IE56855B1 - Physiologically tolerable metal complex salts for use in diagnosis - Google Patents

Physiologically tolerable metal complex salts for use in diagnosis

Info

Publication number
IE56855B1
IE56855B1 IE126/84A IE12684A IE56855B1 IE 56855 B1 IE56855 B1 IE 56855B1 IE 126/84 A IE126/84 A IE 126/84A IE 12684 A IE12684 A IE 12684A IE 56855 B1 IE56855 B1 IE 56855B1
Authority
IE
Ireland
Prior art keywords
hollow
union
sleeve
body part
radiator
Prior art date
Application number
IE126/84A
Other versions
IE840126L (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6189163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE56855(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Priority to IE169/89A priority Critical patent/IE56857B1/en
Publication of IE840126L publication Critical patent/IE840126L/en
Publication of IE56855B1 publication Critical patent/IE56855B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Paper (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Forging (AREA)

Abstract

Physiologically tolerable complex salts which contain (a) a central element selected from elements having atomic numbers from 21 to 29, 42, 44 and from 58 to 70, and (b) a radical of a physiologically-tolerable complex-forming acid and, if desired, (c) a radical selected from radicals of inorganic and organic bases and amino acids, and their use in NMR diagnosis.

Description

THE INVENTION relates to a method of producing a union for the flow and return pipes of panel radiators, the union comprising a substantially spherical hollow body having a pipe connection sleeve which merges into the & interior of the hollow body, the same being formed perpendicularly to such sleeve with a connection aperture for the radiator.
A wide variety of angle unions for this purpose are known. Since in practice they are required in very large numbers, they are definitely mass-produced articles. The basic trend with mass-produced articles is to keep the cost per unit very low by using as little material as possible and by making the production method as simple as possible.
Because of the consistent operation of such unions, there are relatively narrow limits to their construction.
The main consideration is therefore less their external appearance than the method of their production.
A known production method comprises the following steps: (a) upsetting a tubular member in a mould to form a hollow-body part merging into a neck part centred on a longitudinal axis of the tubular member, the M hollow-body part having an aperture, centred on said longitudinal axis, at the end of the upset -2tubular member remote from the neck part? (b) Welding on a sheet-metal round to close said aperture in the hollow-body part which is remote from the neck part, and (c) Forming the pipe connection sleeve and contriving a bore in the hollow-body part.
Such a method is herein referred to as being of the kind specified.
In a known method of the kind specified, after the round has been welded on fo close one opening of the hollow-body part, a prefabricated pipe-connection sleeve ls welded onto the hollow-body part so that said sleeve extends perpendicular fo the longitudinal axis of the upset tubular member. That part of the hollow-body part which is encircled by the end of said sleeve which is welded fo the hollow body part is then drilled through so that the bore thus formed in the wall of the hollow body member forms a continuation of the inferior surface of said sleeve. Said bore and the interior of the sleeve are then formed with an internal screwthread. The neck part of this union is relatively short and forms the opening for the connection of the radiator. The weldedon round, which enables the overall height of the union fo be relatively reduced, is operative in the subsequent fitting of the union to the radiator as an abutment surface for a press-welding electrode.
This known method of producing angle unions of the kind specified is elaborate because the pipe connection sleeve must be prefabricated in a separate operation, then welded to the hollow body part. Separate prefabrication and more particularly the welding of the sleeve are relatively costly. In the known method the -2awall of the hollow body must then be drilled through in the zone surrounded by the welded-on sleeve, which causes additional difficulty.
It is an object of the invention so to develop a method of the kind specified that not only are at least some of tne steps of the method simplified but also fewer steps are necessary overall while consumption of material is much reduced.
According to the invention, there is provided a method of producing a union for the flow and return pipes of panel radiators, the union comprising a substantially spherical hollow body having a pipe connection sleeve which merges into the interior of the hollow body, the same being formed perpendicularly to such sleeve with a connection aperture for the radiator, the method comprising the steps of: (a) upsetting a tubular member in a mould to fora a hollow-body part merging into a neck part; (b) welding on a sheet-metal round to close that aperture in the hollow-body part which is remote from the neck part, and (c) forming the pipe connection sleeve and contriving a bore in the hollovj-body part, i -3ond wherein the neck part is the pipe connection sleeve and the bore in the hollow-body port is the opening for connection of the radiator.
Whereas in the known method the relatively short neck part will subsequently be the opening for the connection of the radiator, in the method according to the invention the neck part is used to form the pipe connection sleeve. The advantage is that not only is prefabrication of a y separate sleeve for each union eliminated but also the very time-consuming and expensive step of welding the sleeve to the hallow-body part is * 10 eliminated. Whereas in the known method the hollow-body part must be drilled in the zone of the welded-on sleeve, in the method according to the invention the hollow-body port can be drilled at an exposed place relatively cheaply.
Th^ method is greatly simplified because only a single part in addition to the metal round is processed throughout the complete procedure.
In a further development of the invention, to form the electrode engagement surface known in connection with such unions the hollow-body part is faceted by a stamping step on the side opposite the place intended for the radiator connection aperture» Whereas in the union produced by the known method the metal round forms the engagement surface for the welding electrode, in the angle union produced by the preferred method embodying the invention such surface is embodied by the faceted or flattened (lateral) port of the hollow-body part. Preferably, the faceting stop is performed after the aperture in the upset tubular member has been closed by welding.
An embodiment of the invention is described below by way of example with reference to the accompanying drawings wherein: FIGURE I is a sectioned view through part of a panel radiator with an angle union secured to it; FIGURE 2 is o diagrammatic plan view corresponding to Figure I, and J FIGURES 3 to 8 are sectioned views of partly machined articles, the end product being the angle union shown in Figure 8. -4Figure I shows a part of a panel radiator P which is formed with a flow opening Z. Diposed between the two parallel panels of the radiator P near the opening Z is a bearing part S which is of aa further interest in the present connection and which is operative to prevent the two panels of the radiator P being squeezed together.
An angle union 100 is press welded to opening Z, a centering collar of the part S extending through the opening Z into the union IQQ.
The union 100 has a pipe connection sleeve 2 formed with an internal screwthread 6. Opposite the sleeve 2, interior 4 of the hollow body is closed at the bottom by a base 3, On that side of the interior 4 which is opposite the opening Z the union 100 has o facet 5 whose exterior is engaged by on electrode for press welding. The other electrode is applied to the outside of the radiator P opposite the face? 5, On the side opposite the facet 5 the interior 4 is formed with a radiator connection opening 7 into which the centering collar of the port S extends.
Figure 2 is a pion view corresponding to Figure I· The sleeve 2 con, of course, extend downwardly or in some other direction from that shown.
A description will now be given with reference to Figures 3 to 8 of 25 the method of producing th® union 100. First, o tubular member 10 of the required length is parted off from a tube» The member 10 is formed with a left opening IQa ond a right opening 10b (Figure 3).
The elongated tubular member 10 is then upset in known manner by 30 means of a special mould so that it acquires the shape shown in Figure 4. The upset tubular member 20 which is shown in Figure 4 and in which there is a left opening 20a and a right opening 20b has a neck part 21, which widens near the left opening 20a, and a spherical hollow-body part 22. The upsetting step bevels the right opening 20b of the upset member 20 so that a sheet metal round 3 shown in Figure 5 can readily be welded subsequently into the opening 20b, prefereably by resistance welding, to close the opening. -5The round 3 is virtually the only separote required for the production of the union in addition to the tubular member.
After the round 3 has been welded in, dished member 30 as shown in Figure 6 exists. On one side of the hollow-body port 22 a facet $ is formed. The facet is contrived by stamping. The facet 5 is operative fo receive a welding electrode in the subsequent step of welding the union fo a radiator, for example, by resistance welding.
The inferior of the sleeve 2 is in known manner formed with an infernal screwthread 6 (Figure 8). Also, that side of the hollow-body part 22 which is opposite the facet 5 is drilled and provided with bevelling fo leave the radiator connection opening 7. The union 100 is then complete.

Claims (6)

1. A method of producing a union for the flow and return pipes of panel radiators, the union comprising a substantially spherical hollow-body having a pipe connection sleeve which merges into the interior of the hollow-body, the same being formed perpendicularly to such sleeve with a connection aperture for the radiator, the method comprising the steps of: (a) upsetting a tubular member in a mould to form a hollow-body part merging into a neck part; (b) welding on a sheet-metal round to close that aperture in the hollow-body part which is remote from the neck part, and (c) forming the pipe connection sleeve and contriving a bore in the hollow-body part, and wherein the neck part is the pipe connection sleeve and the bore in the hollow-body part is the opening for connection of the radiator.
2. A method according to claim 1 wherein the neck part is formed with an internal screw thread.
3. A method according to claim 1 in which the hollowbody part is faceted by a stamping step on the side opposite the place intended for the radiator connection aperture. I - 7
4. A method according to claim 2 in which the stamping step precedes the steps of forming the pipe connection sleeve and contriving said bore in the hollow-body part o
5. A method of producing a union, substantially as b hereinbefore described with reference to the accompanying drawings·
6. A union produced by the method of any of claims 1 to 5.
IE126/84A 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in diagnosis IE56855B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE169/89A IE56857B1 (en) 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in nmr diagnosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3302410 1983-01-21
IE169/89A IE56857B1 (en) 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in nmr diagnosis

Publications (2)

Publication Number Publication Date
IE840126L IE840126L (en) 1984-07-21
IE56855B1 true IE56855B1 (en) 1992-01-01

Family

ID=6189163

Family Applications (2)

Application Number Title Priority Date Filing Date
IE169/89A IE56857B1 (en) 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in nmr diagnosis
IE126/84A IE56855B1 (en) 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in diagnosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE169/89A IE56857B1 (en) 1983-01-21 1984-01-20 Physiologically tolerable metal complex salts for use in nmr diagnosis

Country Status (23)

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JP (2) JPH0772162B2 (en)
AT (1) AT397465B (en)
AU (2) AU574658B2 (en)
BE (1) BE898708A (en)
CA (1) CA1256249A (en)
CH (1) CH660183A5 (en)
DE (1) DE3401052C2 (en)
DK (2) DK170460B1 (en)
ES (1) ES8504668A1 (en)
FI (1) FI79026C (en)
FR (2) FR2539996B1 (en)
GB (3) GB2137612A (en)
GR (1) GR81653B (en)
IE (2) IE56857B1 (en)
IL (2) IL70711A (en)
IT (1) IT1213128B (en)
LU (1) LU85177A1 (en)
NL (2) NL194579C (en)
NO (1) NO169103C (en)
NZ (2) NZ206868A (en)
PT (1) PT77983B (en)
SE (2) SE510582C2 (en)
ZA (1) ZA84472B (en)

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