KR102183186B1 - Cosmetic Composition Comprising High Concentration of Vitamin C - Google Patents

Abstract

The present invention relates to a hypoallergenic cosmetic composition which stably solubilizes a high concentration of vitamin C, has an excellent feeling of use without slipping and stickiness, and significantly reduces skin irritation even though the hypoallergenic cosmetic composition contains the high concentration of vitamin C. The present invention is to provide a cosmetic composition containing: 3 to 40 wt% of at least one selected from ascorbic acid and salts thereof; (b) glycol ethers; (c) a sterol compound; (d) basic amino acids; and (e) a glyceryl ascorbic acid.

Description

Cosmetic Composition Comprising High Concentration of Vitamin C}

The present invention relates to a high-concentration vitamin C cosmetic composition. More specifically, the present invention relates to a hypoallergenic cosmetic composition and a cosmetic comprising the same, even though it contains a high concentration of vitamin C, the skin irritation is significantly reduced compared to the existing product.

Vitamin C is a strong reducing agent 　 is one of the essential components in the human body, such as activating the synthase of collagen 　 scurvy occurs when the body lacks this vitamin. Vitamin C is a cofactor of at least eight enzymatic reactions that cause the most severe symptoms of scurvy when collagen synthesis fails, and these reactions are particularly important for wound healing and prevention of capillary bleeding. Vitamin C also acts as an antioxidant that protects against oxidizing substances.

When vitamin C is applied to the skin, it not only reduces melanin production to tone up and whitens, but also protects the skin by neutralizing harmful oxygen in the skin, which increases due to ultraviolet rays, and strengthens the skin barrier. It is known to promote the production of collagen and even anti-aging.

However, despite the beneficial effects of vitamin C, it is difficult to stably solubilize vitamin C, and even if emulsification is difficult, there is a problem in that the skin slip and stickiness problems occur. In addition, it is known that strong skin irritation occurs when vitamin C is applied to the skin at a high concentration.

Existing studies have mainly focused on stably solubilizing high-concentration vitamin C, or improving the feeling of use such as skin slippage and stickiness. For example, Japanese Patent Publication No.6352560 provides a cosmetic composition with excellent stability by blending polyethylene glycol, but does not provide a specific plan on how to reduce skin irritation caused by high concentration of vitamin C. .

Thus, there is an urgent need to develop a high-concentration vitamin C cosmetic composition that not only stably solubilizes vitamin C, which is an active ingredient, but also reduces skin irritation such as irritation and redness.

Throughout this specification, a number of documents are referenced and citations are indicated. The disclosure contents of the cited documents are incorporated by reference in this specification as a whole, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly described.

Japanese Patent Publication No. 6352560

Vitamin C is an aqueous alkali solution, and it dissolves well in water, but its stability is poor. In particular, in the acidic side, solubility is limited and it is necessary to use solvents in combination to increase the concentration, but in this case, there is a problem that skin irritation is caused by the use of solvents. As a result of research efforts to solve skin irritation problems such as feeling pain or redness when an aqueous solution of vitamin C is applied to the skin, the present inventors do not stop at stably solubilizing vitamin C and improving the feeling of use. The present invention was completed by developing a high-concentration vitamin C cosmetic composition with reduced irritation.

One aspect of the present invention is (a) 3% by weight or more to 40% by weight or less of at least one selected from ascorbic acid and salts thereof; (b) glycol ether; (c) sterol compounds; (d) basic amino acids; And (e) to provide a cosmetic composition containing glyceryl ascorbic acid.

Ascorbic acid, which is included as an active ingredient such as tone-up, whitening, and anti-aging in the cosmetic composition of the present invention, is also referred to as vitamin C, and usually refers to an L body. Ascorbic acid can be commercially purchased and used as a component of external preparations for skin in the fields of pharmaceuticals, quasi-drugs and cosmetics, and salts thereof can be used.

The salt of ascorbic acid is an inorganic salt (e.g., an alkali metal salt such as ammonium salt, sodium salt, potassium salt, alkaline earth metal salt such as calcium salt, magnesium salt, aluminum salt) or an organic salt (eg, salt of organic bases, amino acid salt, Amine salts) and the like, but are not limited thereto.

In the present invention, ascorbic acid or salts thereof may be used in combination of one or two or more, and the content thereof is 1% by weight or more, 5% by weight or more, 10% by weight or more, 15 It may be included in an amount of at least 20 wt%, at least 25 wt%, at least 30 wt%, or at least 40 wt%, and preferably in an amount of 3 to 40 wt%.

The glycol ether contained in the cosmetic composition of the present invention serves to dissolve and stabilize vitamin C. Glycol ethers include ethoxydiglycol, ethylene glycol mono methyl ether, ethylene glycol mono ethyl ether, ethylene glycol mono propyl ether, ethylene glycol mono butyl ether, ethylene glycol mono isobutyl ether, diethylene glycol methyl ether, diethylene glycol butyl ether, It can be selected from dipropylene glycol mono methyl ether, dipropylene glycol mono ethyl ether, dipropylene glycol mono propyl ether, and the like, preferably ethoxydiglycol.

The content of glycol ether contained in the cosmetic composition of the present invention is 1% by weight or more, 5% by weight or more, 10% by weight or more, 15% by weight or more, 20% by weight or more, 25% by weight or more, 30% by weight or more, or 40% by weight It may be included in% or more, and preferably in an amount of 3 to 40% by weight.

The sterol compound may be 1 or more selected from the group consisting of POE (polyoxyethylene) ether, PPG (polypropylene glycol) ether, and PEG (polyethylene glycol) ether of sterol, and the content thereof is 0.1% by weight or more, 0.2% by weight or more, 0.3 Wt% or more, 0.4 wt% or more, 0.5 wt% or more, 0.6 wt% or more, 0.7 wt% or more, 0.8 wt% or more, 0.9 wt% or more, 1 wt% or more, 2 wt% or more, 3 wt% or more, 4 It may be included in an amount of at least 5 wt%, preferably at least 0.5 to 3 wt%.

The present inventors believe that hypoallergenic can be achieved by mixing POE of sterol, PPG, or PEG ether in an aqueous solution of ascorbic acid and basic amino acid salt of ascorbic acid and glyceryl ether of ascorbic acid. It has been found that it is possible to obtain a high-concentration vitamin C-containing serum that has excellent texture and is mild.

Conventional POE additive surfactants such as Pluronic and HCO surfactants are known to be indispensable for dissolving fragrances, but many POE additive surfactants have a disadvantage in that they have great skin irritation. In the case of using such an existing POE additive surfactant, a product having a high concentration can be made, but it is difficult to make a high concentration of a vitamin C product. In addition, a sticky feel of the aqueous surfactant solution occurs.

In the case of using the sterol derivative compound of the present invention instead of the conventional POE additive surfactant, the refractive index is high, so that it is shiny, it is easy to form a liquid crystal, and a liquid crystal is formed from a low concentration, and micelles and liquid crystals are firm and sticky. It has the advantage of not feeling. In particular, when the sterol derivative compound of the present invention is used, there is an advantage of obtaining superior hypoallergenicity than other conventional POE adducts and POE addition surfactants. In a preferred embodiment, polyoxyethylene phytosterol may be used as the POE sterol.

The basic amino acid contained in the cosmetic composition of the present invention may be one or more selected from the group consisting of arginine, lysine and histidine, and the effect of hypoallergenic high concentration vitamin C by mixing a small amount of these basic amino acids is unknown.

In a preferred embodiment, the cosmetic composition of the present invention further comprises glyceryl ascorbic acid.

In addition, the cosmetic composition of the present invention may further include a gentiana extract, which may be a gentiana root extract (Gentiana Lutea Root Extract). The present inventors have found that this ingredient not only reduces irritation in high-content vitamin C formulations, but also has a synergistic effect in relation to reducing irritation caused by high-content vitamin C, especially when used in combination with other ingredients. Revealed.

As described above, the cosmetic composition of the present invention stabilizes ascorbic acid by using glycol ether and glyceryl ascorbic acid as solvents, and also has a feature of achieving hypoallergenic vitamin C through gentiana extract.

In addition, the cosmetic composition of the present invention may further include vitamin C glucoside. Vitamin C glucoside refers to a substance that stabilizes vitamin C by attaching a molecule of glucose (glucose) to the 2nd hydroxyl group of vitamin C. Vitamin C glucoside is easily soluble in water, but its hypoallergenic properties of ascorbic acid have not been known. In the present invention, it was found that vitamin C glucoside is not only involved in stable solubilization, but plays a role in reducing skin irritation.

The cosmetic composition according to the present invention may be prepared in various formulations such as solution, nutrient lotion, softening lotion, softening water, emulsion, essence, suspension, emulsion, gel, lotion, etc., but is not limited thereto.

The present invention provides a hypoallergenic cosmetic composition that stably solubilizes a high concentration of vitamin C, has an excellent feeling of use without slipping and stickiness, and significantly reduces skin irritation even though it contains a high concentration of vitamin C.

Hereinafter, the present invention will be described in more detail through examples. These examples are for illustrative purposes only, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples.

Example

I. High vitamin C concentration Cosmetic Preparation of the composition

An emulsifying formulation in the form of water-in-oil dispersion was prepared by using the compositions of Table 1 below (unit is weight %).

Example
One Example
2 Example
3 Example
4 Example
5 Comparative example
One Comparative example
2 Comparative Example 3 Ascorbic acid 20 20 20 20 25 20 20 25 Ethoxydiclichol
(Transcutol®) 20 25 30 20 40 20 30 40 PEG/PPG-300/55 COPOLYMER 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 glycerin 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Tocopherol 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Caster oil 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 PEG-30 Phytosterol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 PEG-20 PHYTOSTEROL 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Polysorbate 80 - - - - - - 1.0 Triethanolamine - - - - - 1.3 - Lysine 0.1 0.1 0.1 0.1 0.1 - 0.1 0.1 Ferulic acid 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Betaine 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 3-glyceryl ascorbic acid 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Ethyl ascorbic acid 1.5 Gentiana extract 0.02 0.02 0.02 0.02 Hyaluronic acid 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

The sterol compounds used (PEG-30 phytosterol and PPG-5 phytosterol) were purchased and used from Nikko Chemicals Co., Ltd., Japan.

II. Skin irritation evaluation

Fifty female professional panels in their 20s and 40s were selected, and the cosmetic compositions of Examples and Comparative Examples were used on the face after washing face every evening for 7 days. After 7 days, the degree of skin irritation was evaluated according to the following evaluation items and evaluation criteria, and the results are shown in Table 2.

[Skin irritation evaluation items]

The degree of pain (including soreness), redness, and dryness of the skin

[Evaluation standard]

Very low skin irritation: 5 points

Low skin irritation: 4 points

Normal skin irritation: 3 points

High skin irritation: 2 points

Very high skin irritation: 1 point

Example 1 Example 2 Example 3 Example
4 Example 5 Comparative Example 1 Comparative Example 2 Comparative example
3 Skin irritation score 4.2 4.2 4.3 3.9 4.1 2.5 2.4 2.2

As a result of the experiment, in the case of containing the gentiana extract, it was possible to obtain a mild result regardless of the content of ethoxy diclichol. In particular, it was confirmed that the use of Gentiana extract has a synergistic effect in relation to the reduction of skin irritation caused by high concentration of vitamin C.

On the other hand, Comparative Example 1 containing triethanolamine, Comparative Example 2 using ethyl ascorbic acid instead of glyceryl ascorbic acid, and Comparative Example 3 containing a nonionic surfactant (polysorbate 80) instead of a sterol compound In the case of, it was found that skin irritation was severe due to high concentration of vitamin C.

All of the formulations shown in Table 1 were able to obtain a stabilization result of ascorbic acid.

Claims (5)

(a) 3% by weight or more to 40% by weight or less of at least one selected from ascorbic acid and salts thereof;
(b) glycol ether;
(c) sterol compounds;
(d) basic amino acids; And
(e) glyceryl ascorbic acid
High-concentration vitamin C cosmetic composition comprising a. The high-concentration vitamin C cosmetic composition of claim 1, wherein the composition further comprises Gentiana Extract. The high-concentration vitamin C cosmetic composition of claim 1, wherein the composition further comprises vitamin C glucoside. The high-concentration vitamin C of claim 1, wherein the sterol compound is at least one selected from the group consisting of POE (polyoxyethylene) ether of sterol, polypropylene glycol (PPG) ether of sterol, and PEG (polyethylene glycol) ether of sterol. Cosmetic composition. The high-concentration vitamin C cosmetic composition of claim 1, wherein the basic amino acid is at least one selected from the group consisting of arginine, lysine, and histidine.