IE65269B1 - Aromatase inhibitors - Google Patents
Aromatase inhibitorsInfo
- Publication number
- IE65269B1 IE65269B1 IE26391A IE26391A IE65269B1 IE 65269 B1 IE65269 B1 IE 65269B1 IE 26391 A IE26391 A IE 26391A IE 26391 A IE26391 A IE 26391A IE 65269 B1 IE65269 B1 IE 65269B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- aromatase
- pharmaceutical composition
- alkenyl
- carrier
- Prior art date
Links
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- 229940046844 aromatase inhibitors Drugs 0.000 title abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
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- 108010078554 Aromatase Proteins 0.000 claims abstract description 29
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 25
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 24
- 239000003085 diluting agent Substances 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 5
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
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- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/477,024 US5227375A (en) | 1990-02-08 | 1990-02-08 | Aromatase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE910263A1 IE910263A1 (en) | 1991-08-14 |
| IE65269B1 true IE65269B1 (en) | 1995-10-18 |
Family
ID=23894189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE26391A IE65269B1 (en) | 1990-02-08 | 1991-01-25 | Aromatase inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5227375A (enExample) |
| AU (1) | AU7150991A (enExample) |
| GR (1) | GR910100067A (enExample) |
| IE (1) | IE65269B1 (enExample) |
| IL (1) | IL97122A (enExample) |
| MY (1) | MY105479A (enExample) |
| NZ (1) | NZ236966A (enExample) |
| TW (1) | TW221418B (enExample) |
| WO (1) | WO1991012206A2 (enExample) |
| ZA (1) | ZA91604B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992017489A1 (fr) * | 1991-03-28 | 1992-10-15 | Teikoku Hormone Mfg. Co., Ltd. | Nouveau derive oxa- ou azasteroide |
| DE69324595T2 (de) * | 1992-09-30 | 1999-08-19 | Teikoku Hormone Mfg. Co. | 7-substituierte oxa-steroid verbindung |
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US5593987A (en) * | 1993-12-21 | 1997-01-14 | Eli Lilly And Company | Methods of inhibiting breast disorders |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6117429A (en) * | 1997-08-11 | 2000-09-12 | Weider Nutrition International, Inc | Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors |
| MXPA00008868A (es) | 1998-03-11 | 2003-04-25 | Endorech Inc | Inhibidores de dihidrogenasa de 17 -hidroxiesteroide y metodos para su uso. |
| EP1219631A4 (en) * | 1999-08-23 | 2003-03-19 | Chugai Pharmaceutical Co Ltd | ANTIANDROGEN ACTIVE SUBSTANCES |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| TW200401781A (en) * | 2002-03-22 | 2004-02-01 | Pharmacia Corp | C-17 spirolactonization and 6, 7 oxidation of steroids |
| RU2004131523A (ru) * | 2002-03-22 | 2005-06-10 | Фармация Корпорейшн (Us) | С-17-спиролактонизация и 6,7-окисление стероидов |
| PL376896A1 (pl) * | 2002-11-07 | 2006-01-09 | Pharmacia & Upjohn Company Llc | Sposoby wytwarzania 5-androstenów podstawionych w pozycji C-7 |
| EP1709062B9 (en) | 2004-01-16 | 2013-02-13 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
| BR112012029392A2 (pt) * | 2010-05-20 | 2017-07-11 | Univ Saskatchewan | uso d einibidores de aromatase para a sincronização da ovulação, indução da superovulação ou ovulação dupla e melhora da geminação e fertilidade em um mamífero |
| US10004723B2 (en) | 2013-04-19 | 2018-06-26 | University Of Saskatchewan | Aromatase inhibitor-releasing intravaginal device |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125071C (enExample) * | 1963-12-24 | |||
| US3380886A (en) * | 1965-04-07 | 1968-04-30 | Upjohn Co | 7alpha-methyl-3beta-hydroxy-5-androstenes |
| US3591607A (en) * | 1966-04-19 | 1971-07-06 | Hoffmann La Roche | Retrosteroid a-ring formation |
| US3766213A (en) * | 1966-04-19 | 1973-10-16 | Hoffmann La Roche | Retrosteroid a ring formation |
| US3485828A (en) * | 1967-04-10 | 1969-12-23 | Syntex Corp | 6,7-ethylene and 6,7-substituted ethylene derivatives of the pregnane series |
| US3952018A (en) * | 1972-01-14 | 1976-04-20 | Hoffmann-La Roche Inc. | 15-Oxasteroids |
| DE2558088C2 (de) * | 1975-12-19 | 1985-05-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten |
| DE3121153A1 (de) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "verwendung von aromatase-hemmern zur prophylaxe und therapie der prostatahyperplasie" |
| US4451404A (en) * | 1983-02-09 | 1984-05-29 | The Upjohn Company | 16β-Methyl steroid process |
| US4596796A (en) * | 1983-09-12 | 1986-06-24 | Sumitomo Chemical Company, Limited | Dithiolphosphoric acid ester as a soil pesticide |
| DE3612632A1 (de) * | 1986-04-11 | 1987-10-22 | Schering Ag | Verfahren zur herstellung von 7(alpha)-propylsteroiden |
| GB8617107D0 (en) * | 1986-07-14 | 1986-08-20 | Erba Farmitalia | 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives |
| GB8622330D0 (en) * | 1986-09-17 | 1986-10-22 | Erba Farmitalia | 4-substituted 6-alkylidenandrostene-3,17-dione derivatives |
-
1990
- 1990-02-08 US US07/477,024 patent/US5227375A/en not_active Expired - Fee Related
-
1991
- 1991-01-25 IE IE26391A patent/IE65269B1/en not_active IP Right Cessation
- 1991-01-28 ZA ZA91604A patent/ZA91604B/xx unknown
- 1991-01-31 NZ NZ236966A patent/NZ236966A/en unknown
- 1991-02-01 IL IL9712291A patent/IL97122A/en not_active IP Right Cessation
- 1991-02-04 AU AU71509/91A patent/AU7150991A/en not_active Abandoned
- 1991-02-04 WO PCT/CA1991/000033 patent/WO1991012206A2/en not_active Ceased
- 1991-02-07 GR GR910100067A patent/GR910100067A/el unknown
- 1991-02-08 MY MYPI91000193A patent/MY105479A/en unknown
- 1991-02-12 TW TW080101154A patent/TW221418B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991012206A2 (en) | 1991-08-22 |
| ZA91604B (en) | 1992-09-30 |
| MY105479A (en) | 1994-10-31 |
| IL97122A (en) | 1996-06-18 |
| WO1991012206A3 (en) | 1991-11-28 |
| NZ236966A (en) | 1993-11-25 |
| AU7150991A (en) | 1991-09-03 |
| TW221418B (enExample) | 1994-03-01 |
| US5227375A (en) | 1993-07-13 |
| IE910263A1 (en) | 1991-08-14 |
| IL97122A0 (en) | 1992-05-25 |
| GR910100067A (el) | 1992-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |