IE44770B1 - Improvements in and relating to compositions for topical application - Google Patents
Improvements in and relating to compositions for topical applicationInfo
- Publication number
- IE44770B1 IE44770B1 IE241/77A IE24177A IE44770B1 IE 44770 B1 IE44770 B1 IE 44770B1 IE 241/77 A IE241/77 A IE 241/77A IE 24177 A IE24177 A IE 24177A IE 44770 B1 IE44770 B1 IE 44770B1
- Authority
- IE
- Ireland
- Prior art keywords
- weight
- glutaraldehyde
- water
- composition according
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1522551 Compositions containing glutaraldehyde DERMAL LABORATORIES Ltd 4 Feb 1977 [5 Feb 1976] 04570/76 Heading A5B A composition for removing warts comprises in a single phase from 1-25% by weight of glutaraldehyde, from 50-98% by weight of volatile, organic solvents of from 1-4 carbon atoms capable of, forming a hydrogen bond with water or glutaraldehyde, and from 1-45% by weight of water, in which the percentage by weight of glutaraldehyde is at least 1/9 of, but not more than equal to, the percentage by weight of water, the percentages being based on the combined weight of glutaraldehyde, solvent(s) and water, and the pH of the composition being from 3.5 to 7.0. The organic solvent may suitably be acetone or an alkanol.
Description
This invention relates to compositions for topical application to the skin, and to their use, especially in the removal of warts.
The presence of warts on the skin, while normally 5 painless and non-injurious to the person suffering from . them (although planter warts can be very painful), can be very disfiguring, especially when the warts are in a prominent or cosmetically important place. There is, therefore, a need for a method for removing warts which is simple, reliable, and harmless to the person having the wart. Recent work has shown that glutaraldehyde in aqueous solution can be used effectively to remove warts. The solution, normally containing 10%'to 25% by weight of glutaraldehyde in water and containing sufficient sodium , bicarbonate to bring the pH to 7.5, is applied repeatedly to the wart and after a few weeks the latter is removed. .
This method, while effective, suffers from certain disadvantages. In the first place, it is difficult to apply the solution only to the wart, and, since glutaraldehyde produces a brown stain on normal skin, this means that the area surrounding the wart is normally stained while treatment is going on, which can be a considerable disadvantage to the person being treated.· Secondly, after the solution has been applied, it is necessary to wait until it dries in order that it should not get rubbed off, and this means that the period of time required for application is inconveniently prolonged. Thirdly, the solution of glutaraldehyde, if concentrated, is not storage-stable due to polymerisation, and, if not concentrated, is of only limited efficacy.
The present invention provides a novel glutaraldehyde-containing composition useful for the removal of warts, which is at least as effective as the known aqueous glutaraldehyde solutions, and has important practical advantages in use.
The present invention provides a composition for removing warts, which comprises in a single phase from 1 to 25% by weight of glutaraldehyde, 50 to 98% by weight of one or more volatile organic solvents of from 1 to 4 carbon atoms capable of forming a hydrogen-bond with water and/or glutaraldehyde, and 1 to 45% by weight of water, the percentage by weight of glutaraldehyde being at least 1/9 of, but not more than equal to, the percentage by weight of water, the percentages being based on the combined weight of glutaraldehyde, solvent(s) and water and the .pH, of the ccnposition being from 3.5 to 7.0. Thus the ccnposition may caitain fran 1% to 25% by weight of water. - This composition is appliej to the warts until they disappear. As compared with the known compositions containing glutaraldehyde used for treatment of warts, these new ccnpositians have
- 3 a much greater volatility and are much easier to apply solely to the wart being' treated. Moreover, after application to the wart and evaporation of the volatile solvent, they provide on the wart a high effective concentration of glutaraldehyde, which can then act on the wart before having a chance to polymerise. There is no need for them to be buffered to an alkaline pH, and, as ordinarily used, they should have a pH in the range of 3.5 to 5,0 preferably from 4.2 to 4.4, at which pH they are fully effective because of the high effective concentration of the glutaraldehyde. Moreover, the new compositions penetrate well into the treated wart.
This composition is prepared by mixing together the constituents described above in any order, or simultaneously, in the proportions detailed above. Of course, previously prepared mixtures of two constituents, such as commercially available 25% by Weight or 50% by weight aqueous glutaraldehyde solution, may be used. It is not ordinarily desirable to add any other water to the composition, since the inclusion of too much water unnecessarily reduces the volatility of the composition, which is one of its practical advantages.
The organic solvent, or mixture of solvents, used must be capable of dissolving the glutaraldehyde and water present so as to form a composition forming a single phase.
- '4 44770
Examples of such solvents are acetone, and preferably an alkanol of 1 to 3 carbon atoms such as isopropanoi or, better, ethanol, which may be used in the form of industrial methylated spirit. Alkanols are further preferred since they inhibit the polymerisation of the glutaraldehye, it is believed by combining with the aldehyde groups in a reversible equilibrium involving formation of hemiacetals and acetals and release the free aldehyde on evaporation.
In order to improve its acceptability to the 10 user, the new compositions may contain, in addition to the compounds already mentioned, an appropriate colouring material and/or perfume. It may also, if desired, contain a thickener, such as methyl cellulose, pyroxylin, sodium carboxymethyl cellulose in order to make even easier the localisation of the treatment on the wart. It is, of course, essential that any such thickener, or other material added, be soluble in the solvent or solvents used.
A preferred composition comprises 40 parts by weight of 25% aqueous glutaraldehyde solution (providing
parts by weight of glutaraldehyde and 30 parts by weight water) and 60 parts by weight of industrial methylated spirit (typically 5 volumes methanol per 100 volumes 190° (U.S.) proof ethanol) at a pH of 4.2.
A second preferred composition consists of 5% by weight of glutaraldehyde, 5% by weight of water, and 90% by
- 5 Ο*7® weight of a composition known as collodion-acetone of 5g pyroxylin (a mixture of nitrated polysaccharides of high molecular weight (CgEggOgip,» consisting of at least 200 glycopyranose units such that there are 2 to 2¾ nitrate groups per sugar unit) in 2.5 ml castor oil and 10 ml ethoxyethanol, further made up to 100 ml with acetone at a pH of 4.3. These compositions may be coloured, perfumed and/or thickened as desired in the manner already indicated.
By applying the new cosmetic compositions on to a wart, it is possible to totally eradicate painful and disfiguring warts from the epidermis of someone suffering therefrom, and it has been found that the removal is often permanent with no re-growth of the treated warts. The application of the composition requires no skill and is easily carried out by the user in the peace and privacy of his or her own dwelling.
Claims (25)
1. CLAIMS:1. A composition for removing warts which comprises in a single phase from 1% to 25% by weight of glutaraldehyde, from 50% to 98% by weight of one or more volatile, organic 5 solvent(s) of from 1 to 4 carbon atoms capable of forming a hydrogen bond with water or glutaraldehyde, and from 1% to • 45% by weight of water, in which the percentage by weight of glutaraldehyde is at least 1/9 of, but not more than equal to, the percentage by weight of water, the percentages being ]_ 0 based on the combined weight of glutaraldehyde, solvent(s) and water, and the pH of the composition being from 3.5 to 7.0
2. A composition according to claim 1, in which the pH is from 3.5 to 5.0.
3. A composition according to claim 2, in which 15 the pH is from 4.2 to 4.4.
4. A composition according to any one of claims 1 to 3 in which the volatile organic solvent(s) is one or more of acetone, and an alkanol of 1 to 3 carbon atoms.
5. A composition according to claim 4, in which the 20 alkanol is isopropanol or ethanol.
6. A composition according to claim 5, in which the ethanol is in the form of industrial methylated spirit.
7. A composition according to any one of claims 1 to 6,.in which colouring material and/or perfume is additionally present.
8. A composition according to any one of claims 1 to 5 7 in Which a thickener is additionally present.
9. A composition according to claim 8, in which the thickener is methyl cellulose, pyroxylin or sodium carboxymethyl cellulose.
10. A composition according to claim 1, in which 1θ 40 parts by weight of 25% aqueous glutaraldehyde solution and 60 parts by weight of industrial methylated spirit are present at a pH of 4.2.
11. A composition according to claim 1 in which 5% by weight of glutaraldehyde, 5% by weight of water and 15 90% by weight of collodion-acetone are present at a pH of 4.3.
12. A process for the manufacture of a composition for removing warts which comprises mixing together as constituents glutaraldehyde, water and one or more volatile, 20 organic solvent(s) of from 1 to 4 carbon atoms capable of forming a hydrogen bond with water or glutaraldehyde in any order, or simultaneously, in the proportions of from - 8 44770 1% to 25% by weight of glutaraldehyde, 50% to 98% by weight of one or more volatile, organic solvent(s) and from 1% to 45% by weight of water, such that the resulting mixture has a pH of from 3.5 to 7.0, the percentages being based 5 on the combined weight of glutaraldehyde, solvent(s) and water, and the percentage by weight of glutaraldehyde being at least 1/9 of, but not more than equal to, the percentage by weight of water.
13. A process according to claim 12, in which 10 two of glutaraldehyde, water and the volatile organic solvent(s) have been previously mixed together before admixture with the remaining constituent.
