IE45671L - D-homosteroids - Google Patents

D-homosteroids

Info

Publication number
IE45671L
IE45671L IE771800A IE180077A IE45671L IE 45671 L IE45671 L IE 45671L IE 771800 A IE771800 A IE 771800A IE 180077 A IE180077 A IE 180077A IE 45671 L IE45671 L IE 45671L
Authority
IE
Ireland
Prior art keywords
homosteroid
formula
fluorine
denotes
chlorine
Prior art date
Application number
IE771800A
Other versions
IE45671B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE45671L publication Critical patent/IE45671L/en
Publication of IE45671B1 publication Critical patent/IE45671B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Anti-inflammatory D-homosteroids of the formula <IMAGE> in which the dotted 1,2 bond denotes an optional C-C bond; R<6> denotes hydrogen, fluorine, chlorine or methyl; R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha . [GB1586504A]
IE1800/77A 1976-09-03 1977-08-29 D-homosteroids IE45671B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT656076A AT356301B (en) 1976-09-03 1976-09-03 METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS

Publications (2)

Publication Number Publication Date
IE45671L true IE45671L (en) 1978-03-03
IE45671B1 IE45671B1 (en) 1982-10-20

Family

ID=3587531

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1800/77A IE45671B1 (en) 1976-09-03 1977-08-29 D-homosteroids

Country Status (30)

Country Link
JP (1) JPS5910680B2 (en)
AR (1) AR220320A1 (en)
AT (1) AT356301B (en)
AU (1) AU516174B2 (en)
BE (1) BE858354A (en)
CA (1) CA1098897A (en)
CH (4) CH629827A5 (en)
DE (1) DE2738363A1 (en)
DK (1) DK140947B (en)
ES (3) ES462076A1 (en)
FI (1) FI57600C (en)
FR (1) FR2363580A1 (en)
GB (1) GB1586504A (en)
GR (1) GR73039B (en)
HK (1) HK26484A (en)
HU (2) HU184769B (en)
IE (1) IE45671B1 (en)
IL (1) IL52831A (en)
IT (1) IT1085032B (en)
LU (1) LU78064A1 (en)
MC (1) MC1166A1 (en)
MY (1) MY8500293A (en)
NL (1) NL182314C (en)
NO (1) NO145621C (en)
NZ (1) NZ185046A (en)
PH (1) PH14434A (en)
PT (1) PT66983B (en)
SE (1) SE440783B (en)
YU (2) YU40009B (en)
ZA (1) ZA775192B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1188616A (en) * 1981-06-11 1985-06-11 Hoffmann-La Roche Limited Pharmaceutical preparations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH571018A5 (en) * 1972-03-29 1975-12-31 Hoffmann La Roche
DK142289B (en) * 1973-03-28 1980-10-06 Hoffmann La Roche Analogous procedure for the preparation of D-homopregn-4-ene-3,20-dione.
DE2349023A1 (en) * 1973-09-26 1975-04-10 Schering Ag NEW D-HOMO-STEROIDS
CH601351A5 (en) * 1973-09-26 1978-07-14 Hoffmann La Roche
DE2349022A1 (en) * 1973-09-26 1975-04-10 Schering Ag NEW D-HOMO-STEROIDS
DE2442615A1 (en) * 1974-09-04 1976-03-18 Schering Ag NEW D-HOMO-STEROIDS

Also Published As

Publication number Publication date
SE7709916L (en) 1978-03-04
AR220320A1 (en) 1980-10-31
JPS5910680B2 (en) 1984-03-10
FI57600B (en) 1980-05-30
CA1098897A (en) 1981-04-07
GB1586504A (en) 1981-03-18
NL7709585A (en) 1978-03-07
NZ185046A (en) 1980-10-08
DK393277A (en) 1978-03-04
IE45671B1 (en) 1982-10-20
PT66983B (en) 1979-09-12
MC1166A1 (en) 1978-06-02
NO145621C (en) 1982-04-28
DE2738363C2 (en) 1988-01-14
AT356301B (en) 1980-04-25
HU184769B (en) 1984-10-29
IL52831A0 (en) 1977-10-31
FI57600C (en) 1980-09-10
IT1085032B (en) 1985-05-28
ES469574A1 (en) 1978-12-01
NO773057L (en) 1978-03-06
AU516174B2 (en) 1981-05-21
BE858354A (en) 1978-03-02
FR2363580B1 (en) 1980-01-18
DK140947B (en) 1979-12-10
YU200977A (en) 1983-02-28
ES469573A1 (en) 1978-12-01
ZA775192B (en) 1978-07-26
NO145621B (en) 1982-01-18
SE440783B (en) 1985-08-19
PH14434A (en) 1981-07-16
DK140947C (en) 1980-05-27
ATA656076A (en) 1979-09-15
NL182314B (en) 1987-09-16
LU78064A1 (en) 1978-10-17
ES462076A1 (en) 1978-11-01
HK26484A (en) 1984-03-30
CH629827A5 (en) 1982-05-14
JPS5331655A (en) 1978-03-25
MY8500293A (en) 1985-12-31
NL182314C (en) 1988-02-16
YU40009B (en) 1985-06-30
AU2830477A (en) 1979-03-08
CH629830A5 (en) 1982-05-14
YU40089B (en) 1985-06-30
CH629828A5 (en) 1982-05-14
YU227782A (en) 1983-02-28
DE2738363A1 (en) 1978-03-16
CH629829A5 (en) 1982-05-14
IL52831A (en) 1982-04-30
PT66983A (en) 1977-10-01
GR73039B (en) 1984-01-26
HU176255B (en) 1981-01-28
FI772599A7 (en) 1978-03-04
FR2363580A1 (en) 1978-03-31

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