DK25484D0 - DIAGNOSTIC AGENT - Google Patents

DIAGNOSTIC AGENT

Info

Publication number
DK25484D0
DK25484D0 DK0254/84A DK25484A DK25484D0 DK 25484 D0 DK25484 D0 DK 25484D0 DK 0254/84 A DK0254/84 A DK 0254/84A DK 25484 A DK25484 A DK 25484A DK 25484 D0 DK25484 D0 DK 25484D0
Authority
DK
Denmark
Prior art keywords
diagnostic agent
diagnostic
agent
Prior art date
Application number
DK0254/84A
Other languages
Danish (da)
Other versions
DK170460B1 (en
DK25484A (en
Inventor
Heinz Gries
Douwe Rosenberg
Hans-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6189163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK25484(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK25484D0 publication Critical patent/DK25484D0/en
Publication of DK25484A publication Critical patent/DK25484A/en
Application granted granted Critical
Publication of DK170460B1 publication Critical patent/DK170460B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Forging (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Paper (AREA)
DK025484A 1983-01-21 1984-01-20 Diagnostic agent for use in in vivo NMR diagnostics, method of preparation thereof and complex salts suitable for use in the diagnostic agent DK170460B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3302410 1983-01-21
DE3302410 1983-01-21

Publications (3)

Publication Number Publication Date
DK25484D0 true DK25484D0 (en) 1984-01-20
DK25484A DK25484A (en) 1984-07-22
DK170460B1 DK170460B1 (en) 1995-09-11

Family

ID=6189163

Family Applications (2)

Application Number Title Priority Date Filing Date
DK025484A DK170460B1 (en) 1983-01-21 1984-01-20 Diagnostic agent for use in in vivo NMR diagnostics, method of preparation thereof and complex salts suitable for use in the diagnostic agent
DK089794A DK170461B1 (en) 1983-01-21 1994-08-01 Diagnostic agent for use in in vivo NMR diagnostics, method of preparation thereof and complex salts suitable for use in the diagnostic agent

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK089794A DK170461B1 (en) 1983-01-21 1994-08-01 Diagnostic agent for use in in vivo NMR diagnostics, method of preparation thereof and complex salts suitable for use in the diagnostic agent

Country Status (23)