14. A process according to claim 12 or 13, in which 25% or 50% by weight aqueous glutaraldehyde solution 15. Is used.
15. A process according to any one of claims 12 to 14 in which the volatile, organic solvent(s) is one or more of acetone, and an alkanol of 1 to 3 carbon atoms.
16. A process according to claim 15, in which 2o the alkanol is isopropanoi or ethanol.
17. A process according to claim 16, in which the ethanol is in the form of industrial methylated spirit.
18. A process according to any one of claims 12 to 17 in which colouring material and/or perfume is added to the mixture. I ’
19. A process according to any one of claims 12 to 18 in 5 which a thickener is added to the mixture. 1 I
20. A process, according to claim 19, in which the thickener is methyl cellulose, pyroxylin or sodium carboxymethyl cellulose.
21. A process according to any one of claims 12 to 19 in which 10 the resulting pH.is from 3.5 to 5.0.
22. A process according to claim 21, in which the pH is from 4.2 to 4.4.
23. A process as claimed in claim 12 substantially as hereinbefore described. 15
24. A cosmetic composition for ranoving warts whenever prepared by a process as claimed in any one of claims 12 to 23.
25. A composition according to claim 1, which comprises 1% to 25% by weight of glutaraldehyde, 50% to 98% by weight of an alkanol of from 1 to 3 carbon atoms and 1% to 25% by weight of 20 water.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4570/76A GB1522551A (en) | 1976-02-05 | 1976-02-05 | Compositions for topical application |
Publications (2)
Publication Number | Publication Date |
---|---|
IE44770L IE44770L (en) | 1977-08-05 |
IE44770B1 true IE44770B1 (en) | 1982-03-24 |
Family
ID=9779643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE241/77A IE44770B1 (en) | 1976-02-05 | 1977-02-04 | Improvements in and relating to compositions for topical application |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5296743A (en) |
AU (1) | AU509605B2 (en) |
BE (1) | BE851137A (en) |
CA (1) | CA1083965A (en) |
DE (1) | DE2704719A1 (en) |
DK (1) | DK48177A (en) |
FI (1) | FI770390A (en) |
FR (1) | FR2340088A1 (en) |
GB (1) | GB1522551A (en) |
IE (1) | IE44770B1 (en) |
NL (1) | NL7701194A (en) |
NO (1) | NO770376L (en) |
NZ (1) | NZ183254A (en) |
SE (1) | SE430019B (en) |
ZA (1) | ZA77645B (en) |
-
1976
- 1976-02-05 GB GB4570/76A patent/GB1522551A/en not_active Expired
-
1977
- 1977-02-04 NZ NZ183254A patent/NZ183254A/en unknown
- 1977-02-04 ZA ZA770645A patent/ZA77645B/en unknown
- 1977-02-04 FR FR7703230A patent/FR2340088A1/en active Granted
- 1977-02-04 NO NO770376A patent/NO770376L/en unknown
- 1977-02-04 BE BE174708A patent/BE851137A/en not_active IP Right Cessation
- 1977-02-04 NL NL7701194A patent/NL7701194A/en not_active Application Discontinuation
- 1977-02-04 IE IE241/77A patent/IE44770B1/en not_active IP Right Cessation
- 1977-02-04 CA CA271,366A patent/CA1083965A/en not_active Expired
- 1977-02-04 DK DK48177A patent/DK48177A/en not_active Application Discontinuation
- 1977-02-04 JP JP1086477A patent/JPS5296743A/en active Pending
- 1977-02-04 AU AU21967/77A patent/AU509605B2/en not_active Expired
- 1977-02-04 SE SE7701264A patent/SE430019B/en not_active IP Right Cessation
- 1977-02-04 FI FI770390A patent/FI770390A/fi not_active Application Discontinuation
- 1977-02-04 DE DE19772704719 patent/DE2704719A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
IE44770L (en) | 1977-08-05 |
CA1083965A (en) | 1980-08-19 |
ZA77645B (en) | 1977-12-28 |
JPS5296743A (en) | 1977-08-13 |
SE430019B (en) | 1983-10-17 |
NZ183254A (en) | 1984-03-30 |
AU2196777A (en) | 1978-08-10 |
FR2340088B1 (en) | 1982-06-18 |
BE851137A (en) | 1977-05-31 |
FR2340088A1 (en) | 1977-09-02 |
DK48177A (en) | 1977-08-06 |
FI770390A (en) | 1977-08-06 |
AU509605B2 (en) | 1980-05-15 |
DE2704719A1 (en) | 1977-08-11 |
NL7701194A (en) | 1977-08-09 |
SE7701264L (en) | 1977-08-06 |
NO770376L (en) | 1977-08-08 |
GB1522551A (en) | 1978-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |