GB935406A - Novel piperazine derivatives and a process for the manufacture thereof - Google Patents
Novel piperazine derivatives and a process for the manufacture thereofInfo
- Publication number
- GB935406A GB935406A GB1527/62A GB152762A GB935406A GB 935406 A GB935406 A GB 935406A GB 1527/62 A GB1527/62 A GB 1527/62A GB 152762 A GB152762 A GB 152762A GB 935406 A GB935406 A GB 935406A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- group
- alkoxy
- amino
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises: compounds of the general formula <FORM:0935406/IV(a)/1> (wherein R represents a phenyl radical optionally substituted by a halogen atom or an alkyl, alkoxy, hydroxy, nitro, amino, alkylamino or dialkylamino group, and R1 represents a pyridyl radical) and their acid addition salts; the preparation thereof by reacting a 1-phenylpiperazine, in which the phenyl radical may be substituted by a halogen atom or an alkyl, alkoxy, hydroxy or nitro group, with a vinylpyridine, and, if desired, hydrolysing any alkoxy group in the product to hydroxy, or reducing any nitro group to amino and further, if desired, mono-or di-alkylating the latter, and/or, if desired, converting the product into an acid addition salt; and pharmaceutical compositions containing the products in association with a compatible pharmaceutical carrier. One method of monoalkylating an amino compound consists in acylation followed by reduction of the acyl group. The pharmaceutical compositions, which have tranquillizing, anorexic and hypotensive activity, may be in the form of tablets, drag<\>ees, suppositories, lozenges, suspensions, emulsions or injection solutions.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH71361 | 1961-01-20 | ||
CH419461 | 1961-04-10 | ||
CH1175461 | 1961-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB935406A true GB935406A (en) | 1963-08-28 |
Family
ID=27172340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1527/62A Expired GB935406A (en) | 1961-01-20 | 1962-01-16 | Novel piperazine derivatives and a process for the manufacture thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE612485A (en) |
ES (1) | ES273864A1 (en) |
FR (2) | FR1725M (en) |
GB (1) | GB935406A (en) |
NL (1) | NL273281A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2070687A1 (en) * | 1969-09-12 | 1971-09-17 | Hoechst Ag |
-
0
- FR FR1310270D patent/FR1310270A/fr not_active Expired
- NL NL273281D patent/NL273281A/xx unknown
- BE BE612485D patent/BE612485A/xx unknown
-
1962
- 1962-01-12 FR FR884616A patent/FR1725M/en active Active
- 1962-01-16 GB GB1527/62A patent/GB935406A/en not_active Expired
- 1962-01-19 ES ES0273864A patent/ES273864A1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2070687A1 (en) * | 1969-09-12 | 1971-09-17 | Hoechst Ag |
Also Published As
Publication number | Publication date |
---|---|
BE612485A (en) | |
ES273864A1 (en) | 1962-07-16 |
FR1310270A (en) | 1963-03-06 |
FR1725M (en) | 1963-03-11 |
NL273281A (en) |
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