Country Link
JP (2) JPH0772162B2 (en)
AT (1) AT397465B (en)
AU (2) AU574658B2 (en)
BE (1) BE898708A (en)
CA (1) CA1256249A (en)
CH (1) CH660183A5 (en)
DE (1) DE3401052C2 (en)
DK (2) DK170460B1 (en)
ES (1) ES8504668A1 (en)
FI (1) FI79026C (en)
FR (2) FR2539996B1 (en)
GB (3) GB2137612A (en)
GR (1) GR81653B (en)
IE (2) IE56855B1 (en)
IL (2) IL77761A (en)
IT (1) IT1213128B (en)
LU (1) LU85177A1 (en)
NL (2) NL194579C (en)
NO (1) NO169103C (en)
NZ (2) NZ219079A (en)
PT (1) PT77983B (en)
SE (2) SE510582C2 (en)
ZA (1) ZA84472B (en)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324235A1 (en) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen NEW COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS
US5720939A (en) * 1985-08-15 1998-02-24 Nycomed Imaging As Method of contrast enhanced magnetic resonance imaging using magnetically responsive-particles
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
ZA852979B (en) * 1984-04-27 1985-11-27 Vestar Research Inc Contrast agents for nmr imaging
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
DE3577550D1 (en) * 1984-09-21 1990-06-13 Dow Chemical Co AMINOCARBONIC ACID COMPLEXES FOR TREATING BONE TUMORS.
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
CA1317937C (en) * 1984-10-18 1993-05-18 A. Dean Sherry Gadolinium chelates with carboxymethyl derivatives of polyazamacrocycles as nmr contrast agents
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5188816A (en) * 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
EP0184899B1 (en) * 1984-11-01 1990-04-18 Nycomed As Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation
SE465907B (en) * 1984-11-01 1991-11-18 Nyegaard & Co As DIAGNOSTIC AGENT CONTENT AND PARAMAGNETIC METAL
DE3508000A1 (en) * 1985-03-04 1986-09-04 Schering AG, Berlin und Bergkamen, 1000 Berlin Ferromagnetic particles for NMR diagnosis
DE3443252A1 (en) * 1984-11-23 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Dextran-magnetite complexes for NMR diagnosis
DE3443251C2 (en) * 1984-11-23 1998-03-12 Schering Ag Iron oxide complexes for NMR diagnosis, diagnostic compounds containing these compounds, their use and process for their preparation
US4758422A (en) * 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
US4980148A (en) * 1985-02-06 1990-12-25 Mallinckrodt, Inc. Methods for enhancing magnetic resonance imaging
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
GB8518300D0 (en) * 1985-07-19 1985-08-29 Amersham Int Plc Contrast agent
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
MX174467B (en) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODO DECAN SUBSTITUTE IN 1 AND ANALOG COMPOUNDS
WO1987006139A1 (en) * 1986-04-07 1987-10-22 Dietlin Francois New compositions usable in tomo-densitometry
FR2596992B1 (en) * 1986-04-11 1988-12-16 Guerbet Sa GYSOLINIUM-DOTA COMPLEX LYSINE SALT AND ITS APPLICATIONS TO DIAGNOSIS
EP0250358A3 (en) * 1986-06-20 1988-10-05 Schering Aktiengesellschaft Novel complex compounds
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
AU608759B2 (en) * 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
US5252317A (en) * 1986-11-10 1993-10-12 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
US5135737A (en) * 1986-11-10 1992-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
US4863717A (en) * 1986-11-10 1989-09-05 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
US5567411A (en) * 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
DE3640708C2 (en) * 1986-11-28 1995-05-18 Schering Ag Improved pharmaceuticals containing metals
IT1224416B (en) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa MACROCYCLIC CHELANTS AND THEIR CHELATES
FI80801C (en) * 1987-01-14 1990-07-10 Innofarm Oy KJJUGAT AV EN MONOCLONAL ANTIKROPP OCH ANVAENDNING. ELLER ETT FRAGMENT DAERAV OCH ETT KELATERANDE AEMNE, DESS FRAMSTAELLNING
GB8701054D0 (en) * 1987-01-16 1987-02-18 Amersham Int Plc Contrast agent for nmr scanning
FR2612400A1 (en) * 1987-03-16 1988-09-23 Centre Nat Rech Scient Microcapsules containing a radioactive and/or paramagnetic label in chelate form, and their use in the field of medical imaging
DE3709851A1 (en) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te NMR DIAGNOSTIC LIQUID COMPOSITIONS
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
DE3710730A1 (en) * 1987-03-31 1988-10-20 Schering Ag SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5693309A (en) * 1987-03-31 1997-12-02 Schering Aktiengesellschaft Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same
US5482700A (en) * 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
FR2614020B1 (en) * 1987-04-14 1989-07-28 Guerbet Sa NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY SUCH LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR PREPARING LIGANDS.
DE3713842A1 (en) * 1987-04-22 1988-11-17 Schering Ag SUBSTITUTED CYCLIC COMPLEX MAKERS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
JP2690987B2 (en) * 1987-06-23 1997-12-17 ハフスルンド・ニユコメド・イノベイション・アクチェボラーグ Improvements in magnetic resonance imaging
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
WO1989000557A1 (en) * 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Aminopolycarboxylic acids and derivatives thereof
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
JP2520262B2 (en) * 1987-08-21 1996-07-31 春幸 川原 Patch test material
DE3728525A1 (en) * 1987-08-24 1989-03-16 Schering Ag MULTI-CORE SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
DE3927444A1 (en) * 1989-08-16 1991-02-28 Schering Ag USE OF AMID COMPLEX COMPOUNDS
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
DE3806795A1 (en) * 1988-02-29 1989-09-07 Schering Ag POLYMER-TIED COMPLEX IMAGERS, THEIR COMPLEXES AND CONJUGATES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THEM
DE3809671A1 (en) * 1988-03-18 1989-09-28 Schering Ag PORPHYRINE COMPLEX COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
DE4001655A1 (en) * 1990-01-18 1991-07-25 Schering Ag 6-RING MACROCYCLIC TETRAAZA COMPOUNDS, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PRODUCTS CONTAINING THEM
