11-29
DE69221074T2 (de) 1997-11-13
JPH06500342A (ja) 1994-01-13
AU655280B2 (en) 1994-12-15
DK0540717T3 (da) 1997-08-18
FI930277A (fi) 1993-01-22
NZ242850A (en) 1994-01-26
EP0517047A1 (en) 1992-12-09
CN1067057A (zh) 1992-12-16
EP0540717B1 (en) 1997-07-23
NO930244L (no) 1993-01-27
DE69221074D1 (de) 1997-09-04
CZ26593A3 (en) 1993-11-17
MY131089A (en) 2007-07-31
AU1778192A (en) 1992-12-30
WO1992020700A1 (en) 1992-11-26
HU9300176D0 (en) 1993-04-28
CN1035055C (zh) 1997-06-04

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Legal Events

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FF Patent granted