IE69668B1 - Preparation of Microbubble Echocontrast Agents - Google Patents

Preparation of Microbubble Echocontrast Agents

Info

Publication number
IE69668B1
IE69668B1 IE456391A IE456391A IE69668B1 IE 69668 B1 IE69668 B1 IE 69668B1 IE 456391 A IE456391 A IE 456391A IE 456391 A IE456391 A IE 456391A IE 69668 B1 IE69668 B1 IE 69668B1
Authority
IE
Ireland
Prior art keywords
syringe
mixing chamber
dosage form
contrast medium
gas
Prior art date
Application number
IE456391A
Other versions
IE914563A1 (en
Inventor
Klaus-Dieter Dr Beller
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of IE914563A1 publication Critical patent/IE914563A1/en
Publication of IE69668B1 publication Critical patent/IE69668B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/311—Injector mixers in conduits or tubes through which the main component flows for mixing more than two components; Devices specially adapted for generating foam
    • B01F25/3111—Devices specially adapted for generating foam, e.g. air foam
    • B01F25/31112—Devices specially adapted for generating foam, e.g. air foam with additional mixing means other than injector mixers, e.g. screen or baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • B01F25/43172—Profiles, pillars, chevrons, i.e. long elements having a polygonal cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F25/431971—Mounted on the wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4521—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/714—Feed mechanisms for feeding predetermined amounts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/894—Measuring receptacles therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • B01F35/3202—Hand driven

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Described is a dosage form for micro-bubble echo contrast agents, the unit comprising a syringe (6) and, joined to the syringe, a mixing chamber (1) containing a pre-determined quantity of gas, and a second syringe. The new injection unit enables echo contrast agents to be prepared simply under standardized conditions, and gives a high level of contrast.

Description

Prior Act Numerous preparations which are suitable as echo contrast media and contain surface-active substances which assist with the formation of micro bubbles and stabilise them have been disclosed (for example EP-A-0 077 752). The ultrasound reflected by the micro bubbles is used to improve the ultrasonic images of cavities or vessels filled with fluid in the human and animal body. The micro bubbles are produced only just before administration of the contrast medium.
EP-A-0 077 752 indicates various methods for generating micro bubbles in mixtures containing surfactants and viscosityincreasing substances. It is proposed that these mixtures be drawn up together with a gas several times into a syringe and expelled again. It is alternatively proposed to inject a portion of a mixture into the remaining portion of the mixture which is present together with the gas in a vessel. When carbon dioxide is used as gas it is possible for one portion of the mixture to contain a salt of carbonic acid and the other portion of the mixture an equivalent amount of an acid. It is further proposed to store the mixture together with the gas under elevated pressure in a closed vessel from which the elevated pressure is let off shortly before use, if necessary after shaking.
It is self-evident that it is not possible in this way to prepare contrast media which can be administered in a reproducible manner and which contain a defined amount of gas in micro bubbles of maximally uniform size. Attempts have therefore been made to provide the contrast medium in a - 3 syringe. Before use, the required amount of air is drawn up. Then the syringe is connected by a connector to a second, empty syringe. Vigorous pumping of the contrast medium backwards and forwards between the two syringes produces micro bubbles. However, it has emerged that the care required to obtain reasonably utilisable suspensions of micro bubbles is unacceptable in practice. In addition, a very great amount of force needs to be expended. Standardisation can scarcely be achieved in practice.
EP-A-0 148 116 discloses an apparatus for homogenising microcapsule suspensions which comprises a connector with two female connecting pieces for two syringes to be inserted. The channel through the connector has a constriction which is intended to assist turbulent flow of the fluid which is pumped backwards and forwards between the two syringes.
DE-A-3 838 530 describes a package for a two-component composition, which consists of two flexible containers for the two components. Before use, the two containers are connected together by a tubular adaptor which is provided in its interior with deflectors in a mutually offset arrangement. To mix the components, the contents of the containers are forced backwards and forwards through the adaptor several times.
US-A-4 049 241 discloses a mixing chamber for fluid materials, in which a plurality of rod-like mixing elements are provided in a tubular housing and are inclined with respect to the axis of the tube.
Description of the Invention The invention has the object of providing a dosage form for micro bubble echo contrast media which permits the user to administer the micro bubble echo contrast media In a standardised and optimised manner without unacceptable effort.
Another aim of the invention is to improve the quality of the images of body structures obtainable with a micro bubble echo contrast medium and to improve the reproducibility of the images.
Another aim of the invention is to increase the safety of use by avoiding the production of gas bubbles which, because their diameter is too large, expose the patient to the risk of embolism.
Another aim of the invention is to avoid a risk of infection.
These objects are achieved according to the invention by the subject-matter of Claim 1.
The invention therefore relates to a dosage form for micro bubble echo contrast media comprising a first syringe which is unreleasably connected to a mixing chamber which is provided in its interior with mixing elements which, on operation of the syringe, bring about turbulence of the gaseous and liquid components of the contrast medium, the mixing chamber containing the predetermined amount, which is needed to produce the micro bubbles, of a suitable sterile gas and being closed by a stopper or cap.
Preferred embodiments of the invention are evident from Patent Claims 2-5.
The mixing chamber is preferably tubular and has mixing elements in its inner lumen. Λ In a preferred embodiment, the mixing elements are designed in * the form of spikes, that is to say the mixing elements preferably stand at right angles to the inner wall of the mixing chamber and thus point in the direction of the long axis of the mixing chamber tube. It is expedient to design the mixing elements with sharp edges, that is to say to produce separation edges. There is preferably a mutually offset helical arrangement of the mixing elements. Additional separation edges can be achieved by one or more perforated diaphragms.