DE3825040A1 (en) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- OR 6-RING MACROCYCLIC POLYAZA COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
EP0354543B1 (en) * 1988-08-08 1992-11-11 Biomira, Inc. Photochemical attachment of chelating groups to biomolecules
IE66694B1 (en) * 1988-09-27 1996-01-24 Nycomed Salutar Inc Chelate compositions
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
US5213788A (en) * 1988-09-29 1993-05-25 Ranney David F Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
US6139603A (en) * 1989-02-22 2000-10-31 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for recovering oxygen
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
DE3922005A1 (en) * 1989-06-30 1991-01-10 Schering Ag DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
EP0490897A1 (en) * 1989-09-05 1992-06-24 Mallinckrodt, Inc. Novel magnetic resonance imaging agents
US5516503A (en) * 1989-11-16 1996-05-14 Guerbet S.A. Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging
FR2654344B1 (en) * 1989-11-16 1994-09-23 Cis Bio Int GADOLINIUM PARAMAGNETIC COMPLEX, ITS PREPARATION METHOD AND ITS USE FOR MRI DIAGNOSIS.
DE3938992A1 (en) * 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
JP3131219B2 (en) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト Chelate compounds
IE912054A1 (en) * 1990-06-18 1991-12-18 Dow Chemical Co The use of macrocyclic aminophosphonic acid complexes as¹imaging agents
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
WO1993003351A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Amino acid, ester and/or catechol contrast agents for mri
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
DE4317588C2 (en) * 1993-05-24 1998-04-16 Schering Ag Macrocyclic metal complexes containing fluorine, process for their preparation and their use
DE4318369C1 (en) * 1993-05-28 1995-02-09 Schering Ag Use of macrocyclic metal complexes as temperature probes
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
DE4340809C2 (en) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-tetraazacyclododecane derivatives, pharmaceutical compositions containing them and process for their preparation
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
DE19500665A1 (en) * 1995-01-12 1996-07-18 Axel Prof Dr Haase Process for the spatially resolving imaging of an area of a biological object with the help of electromagnetic rays using contrast media
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
DE19507819A1 (en) * 1995-02-21 1996-08-22 Schering Ag New di:ethylene-tri:amine penta:acetic acid amide complexes
DE19505960A1 (en) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Conjugate for the individual dosage of drugs
DE19507820A1 (en) * 1995-02-21 1996-08-22 Schering Ag Novel substituted DTPA derivatives, their metal complexes, pharmaceutical compositions containing these complexes, their use in diagnostics, and methods for producing the complexes and compositions
DE19507822B4 (en) * 1995-02-21 2006-07-20 Schering Ag Substituted DTPA monoamides of the central carboxylic acid and its metal complexes, pharmaceutical compositions containing these complexes, their use in diagnostics and therapy, and methods for the preparation of the complexes and agents
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
EP1060174B1 (en) * 1997-12-23 2004-09-22 Amersham Health AS Nitric oxide releasing chelating agents and their therapeutic use
IT1297035B1 (en) 1997-12-30 1999-08-03 Bracco Spa 1,4,7,10-TETRAAZACICLODODECAN-1,4-DIACETIC ACID DERIVATIVES
IT1315263B1 (en) * 1999-12-21 2003-02-03 Bracco Spa CHELATING COMPOUNDS, THEIR CHELATES WITH PARAMAGNETIC METAL IONS, THEIR PREPARATION AND USE
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
US8669236B2 (en) 2005-05-12 2014-03-11 The General Hospital Corporation Biotinylated compositions
WO2008091349A1 (en) * 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
AU2007248656B2 (en) 2006-05-03 2013-04-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase and tubulin deacetylase inhibitors
DE102007002726A1 (en) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft New cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them
DE102007058220A1 (en) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft New metal complexes useful e.g. for manufacturing agent for X-ray diagnostics and magnetic resonance tomography-diagnostics of brain infarcts and liver tumor, and/or space-process in liver and abdomen tumors and musculoskeletal tumors
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
JP5397976B2 (en) * 2008-05-07 2014-01-22 公立大学法人大阪府立大学 Paramagnetic metal-containing polyamidoamine dendron lipids
KR101708946B1 (en) 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. Deacetylase inhibitors and uses thereof
FR2945448B1 (en) * 2009-05-13 2012-08-31 Guerbet Sa PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL FORMULATION OF LANTHANIDE CHELATE AS A POWDER
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
EP2338874A1 (en) * 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
WO2012143355A1 (en) 2011-04-21 2012-10-26 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
EP3441467A3 (en) 2012-08-31 2019-04-24 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1070695A (en) * 1975-09-02 1980-01-29 Michael D. Loberg Iminodiacetic acid pharmaceutical
US4176173A (en) * 1977-07-18 1979-11-27 Medi-Physics, Inc. Radiographic compositions
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
DE3033651A1 (en) * 1980-09-06 1982-03-25 Wilhelm Bögle KG, 7410 Reutlingen HOLDING DEVICE FOR FABRIC-COVERED PANELED WALLS
DE3038853A1 (en) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW N-HYDROXY-ALKYLATED DICARBONIC ACID-BIS- (3,5-DICARBAMOYL-2,4,6-TRIJODANILIDES), THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRAST AGENTS (II)
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
DE3129906C3 (en) * 1981-07-24 1996-12-19 Schering Ag Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging

Also Published As

Publication number Publication date
DK170461B1 (en) 1995-09-11
PT77983A (en) 1984-02-01
AU2355984A (en) 1984-07-26
FI840226A0 (en) 1984-01-19
NL194579C (en) 2002-08-05
FR2590484A1 (en) 1987-05-29
JP2556627B2 (en) 1996-11-20
AU574658B2 (en) 1988-07-14
GB8529903D0 (en) 1986-01-15
IE840126L (en) 1984-07-21
LU85177A1 (en) 1984-05-24
GR81653B (en) 1984-12-12
IL70711A (en) 1988-12-30
DE3401052C2 (en) 2001-05-23
FI840226A (en) 1984-07-22
FI79026C (en) 1989-11-10
IT8419241A0 (en) 1984-01-19
GB2169599A (en) 1986-07-16
IE56857B1 (en) 1992-01-01
NO169103C (en) 1992-05-13
PT77983B (en) 1986-04-10
DK89794A (en) 1994-08-01
ATA19184A (en) 1993-09-15
GB8529901D0 (en) 1986-01-15
AT397465B (en) 1994-04-25
JPH04217927A (en) 1992-08-07
ES529020A0 (en) 1985-05-16
FR2590484B1 (en) 1989-03-31
NL8400079A (en) 1984-08-16
SE510582C2 (en) 1999-06-07
NZ219079A (en) 1988-08-30
ZA84472B (en) 1984-08-29
IE890169L (en) 1984-07-21
NL194579B (en) 2002-04-02
IT1213128B (en) 1989-12-14
SE8400254L (en) 1984-07-22
FR2539996A1 (en) 1984-08-03
GB2169598B (en) 1987-09-23
DK170460B1 (en) 1995-09-11
DE3401052A1 (en) 1984-07-26
DK25484A (en) 1984-07-22
NO840223L (en) 1984-07-23
GB2169599B (en) 1987-09-09
SE512863C2 (en) 2000-05-22
SE8400254D0 (en) 1984-01-19
IL77761A (en) 1988-12-30
GB2137612A (en) 1984-10-10
NO169103B (en) 1992-02-03
SE9301557D0 (en) 1993-05-06
AU1018488A (en) 1988-04-28
FI79026B (en) 1989-07-31
NL195071C (en) 2003-07-08
ES8504668A1 (en) 1985-05-16
NZ206868A (en) 1988-08-30
AU607456B2 (en) 1991-03-07
IE56855B1 (en) 1992-01-01
CH660183A5 (en) 1987-03-31
FR2539996B1 (en) 1987-11-06
SE9301557L (en) 1900-01-01
GB8401486D0 (en) 1984-02-22
NL9900020A (en) 2002-07-01
GB2169598A (en) 1986-07-16
BE898708A (en) 1984-05-16
JPH0772162B2 (en) 1995-08-02
JPS59139390A (en) 1984-08-10
CA1256249A (en) 1989-06-20

Similar Documents

Publication Publication Date Title
DK25484D0 (en) DIAGNOSTIC AGENT
NO854349L (en) DIAGNOSTIC AGENT.
DK345684D0 (en) ANALGETIC AGENT
DK162816C (en) MEDICAL ELECTRODUCT
FR2548009B1 (en) SPHYGMOMANOMETER
DK166128C (en) NMR contrast agent
IT1181465B (en) SURGICAL MICROPINZA
IT1181815B (en) ELECTROCARDIOGRAPH
DK437885A (en) ANTI-FRESHING AGENT
ATA903584A (en) SNOWROOM UNIT
DE3484390D1 (en) CONTRAST AGENTS.
DK103783D0 (en) TOPIC AGENT
DK203482A (en) COSMETIC AGENT
FR2499416B1 (en) HEMOSTATIC CUSHION
DK548884D0 (en) ANTHELMINTIC AGENT
DK24285D0 (en) FUNGICID AGENT
DK646487D0 (en) FOOD-INFECTING AGENT
FI834542A0 (en) DIAGNOSTIC TYPE
DE3461472D1 (en) ORGANOCLAY-ANTIOZONANT COMPLEX
IT1175495B (en) C-NITROSOARILAMINE REDUCTION PROCEDURE
DK285384D0 (en) SELECTIVE HERBICID AGENT
BR8301344A (en) DISPOSABLE TYPE
IT8349247A0 (en) SINGLE HEALTH
DK183483D0 (en) DISPOSABLE FUNNY
DK444083D0 (en) STETHOSCOPE

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired