IL101600A - Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them - Google Patents

Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them

Info

Publication number
IL101600A
IL101600A IL10160092A IL10160092A IL101600A IL 101600 A IL101600 A IL 101600A IL 10160092 A IL10160092 A IL 10160092A IL 10160092 A IL10160092 A IL 10160092A IL 101600 A IL101600 A IL 101600A
Authority
IL
Israel
Prior art keywords
synthetic
antisense oligodeoxynucleotides
pct
gene
pharmaceutical compositions
Prior art date
Application number
IL10160092A
Other languages
English (en)
Other versions
IL101600A0 (en
Inventor
Hermona Soreq
Haim Zakut
Fritz Eckstein
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL10160092A priority Critical patent/IL101600A/xx
Publication of IL101600A0 publication Critical patent/IL101600A0/xx
Priority to AU40399/93A priority patent/AU665087B2/en
Priority to JP5517984A priority patent/JPH08504083A/ja
Priority to US08/318,826 priority patent/US5891725A/en
Priority to DE69308833T priority patent/DE69308833T2/de
Priority to AT93911467T priority patent/ATE150029T1/de
Priority to PCT/EP1993/000911 priority patent/WO1993021202A1/en
Priority to EP93911467A priority patent/EP0636137B1/en
Priority to CA002118235A priority patent/CA2118235C/en
Priority to US08/850,347 priority patent/US6110742A/en
Publication of IL101600A publication Critical patent/IL101600A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01007—Acetylcholinesterase (3.1.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01008—Cholinesterase (3.1.1.8), i.e. butyrylcholine-esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
IL10160092A 1992-04-15 1992-04-15 Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them IL101600A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL10160092A IL101600A (en) 1992-04-15 1992-04-15 Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them
CA002118235A CA2118235C (en) 1992-04-15 1993-04-15 Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
DE69308833T DE69308833T2 (de) 1992-04-15 1993-04-15 Synthetische "antisense" oligonucleoside und diese enthaltende arzneimittel
JP5517984A JPH08504083A (ja) 1992-04-15 1993-04-15 合成アンチセンスオリゴデオキシヌクレオチドとそれらを含む医薬組成物
US08/318,826 US5891725A (en) 1992-04-15 1993-04-15 Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
AU40399/93A AU665087B2 (en) 1992-04-15 1993-04-15 Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
AT93911467T ATE150029T1 (de) 1992-04-15 1993-04-15 Synthetische ''antisense'' oligonucleoside und diese enthaltende arzneimittel
PCT/EP1993/000911 WO1993021202A1 (en) 1992-04-15 1993-04-15 Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
EP93911467A EP0636137B1 (en) 1992-04-15 1993-04-15 Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
US08/850,347 US6110742A (en) 1992-04-15 1997-05-02 Synthetic antisense oligodeoxynucleotides targeted to AChE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10160092A IL101600A (en) 1992-04-15 1992-04-15 Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL101600A0 IL101600A0 (en) 1992-12-30
IL101600A true IL101600A (en) 2000-02-29

Family

ID=11063549

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10160092A IL101600A (en) 1992-04-15 1992-04-15 Synthetic partially phosphorothioated antisense oligodeoxynucleotides and pharmaceutical compositions containing them

Country Status (9)

Country Link
US (1) US5891725A (xx)
EP (1) EP0636137B1 (xx)
JP (1) JPH08504083A (xx)
AT (1) ATE150029T1 (xx)
AU (1) AU665087B2 (xx)
CA (1) CA2118235C (xx)
DE (1) DE69308833T2 (xx)
IL (1) IL101600A (xx)
WO (1) WO1993021202A1 (xx)

Families Citing this family (72)

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CA2110946A1 (en) 1992-12-09 1994-06-10 Elazar Rabbani Induction of immunocompatibility by nucleic acid
GB9519299D0 (en) 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
US8551970B2 (en) 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
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US6475998B1 (en) * 1997-03-06 2002-11-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for the treatment of injury to the central nervous system
US6869795B1 (en) 1999-10-07 2005-03-22 Avi Biopharma, Inc. Antisense compositions and cancer-treatment methods
JP2003511393A (ja) * 1999-10-07 2003-03-25 エイブイアイ バイオファーマ， インコーポレイテッド アンチセンス組成物および癌処置法
IL132972A0 (en) * 1999-11-16 2001-03-19 Yissum Res Dev Co Pharmaceutical compositions comprising acetylcholinesterase antisense deoxynucleotides for the treatment of muscular and neuromuscular disorders
US6770799B2 (en) * 2000-03-17 2004-08-03 Thompson Boyce Plant Res Expression of recombinant human acetylcholinesterase in transgenic plants
IL143379A (en) * 2001-05-24 2013-11-28 Yissum Res Dev Co Oligonucleotide against human ache isoform r and its uses
US6989261B2 (en) * 2001-12-20 2006-01-24 Eli Lilly And Company Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US7049121B2 (en) * 2001-12-20 2006-05-23 Applied Molecular Evolution Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
WO2003054182A2 (en) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production of butyrylcholinesterases in transgenic mammals
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
US7480382B2 (en) * 2003-09-30 2009-01-20 Microsoft Corporation Image file container
IL158600A (en) * 2003-10-26 2015-07-30 Hermona Soreq Dioxysoligonucleotide Antisense Against Acetylcholinesterase as an Anti-Inflammatory Agent
US7968762B2 (en) * 2004-07-13 2011-06-28 Van Andel Research Institute Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
CN101437933B (zh) * 2005-12-28 2013-11-06 斯克里普斯研究所 作为药物靶标的天然反义和非编码的rna转录物
WO2008019036A2 (en) * 2006-08-04 2008-02-14 Pharmathene Inc. Long half-life recombinant butyrylcholinesterase
RU2604489C2 (ru) * 2008-10-03 2016-12-10 КьюРНА,Инк.,US Лечение заболеваний, связанных с аполипопротеином-а1, путем ингибирования природного антисмыслового транскрипта аполипопротеина-а1
EP2727996A1 (en) 2008-11-06 2014-05-07 The Johns-Hopkins University Treatment of chronic inflammatory respiratory disorders with NP1 inhibitors
EP2373338B1 (en) 2008-12-03 2017-02-15 The Johns Hopkins University Annexina2 as immunological target
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CA2755404C (en) 2009-03-17 2020-03-24 Joseph Collard Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
CA2761142C (en) 2009-05-06 2021-06-08 Opko Curna, Llc Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
CN103223177B (zh) 2009-05-06 2016-08-10 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
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CN102575251B (zh) 2009-05-18 2018-12-04 库尔纳公司 通过抑制针对重编程因子的天然反义转录物来治疗重编程因子相关的疾病
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JP6128846B2 (ja) 2009-06-16 2017-05-17 クルナ・インコーポレーテッド パラオキソナーゼ（ｐｏｎ１）に対する天然アンチセンス転写物の抑制によるｐｏｎ１遺伝子関連疾患の治療
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Also Published As

Publication number Publication date
ATE150029T1 (de) 1997-03-15
EP0636137A1 (en) 1995-02-01
AU665087B2 (en) 1995-12-14
AU4039993A (en) 1993-11-18
US5891725A (en) 1999-04-06
DE69308833D1 (de) 1997-04-17
CA2118235A1 (en) 1993-10-28
JPH08504083A (ja) 1996-05-07
DE69308833T2 (de) 1997-06-19
CA2118235C (en) 2008-07-15
WO1993021202A1 (en) 1993-10-28
IL101600A0 (en) 1992-12-30
EP0636137B1 (en) 1997-03-12

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