IES20180261A2 - Drug intermediates 3,4,5-trimethoxybenzaldehyde synthesis method - Google Patents
Drug intermediates 3,4,5-trimethoxybenzaldehyde synthesis methodInfo
- Publication number
- IES20180261A2 IES20180261A2 IES20180261A IES20180261A2 IE S20180261 A2 IES20180261 A2 IE S20180261A2 IE S20180261 A IES20180261 A IE S20180261A IE S20180261 A2 IES20180261 A2 IE S20180261A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- trimethoxybenzaldehyde
- added
- temperature
- synthesis method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses drug intermediates 3,4,5-trimethoxybenzaldehyde synthesis method, comprises the following steps: the reaction vessel is charged with 2,6-dibromo-3,4,5-trimethoxy-benzyl alcohol and hexane, controls the temperature of the solution, the aqueous solution, potassium peroxodisulfate are added, continues to react; then sodium nitrate solution and chlorine iridium acid powder are added, raises the temperature, continues to react, sodium chloride solution is added, reduces the temperature, standing, after the solution layers, washed with biphenyl solution, recrystallized in the o-dinitrobenzene solution, dehydrated with dehydration, gets the finished product 3,4,5-trimethoxybenzaldehyde. <Figure 1>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710797628.2A CN108238882A (en) | 2017-09-07 | 2017-09-07 | The synthetic method of pharmaceutical intermediate 3,4,5-Trimethoxybenzaldehyde |
Publications (1)
Publication Number | Publication Date |
---|---|
IES20180261A2 true IES20180261A2 (en) | 2019-11-13 |
Family
ID=60117386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IES20180261 IES20180261A2 (en) | 2017-09-07 | 2018-08-23 | Drug intermediates 3,4,5-trimethoxybenzaldehyde synthesis method |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN108238882A (en) |
AU (1) | AU2018101124A4 (en) |
GB (1) | GB201714446D0 (en) |
IE (1) | IES20180261A2 (en) |
-
2017
- 2017-09-07 CN CN201710797628.2A patent/CN108238882A/en active Pending
- 2017-09-08 GB GBGB1714446.0A patent/GB201714446D0/en not_active Ceased
-
2018
- 2018-08-11 AU AU2018101124A patent/AU2018101124A4/en not_active Ceased
- 2018-08-23 IE IES20180261 patent/IES20180261A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB201714446D0 (en) | 2017-10-25 |
CN108238882A (en) | 2018-07-03 |
AU2018101124A4 (en) | 2018-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FJ9A | Application deemed to be withdrawn section 31(3) |