Echo contrast media which are in the form of a homogeneous solution can be provided in a syringe or drawn up air-free into a syringe from a storage container such as, for example, an ampoule before use. The syringe is then connected to the free end of the mixing chamber which is firmly connected to a syringe and whose interior volume contains the predetermined amount of gas. The echo contrast medium is pumped through the mixing chamber into the second, empty syringe and subsequently back again into the first syringe. A relatively stable micro bubble suspension has been formed after only a few repetitions of the pumping process. The echo contrast medium is now ready for administration. The user now replaces the empty syringe by an injection needle and injects the contrast medium. It is expedient to inject from the syringe with mixing chamber because in this case injection directly entails passage through the mixing chamber once more.
The syringe with mixing chamber is produced by processes known to the person skilled in the art out of materials customary for such medical articles. For example, the mixing chamber is produced by the injection moulding process and connected unreleasably to the connecting piece of a conventional syringe, for example by adhesive or ultrasonic welding or is produced from the outset in one piece together with the syringe barrel. The free end of the mixing chamber can have the form of a male or female connecting piece. In the case where the free end is designed as male connecting piece, the second syringe has a female connecting piece, or an adaptor with two female connectors is fitted on the male connecting piece of the second syringe. In the case where the free end is designed as female connecting piece, the injection needle is fitted via an adaptor with two male connecting pieces.
It has emerged that the second syringe can be dispensed with when the formation of stable micro bubbles of suitable size is possible with relatively low energy expenditure with the echo contrast medium formulations used. In favourable cases, even the single passage through the mixing chamber on injection suffices to form micro bubbles whose quality and amount are adequate. This procedure is expedient, for example, in investigations of the right ventricle.
The dosage form according to the invention for micro bubble echo contrast media is preferably provided in a set ready for use. If the echo contrast medium consists of a single liquid component, the latter can be, for example, contained in a normal syringe or present in a vial from which it is drawn up air-free into the syringe. The preset amount of gas to be dispersed is located in the mixing chamber. It has proved to be expedient to choose the free interior volume of the mixing chamber such that it corresponds to the volume of the predetermined amount of gas which yields an optimal micro bubble echo contrast medium with the contrast medium components. The connecting pieces of the two syringes are closed with appropriate caps or stoppers. It is expedient to provide the said parts together with an injection needle and, if required, with further aids customary for i.v. use, such as alcohol swab and plaster dressing, sterile in a pack, for example a conventional blister pack.
Suitable contrast medium components are those compositions which yield sufficiently stable micro bubbles on foaming with gases for ultrasonic investigations. The components contain surface-active substances and, if required, further substances promoting the stabilisation of micro bubbles, such as, for example, substances which increase the viscosity. Suitable components are described, for example in EP-A-0 077 752 and EP-A-0 212 568.
According to a particular embodiment of the invention, the dosage form for micro bubble echo contrast media contains 1 to ml, preferably 2 to 8 ml, and particularly preferably 5 ml, of liquid contrast medium component. 0.01 to 0.1, preferably 0.04 to 0.06 ml of gas is then contained per 1 ml of liquid contrast medium component.
A preferred embodiment of the dosage form according to the 10 invention comprises two syringes with an inner volume of 5 ml, of which one is unreleasably connected to a mixing chamber which has an inner volume of 0.18 ml. The syringe which is unreleasably connected to the mixing chamber is empty. The mixing chamber contains 0.18 ml of gas, preferably sterile air, and is closed by either a stopper or a cap. The second syringe contains 3 ml of a liquid contrast medium component. This syringe is also closed by a stopper or cap.
The invention is to be explained in more detail hereinafter by means of Figures 1 to 4.
Fig. 1 shows a longitudinal section through a mixing chamber.
Fig. 2 shows a cross-section through a mixing chamber along the line II in Fig. 1.
Fig. 3 shows a side view of a syringe with mixing chamber.
Fig. 4 shows a side view of a syringe with mixing chamber with second syringe attached.
Fig. 1 depicts an embodiment of the mixing chamber 1 in longitudinal section. The cylindrical tubular sleeve 2 has mixing elements 3 which stand at right angles to its interior wall and have a mutually offset helical or spiral arrangement. A connecting piece 4 is shaped at the left-hand end and is designed as male Luer connection. A connecting piece 5 is shaped on the right-hand end and is designed as female Luer connection. It appears expedient, for reasons of production technique, to fabricate the mixing chamber from three parts, that is to say from the tubular sleeve 2 with the mixing elements 3 and the two connecting pieces 4, 5 and to connect in a suitable manner. The connection lines are designated 8 and 9 in Fig. 1. The connecting piece 5 can be directly replaced by a corresponding connecting part of a piston syringe. As mentioned hereinbefore, the connecting piece 4 can also be in the form of a female Luer connection. If required, a perforated diaphragm 12 is provided in the connecting piece 4. An intensification of the dispersion can be achieved by this optional perforated diaphragm 12.
Fig. 2 shows a cross-section through a mixing chamber along the line II in Fig. 1. The mixing elements 3 in the form of spikes standing at right angles on the inner wall of the tubular sleeve 2 are seen.
Fig. 3 depicts a syringe 6 with mixing chamber 1 with male connecting piece, where the mixing chamber 1 is directly shaped on the base of the syringe barrel.
Fig. 4 shows the syringe 6 with mixing chamber 1 which is shaped on and onto whose male connecting pieces is fitted a second syringe 10 which contains the echo contrast medium 11. The amount of gas required for the micro bubbles is contained in mixing chamber 1. The micro bubble suspension ready for administration is prepared by pumping the echo contrast medium 11 backwards and forwards between syringe 10 and syringe 6 through mixing chamber 1.
The dosage form according to the invention achieves increased safety of use. It should be particularly emphasised in this connection that, owing to the predetermined amount of gas, exactly the amount of gas which is optimally suited to the composition and amount of the liquid component is used, and thus leads to a maximum information content of the obtainable images. Errors which may arise through conventional drawing up of too much or too little gas are reliably avoided thereby.
In particular, the drawing up of too much gas might result in a risk of embolism for the patient. However, even the drawing up of too little gas in the conventional method may make repetition of the investigation necessary because of deficient imaging. In addition, the risk of infection for the patient is considerably reduced by the dosage form according to the invention because, in contrast to the drawing up of ambient air which has been hitherto customary, sterile gas is used and no ambient air which may be contaminated with resistant hospital organisms enters the blood circulation of the patient via the micro bubbles. An additional factor is that connection procedures are avoided, owing to the unreleasable connection between mixing chamber and syringe, with regard to possible intrusion of organisms.
The safety of use is also greatly improved by the possibility now of considerably reducing the number of backward and forward pumping procedures, while there is a simultaneous increase in the quality of the micro bubble suspension. Since, in addition, the force expenditure necessary for the pumping backwards and forwards is considerably reduced, there is an increased readiness of the user to carry out,the foaming procedure in accordance with the instructions until the state ς of the micro bubble echo contrast medium is optimal for the intended purpose. e The dosage form according to the invention results in micro bubble suspensions which are distinguished by a surprising improved quality of contrast.
In addition, it has been observed that, after disappearance of the contrast from the lumen of the body cavities investigated, the inner surfaces of the body cavities surprisingly remain readily visible for a substantial period. For example, this marking of surfaces, which has to date been observed only with dosage forms according to the invention, is outstandingly suitable for diagnosis of the heart. It appears that the dosage forms according to the invention favours the formation of micro bubbles adhering to interior body surfaces.
In a comparative test, 3 ml samples of an infusion solution containing crosslinked polypeptides (Haemaccel* supplied by Behringwerke), which is suitable for the preparation of micro bubble contrast media, were pumped backwards and forwards together with 0.18 ml of air, on the one hand five times between two syringes connected by a three way tap (test A), and on the other hand five times in a dosage form according to the invention between the syringe connected to a mixing chamber and a syringe attached to the mixing chamber (test B). Subsequently dosage forms A and B were administered i.v. to conscious dogs. Echocardiography of the right ventricle was carried out with a Sonoscope 4 at 3.5 MHz. The resulting video printouts were evaluated by densitometry. The densitometer (Gretag D182) measures changes in the brightness in the range from 0.00 to 2.50 DU (density units) in 100 steps. The calibration is based On the calibration card which is provided by the manufacturer and complies with DIN 16536 (calibration reference), where the brightest white is assigned the value 1.64 and the darkest black is assigned the value 0.00. The value for each animal is determined from the mean of four individual measurements within a square centimetre.
The following results were obtained : Contrast maximum 10 sec 20 sec quality intensity after after adminis- adminis 5 tration tration Test A poor 1.06 0.39 0.19 Test B good 1.56 1.09 0.58 It is evident, that in addition to the easier and safer use, the dosage form according to the invention results not only in a considerably improved contrast quality but also in a surprising increase in intensity and the qualitatively and quantitatively superior contrast is in fact observable for very much longer too.
The novel dosage form for micro bubble echo contrast media not only simplifies the manipulation of echo contrast media and increases safety on use but, in particular, achieves a considerable additional gain in diagnostic information.

