IE44541B1 - Modified protein reproductive hormone antigens - Google Patents
Modified protein reproductive hormone antigensInfo
- Publication number
- IE44541B1 IE44541B1 IE2248/76A IE224876A IE44541B1 IE 44541 B1 IE44541 B1 IE 44541B1 IE 2248/76 A IE2248/76 A IE 2248/76A IE 224876 A IE224876 A IE 224876A IE 44541 B1 IE44541 B1 IE 44541B1
- Authority
- IE
- Ireland
- Prior art keywords
- pro
- polypeptide
- ser
- antigen
- process according
- Prior art date
Links
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- 238000010168 coupling process Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 1
- 229960004198 guanidine Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 108010053037 kyotorphin Proteins 0.000 description 1
- 108010073472 leucyl-prolyl-proline Proteins 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- IFPHDUVGLXEIOQ-UHFFFAOYSA-N ortho-iodosylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1I=O IFPHDUVGLXEIOQ-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000005628 tolylene group Chemical group 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62203175A | 1975-10-14 | 1975-10-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44541L IE44541L (en) | 1977-04-14 |
| IE44541B1 true IE44541B1 (en) | 1981-12-30 |
Family
ID=24492662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2248/76A IE44541B1 (en) | 1975-10-14 | 1976-10-12 | Modified protein reproductive hormone antigens |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5251017A (nl) |
| AU (1) | AU513558B2 (nl) |
| BE (1) | BE847243R (nl) |
| DE (1) | DE2646223A1 (nl) |
| FR (1) | FR2327797A2 (nl) |
| GB (1) | GB1567764A (nl) |
| HK (1) | HK10883A (nl) |
| IE (1) | IE44541B1 (nl) |
| MY (1) | MY8500808A (nl) |
| NL (1) | NL7611212A (nl) |
| NZ (1) | NZ182272A (nl) |
| SG (1) | SG63582G (nl) |
| ZA (1) | ZA766143B (nl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526716A (en) * | 1981-11-20 | 1985-07-02 | The Ohio State University | Antigenic modification of polypeptides |
| US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| EP0326111A3 (en) * | 1988-01-29 | 1989-12-27 | New York Blood Center, Inc. | Peptide derivatives rendered immunogenic when administered with alum as an adjuvant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1467782A1 (de) * | 1963-07-17 | 1968-12-12 | Behringwerke Ag | Verfahren zur Herstellung von kuenstlichen Antigenen |
| CH622426A5 (en) * | 1973-05-07 | 1981-04-15 | Univ Ohio | Contraceptive composition |
-
1976
- 1976-10-08 NZ NZ182272A patent/NZ182272A/en unknown
- 1976-10-11 NL NL7611212A patent/NL7611212A/nl not_active Application Discontinuation
- 1976-10-12 GB GB42319/76A patent/GB1567764A/en not_active Expired
- 1976-10-12 IE IE2248/76A patent/IE44541B1/en unknown
- 1976-10-13 BE BE171483A patent/BE847243R/xx not_active IP Right Cessation
- 1976-10-13 DE DE19762646223 patent/DE2646223A1/de active Granted
- 1976-10-13 FR FR7630804A patent/FR2327797A2/fr active Granted
- 1976-10-14 JP JP51123370A patent/JPS5251017A/ja active Pending
- 1976-10-14 ZA ZA00766143A patent/ZA766143B/xx unknown
-
1978
- 1978-10-12 AU AU18584/76A patent/AU513558B2/en not_active Expired
-
1982
- 1982-12-23 SG SG63582A patent/SG63582G/en unknown
-
1983
- 1983-03-24 HK HK108/83A patent/HK10883A/xx unknown
-
1985
- 1985-12-30 MY MY808/85A patent/MY8500808A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1858476A (en) | 1978-04-20 |
| IE44541L (en) | 1977-04-14 |
| DE2646223A1 (de) | 1977-04-28 |
| SG63582G (en) | 1983-09-09 |
| AU513558B2 (en) | 1980-12-11 |
| NL7611212A (nl) | 1977-04-18 |
| ZA766143B (en) | 1978-05-30 |
| GB1567764A (en) | 1980-05-21 |
| DE2646223C2 (nl) | 1990-09-27 |
| MY8500808A (en) | 1985-12-31 |
| FR2327797A2 (fr) | 1977-05-13 |
| BE847243R (fr) | 1977-04-13 |
| JPS5251017A (en) | 1977-04-23 |
| HK10883A (en) | 1983-03-24 |
| NZ182272A (en) | 1985-03-20 |
| FR2327797B2 (nl) | 1979-03-02 |
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