IE20180284U1 - 2,3-dihydroxy-succinic acid drug intermediates synthesis method - Google Patents

2,3-dihydroxy-succinic acid drug intermediates synthesis method

Info

Publication number
IE20180284U1
IE20180284U1 IE20180284U IE20180284U IE20180284U1 IE 20180284 U1 IE20180284 U1 IE 20180284U1 IE 20180284 U IE20180284 U IE 20180284U IE 20180284 U IE20180284 U IE 20180284U IE 20180284 U1 IE20180284 U1 IE 20180284U1
Authority
IE
Ireland
Prior art keywords
solution
added
dihydroxy
succinic acid
temperature
Prior art date
Application number
IE20180284U
Inventor
Yan Yida
Original Assignee
Chengdu Ao Ka Te Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Ao Ka Te Tech Co Ltd filed Critical Chengdu Ao Ka Te Tech Co Ltd
Publication of IE20180284U1 publication Critical patent/IE20180284U1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/04—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses drug intermediates 2,3-dihydroxy-succinic acid drug intermediates synthesis method, comprises the following steps: 1,4-dibromo-2,3-dimethoxy-butyl dialdehyde, heptane solution was added to the reaction vessel, controlled the stirring speed, raised the temperature of the solution, added the aqueous solution, added dimethyl sulfoxide, added sebacic acid dioctyl ester solution in batches, continued to react; raised the temperature of the solution, added potassium bromide solution, added zinc acetate powder, continued to react, reduced the temperature, standed, added sodium nitrate solution, the solution is layered, the oil layer was separated, washed with 3-hexanol solution, recrystallized in cyclic valerate solution, dehydrated with dehydration, got the finished product 2,3-dihydroxy-succinic acid. <Figure 1>
IE20180284U 2017-09-17 2018-08-23 2,3-dihydroxy-succinic acid drug intermediates synthesis method IE20180284U1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710835773.5A CN108285413A (en) 2017-09-17 2017-09-17 2,3 dihydroxybutanedioic acid pharmaceutical intermediate synthetic method

Publications (1)

Publication Number Publication Date
IE20180284U1 true IE20180284U1 (en) 2020-10-14

Family

ID=60805738

Family Applications (1)

Application Number Title Priority Date Filing Date
IE20180284U IE20180284U1 (en) 2017-09-17 2018-08-23 2,3-dihydroxy-succinic acid drug intermediates synthesis method

Country Status (4)

Country Link
CN (1) CN108285413A (en)
AU (1) AU2018101143A4 (en)
GB (1) GB201719123D0 (en)
IE (1) IE20180284U1 (en)

Also Published As

Publication number Publication date
GB201719123D0 (en) 2018-01-03
CN108285413A (en) 2018-07-17
AU2018101143A4 (en) 2018-09-13

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