Claims (6)

1. Dosage form for micro bubble echo contrast media comprising a first syringe which is unreleasably connected to a mixing chamber which is provided in its 5 interior with mixing elements which, on operation of the syringe, bring about turbulence of the gaseous and liquid components of the contrast medium, the mixing chamber containing the predetermined amount, which is needed to produce the micro bubbles, of a suitable sterile gas and 10 being closed by a stopper or cap.
2. Dosage form according to claim 1, additionally comprising a second syringe.
3. Dosage form according to claim 2, characterised in that the second syringe contains the liquid contrast medium 15 component.
4. Dosage form according to claim 2, additionally comprising a vial containing the liquid contrast medium component.
5. Dosage form according to claim 1, characterised in that it is in the form of a set ready for use. 20
6. A dosage form substantially as hereinbefore described with reference to the accompanying drawings.
IE456391A 1990-12-28 1991-12-30 Preparation of Microbubble Echocontrast Agents IE69668B1 (en)

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IE69668B1 true IE69668B1 (en) 1996-10-02

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449350A (en) * 1994-07-19 1995-09-12 Abbott Laboratories Intravenous fluid administration device containing anti-squirting orifice flow control
DE4432993C1 (en) * 1994-09-16 1996-06-20 Byk Gulden Lomberg Chem Fab Mixing device for agents to be administered by means of a syringe
AU1545597A (en) * 1996-01-31 1997-08-22 Alfred Von Schuckmann Device for mixing air bubbles into an echo-contrast agent
US6042263A (en) * 1998-04-29 2000-03-28 Mentzer; Marvin R. Mixed phase ruff body flow diffuser
US6575930B1 (en) * 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
GB0028692D0 (en) 2000-11-24 2001-01-10 Btg Int Ltd Generation of therapeutic microform
DE10226803B4 (en) * 2001-06-19 2007-01-18 Chemische Fabrik Kreussler & Co. Gmbh Mixing device for the production of reproducible medical foam
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
DE20218493U1 (en) 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Device for producing medical foam
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
PT1694292E (en) 2003-11-17 2009-10-26 Btg Int Ltd Therapeutic foam comprising a sclerosing solution and a low quanitiy of gaseous nitrogen
JP4534123B2 (en) * 2003-12-26 2010-09-01 エス・ピー・ジーテクノ株式会社 Emulsion preparation device and method
US20050215954A1 (en) * 2004-03-29 2005-09-29 Mallinckrodt Inc. Apparatus and method for maintaining suspendible agents in suspension
DE102004048749B4 (en) * 2004-10-05 2007-03-29 Chemische Fabrik Kreussler & Co. Gmbh Device for producing a medical foam
DE102005011174B4 (en) 2005-03-09 2022-03-24 Chemische Fabrik Kreussler & Co. Gmbh Device for generating a medical foam
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
US20070244467A1 (en) * 2005-09-28 2007-10-18 Biodel, Inc., State Of Incorporation Delaware Self-Filling Two Chamber Injectable Device
US8257338B2 (en) * 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US20110021922A1 (en) * 2007-10-03 2011-01-27 Neorad As Monitoring the flow of fluid
CA2704012A1 (en) * 2007-11-08 2009-05-14 Nexmed Holdings, Inc. Device and system for mixing and dispensing components stored separately from one another
DE102009037765B4 (en) 2009-08-17 2011-12-29 Gottfried Hesse Method and device for producing a gas mixture
DE202010005131U1 (en) 2010-04-09 2011-08-30 Jakob Hoiss Apparatus for filling a syringe body with a gas mixture for subsequent injection of a mixture of the gas mixture and a medicament into the human or animal body
US10207053B2 (en) 2012-03-16 2019-02-19 Becton, Dickinson And Company Drug delivery device for drug suspensions
JP6755035B2 (en) * 2015-07-15 2020-09-16 国立大学法人 鹿児島大学 Bubble generation device and bubble generation method
CN107837439B (en) * 2017-12-15 2023-10-17 广东省人民医院(广东省医学科学院) Integrated replaceable injection tube radiography equipment
JP7190285B2 (en) * 2018-02-01 2022-12-15 聡 安斎 Microbubble generating method using infusion pack and microbubble generator for performing microbubble generating method
CN109260550A (en) * 2018-10-30 2019-01-25 北京大学深圳医院 Contrast agent microbubble vibrates infusing device
KR102215709B1 (en) 2019-03-26 2021-02-16 김성환 Syringe in which air bubbles in the cylinder are removed
CN112439330B (en) * 2019-08-30 2022-10-21 宁波方太厨具有限公司 Micro-nano bubble generating device and cleaning machine applying same
DE202020105691U1 (en) * 2020-10-05 2020-11-09 Scheugenpflug Gmbh One-piece static mixer
KR102537138B1 (en) * 2021-04-19 2023-05-26 경북대학교 산학협력단 Syringe used to inject anesthetics for framelink stereotatic surgery
KR102537121B1 (en) * 2021-04-19 2023-05-26 경북대학교 산학협력단 Syringe with length measuring device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5184456A (en) * 1975-01-21 1976-07-23 Reika Kogyo Kk Ryutaikakuhankongosochi
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
CH665127A5 (en) * 1983-12-02 1988-04-29 Debiopharm Sa COUPLING PART FOR INJECTION SYRINGES.
DE3520772A1 (en) * 1985-06-10 1986-12-11 INTERATOM GmbH, 5060 Bergisch Gladbach Mixing appliance
US4753536A (en) * 1987-03-09 1988-06-28 Spehar Edward R Dispensing mixer for the storage and mixing of separate materials
DE3838530A1 (en) * 1988-11-14 1990-05-17 Hilti Ag Packaging for two-component compounds

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WO1992011928A1 (en) 1992-07-23
HU216376B (en) 1999-06-28
DE59105805D1 (en) 1995-07-27
JP3637022B2 (en) 2005-04-06
EP0564505A1 (en) 1993-10-13
HUT65298A (en) 1994-05-02
AU9103391A (en) 1992-08-17
ZA9110191B (en) 1992-09-30
AR244998A1 (en) 1993-12-30
EP0564505B1 (en) 1995-06-21
RU2097014C1 (en) 1997-11-27
JP2002301150A (en) 2002-10-15
ATE123930T1 (en) 1995-07-15
CA2098710C (en) 2002-05-28
CA2098710A1 (en) 1992-06-29
ES2076739T3 (en) 1995-11-01
CZ126693A3 (en) 1993-11-17
NZ241212A (en) 1994-08-26
CZ283184B6 (en) 1998-01-14
DK0564505T3 (en) 1995-11-06
JP3325565B2 (en) 2002-09-17
KR930703066A (en) 1993-11-29
GR3017442T3 (en) 1995-12-31
JPH06503976A (en) 1994-05-12
IE914563A1 (en) 1992-07-01
KR100191689B1 (en) 1999-06-15
MX9102814A (en) 1994-03-31
DE4193414D2 (en) 1997-07-24
HU9301702D0 (en) 1993-09-28

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