IE821314L - Preparing 2-(2-thienyl) and 2-(3-thienyl)-ethylamines - Google Patents

Preparing 2-(2-thienyl) and 2-(3-thienyl)-ethylamines

Info

Publication number
IE821314L
IE821314L IE821314A IE131482A IE821314L IE 821314 L IE821314 L IE 821314L IE 821314 A IE821314 A IE 821314A IE 131482 A IE131482 A IE 131482A IE 821314 L IE821314 L IE 821314L
Authority
IE
Ireland
Prior art keywords
thienyl
formula
compound
see diagramm
ethylamines
Prior art date
Application number
IE821314A
Other versions
IE53278B1 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IE821314L publication Critical patent/IE821314L/en
Publication of IE53278B1 publication Critical patent/IE53278B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

1. Process for the preparation of 2-(2-thienyl)- and -(3-thienyl-ethylamines of the formula I : see diagramm : EP0069002,P5,F2 in which R1 and R2 , which may be the same or different, represent each a hydrogen atom, a straight- or branched-chain alkyl radical, a heterocyclic or non-heterocyclic aromatic radical, optionally mono- or poly-substituted, comprising catalytically hydrogenating in non alcaline medium in an alcohol or an organic acid or their mixture under a hydrogen pressure of 1 to 100 atmospheres at a temperature of 20 to 100 degrees C, and in the presence of a metal catalyst associated with an inert carrier, a compound of the formula IV : see diagramm : EP0069002,P5,F3 in which R1 and R2 are as defined above, to give a compound of the formula V : see diagramm : EP0069002,P5,F4 in which R1 and R2 are as defined above, isolating compound (V) and then catalytically hydrogenating same in alcaline medium under a hydrogen pressure of 1 to 100 atmospheres, at a temperature of 20 to 100 degrees C, and in the presence of a metal catalyst on a carrier to give a compound of the formula (I). [EP0069002A1]
IE1314/82A 1981-06-30 1982-06-01 Process for preparing 2-(2-thienyl)-ethylamines and 2-(3-thienyl)-ethylamines IE53278B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8113066A FR2508456A1 (en) 1981-06-30 1981-06-30 PROCESS FOR THE PREPARATION OF (THIENYL-2) -2 ETHYLAMINES AND (THIENYL-3) -2 ETHYLAMINES

Publications (2)

Publication Number Publication Date
IE821314L true IE821314L (en) 1982-12-30
IE53278B1 IE53278B1 (en) 1988-09-28

Family

ID=9260133

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1314/82A IE53278B1 (en) 1981-06-30 1982-06-01 Process for preparing 2-(2-thienyl)-ethylamines and 2-(3-thienyl)-ethylamines

Country Status (24)

Country Link
EP (1) EP0069002B1 (en)
JP (1) JPS5810575A (en)
KR (1) KR840000539A (en)
AR (1) AR231444A1 (en)
AT (1) ATE15369T1 (en)
AU (1) AU556916B2 (en)
CA (1) CA1205811A (en)
CS (1) CS236482B2 (en)
DD (1) DD202711A5 (en)
DE (1) DE3266028D1 (en)
DK (1) DK153793C (en)
ES (1) ES8305348A1 (en)
FI (1) FI822318L (en)
FR (1) FR2508456A1 (en)
GR (1) GR77203B (en)
HU (1) HU186867B (en)
IE (1) IE53278B1 (en)
IL (1) IL65984A (en)
NO (1) NO155345C (en)
NZ (1) NZ200856A (en)
PT (1) PT75156B (en)
SU (1) SU1148562A3 (en)
YU (1) YU142982A (en)
ZA (1) ZA824618B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
FR2608607B1 (en) * 1986-12-23 1989-04-28 Sanofi Sa PROCESS FOR THE PREPARATION OF THIENYLETHYLAMINES AND DITHIENYLETHYLAMINES THUS OBTAINED
CA1309719C (en) * 1987-02-26 1992-11-03 Thomas M. Bargar Heterocycly1-2-propyn-1-amines
FR2622191B1 (en) * 1987-10-22 1991-06-21 Sanofi Sa PROCESS FOR THE PREPARATION OF N- (2-CHLORO-BENZYL) -2 ETHYLAMINE AND INTERMEDIATE PRODUCTS IN THIS PREPARATION
US4906756A (en) * 1988-05-10 1990-03-06 Syntex (U.S.A.) Inc. 2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
US5191090A (en) * 1990-01-25 1993-03-02 Syntex (U.S.A.) Inc. Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
FR2664276B1 (en) * 1990-07-04 1992-10-23 Sanofi Sa GLYCIDIC THIENYL-2 DERIVATIVE, ITS PREPARATION METHOD AND ITS USE AS A SYNTHESIS INTERMEDIATE.
US5208252A (en) * 1992-07-24 1993-05-04 Ortho Pharmaceutical Corporation Aminoethylthiophene derivatives
GB201818117D0 (en) * 2018-11-06 2018-12-19 Syngenta Participations Ag Enantioselective process

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2623174A1 (en) * 1976-05-22 1977-12-01 Basf Ag Primary amine prepn. from oximes - by hydrogenation in presence of ammonia with catalysts contg. aluminium and nickel and/or cobalt

Also Published As

Publication number Publication date
PT75156A (en) 1982-07-01
EP0069002A1 (en) 1983-01-05
ES514220A0 (en) 1983-04-01
DE3266028D1 (en) 1985-10-10
FR2508456B1 (en) 1983-09-09
JPH039914B2 (en) 1991-02-12
SU1148562A3 (en) 1985-03-30
KR840000539A (en) 1984-02-25
JPS5810575A (en) 1983-01-21
EP0069002B1 (en) 1985-09-04
AR231444A1 (en) 1984-11-30
NO155345C (en) 1987-03-18
DK153793C (en) 1989-01-23
YU142982A (en) 1984-12-31
FR2508456A1 (en) 1982-12-31
AU556916B2 (en) 1986-11-27
PT75156B (en) 1984-02-21
DD202711A5 (en) 1983-09-28
GR77203B (en) 1984-09-11
CS236482B2 (en) 1985-05-15
FI822318A0 (en) 1982-06-29
ES8305348A1 (en) 1983-04-01
DK291782A (en) 1982-12-31
NO822228L (en) 1983-01-03
IL65984A (en) 1985-09-29
DK153793B (en) 1988-09-05
FI822318L (en) 1982-12-31
ZA824618B (en) 1983-04-27
IE53278B1 (en) 1988-09-28
NZ200856A (en) 1985-11-08
CA1205811A (en) 1986-06-10
ATE15369T1 (en) 1985-09-15
NO155345B (en) 1986-12-08
AU8475282A (en) 1983-01-06
IL65984A0 (en) 1982-09-30
HU186867B (en) 1985-10-28

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Legal Events

Date Code Title Description
MK9A Patent expired